Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders.

Autor: Kannt A; Fraunhofer Institute for Translational Medicine and Pharmacology-ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany., Rajagopal S; Jubilant Biosys Limited, #96, Industrial Suburb, 2nd Stage Yeshwanthpur, Bangalore 560022, India., Hallur MS; Jubilant Biosys Limited, #96, Industrial Suburb, 2nd Stage Yeshwanthpur, Bangalore 560022, India., Swamy I; Jubilant Biosys Limited, #96, Industrial Suburb, 2nd Stage Yeshwanthpur, Bangalore 560022, India., Kristam R; Jubilant Biosys Limited, #96, Industrial Suburb, 2nd Stage Yeshwanthpur, Bangalore 560022, India., Dhakshinamoorthy S; Jubilant Biosys Limited, #96, Industrial Suburb, 2nd Stage Yeshwanthpur, Bangalore 560022, India., Czech J; Sanofi-Aventis Deutschland Gmbh, Industriepark Hoechst, 65926 Frankfurt am Main, Germany., Zech G; Sanofi-Aventis Deutschland Gmbh, Industriepark Hoechst, 65926 Frankfurt am Main, Germany., Schreuder H; Sanofi-Aventis Deutschland Gmbh, Industriepark Hoechst, 65926 Frankfurt am Main, Germany., Ruf S; Sanofi-Aventis Deutschland Gmbh, Industriepark Hoechst, 65926 Frankfurt am Main, Germany.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2021 Feb 13; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 13.

Discovery and optimization of novel phenyldiazepine and pyridodiazepine based Aurora kinase inhibitors.

Autor: Tamizharasan N; Supramolecular and Catalysis Lab, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India; Medicinal Chemistry Department, Jubilant Biosys Ltd., Bangalore 560022, Karnataka, India., Gajendran C; Oncology Department, Jubilant Biosys Ltd., Bangalore 560022, Karnataka, India., Kristam R; Computational Chemistry Department, Jubilant Biosys Ltd., Bangalore 560022, Karnataka, India., Sulochana SP; Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd., Bangalore 560022, Karnataka, India., Sivanandhan D; Oncology Department, Jubilant Biosys Ltd., Bangalore 560022, Karnataka, India., Mullangi R; Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd., Bangalore 560022, Karnataka, India., Mathivathanan L; Florida International University, 11200, SW 8(th) St, Miami, FL 33199, USA., Hallur G; Medicinal Chemistry Department, Jubilant Biosys Ltd., Bangalore 560022, Karnataka, India. Electronic address: Gurulinappa.hallur@jubilantbiosys.com., Suresh P; Supramolecular and Catalysis Lab, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India. Electronic address: suresh.chem@mkuniversity.ac.in.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2020 Jun; Vol. 99, pp. 103800. Date of Electronic Publication: 2020 Mar 29.

Exploring NNMT: from metabolic pathways to therapeutic targets.

Autor: Park J; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea.; Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, 61452, Republic of Korea.; Institute of Well-Aging Medicare & Chosun University G-LAMP Project Group, Chosun University, Gwangju, 61452, Republic of Korea., Shin EJ; Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, 61452, Republic of Korea.; Institute of Well-Aging Medicare & Chosun University G-LAMP Project Group, Chosun University, Gwangju, 61452, Republic of Korea.; Department of Integrative Biological Sciences & BK21 FOUR Educational Research Group for Age-Associated Disorder Control Technology, Chosun University, Gwangju, 61452, Republic of Korea., Kim TH; Drug Information Research Institute, Muscle Physiome Research Center, College of Pharmacy, Sookmyung Women's University, Seoul, 04310, South Korea., Yang JH; College of Korean Medicine, Dongshin University, Naju, Jeollanam-Do, 58245, Republic of Korea., Ki SH; College of Pharmacy, Chosun University, Gwangju, 61452, Republic of Korea., Kang KW; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea., Kim KM; Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, 61452, Republic of Korea. kmkim@chosun.ac.kr.; Institute of Well-Aging Medicare & Chosun University G-LAMP Project Group, Chosun University, Gwangju, 61452, Republic of Korea. kmkim@chosun.ac.kr.; Department of Integrative Biological Sciences & BK21 FOUR Educational Research Group for Age-Associated Disorder Control Technology, Chosun University, Gwangju, 61452, Republic of Korea. kmkim@chosun.ac.kr.

Publikováno v: Archives of pharmacal research [Arch Pharm Res] 2024 Dec; Vol. 47 (12), pp. 893-913. Date of Electronic Publication: 2024 Nov 28.

Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.

Autor: Ruf S; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany. Electronic address: Sven.Ruf@sanofi.com., Hallur MS; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Anchan NK; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Swamy IN; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Murugesan KR; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Sarkar S; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Narasimhulu LK; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Putta VPRK; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Shaik S; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Chandrasekar DV; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Mane VS; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Kadnur SV; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Suresh J; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Bhamidipati RK; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Singh M; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Burri RR; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Kristam R; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Schreuder H; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Czech J; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Rudolph C; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Marker A; R&D Drug Metabolism & Pharmacokinetics, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Langer T; Biologics Research, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Mullangi R; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Yura T; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Gosu R; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Kannt A; R&D Diabetes, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany; Institute of Experimental Pharmacology, Medical Faculty Mannheim, University of Heidelberg, D-68167 Mannheim, Germany., Dhakshinamoorthy S; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Rajagopal S; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India. Electronic address: sridharan_rajagopal@jubilantbiosys.com.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Mar 01; Vol. 28 (5), pp. 922-925. Date of Electronic Publication: 2018 Jan 31.

Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.

Autor: Swaminathan S; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Birudukota S; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Thakur MK; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Parveen R; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Kandan S; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Juluri S; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Shaik S; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Anand NN; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Burri RR; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Kristam R; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Hallur MS; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Rajagopal S; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Schreuder H; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany., Langer T; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany., Rudolph C; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany., Ruf S; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany., Dhakshinamoorthy S; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Gosu R; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India. Electronic address: ramachandraiah_gosu@jubilantbiosys.com., Kannt A; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany; Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2017 Sep 16; Vol. 491 (2), pp. 416-422. Date of Electronic Publication: 2017 Jul 15.