Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Krista Rantanen"'
Autor:
Petra Miikkulainen, Heidi Högel, Krista Rantanen, Tomi Suomi, Petri Kouvonen, Laura L. Elo, Panu M. Jaakkola
Publikováno v:
Cancer & Metabolism, Vol 5, Iss 1, Pp 1-17 (2017)
Abstract Background A key feature of clear cell renal cell carcinoma (ccRCC) is the inactivation of the von Hippel-Lindau tumour suppressor protein (pVHL) that leads to the activation of hypoxia-inducible factor (HIF) pathway also in well-oxygenated
Externí odkaz:
https://doaj.org/article/653e76bfcb16431caf12436de93d5e7a
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27112 (2011)
Hypoxia restricts cell proliferation and cell cycle progression at the G1/S interface but at least a subpopulation of carcinoma cells can escape the restriction. In carcinoma hypoxia may in fact select for cells with enhanced hypoxic survival and inc
Externí odkaz:
https://doaj.org/article/35ce1d1d8ee24c4c93893ba18fcc6995
Autor:
Heidi Högel, Krista Rantanen, Panu Jaakkola, Fatemeh Seyednasrollah, Petra Miikkulainen, Laura L. Elo
Publikováno v:
Journal of Biological Chemistry. 294:3760-3771
Most clear cell renal cell carcinomas (ccRCCs) have inactivation of the von Hippel-Lindau tumor suppressor protein (pVHL), resulting in the accumulation of hypoxia-inducible factor -subunits (HIF-) and their downstream targets. HIF-2 expression is pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e3a799379906bd67a1430038f03a87
https://doi.org/10.1074/jbc.ra118.004902
https://doi.org/10.1074/jbc.ra118.004902
Autor:
Krista Rantanen, Petri Kouvonen, Heidi Högel, Petra Miikkulainen, Panu Jaakkola, Tomi Suomi, Laura L. Elo
Publikováno v:
Cancer & Metabolism, Vol 5, Iss 1, Pp 1-17 (2017)
Cancer & Metabolism
Cancer & Metabolism
Background A key feature of clear cell renal cell carcinoma (ccRCC) is the inactivation of the von Hippel-Lindau tumour suppressor protein (pVHL) that leads to the activation of hypoxia-inducible factor (HIF) pathway also in well-oxygenated condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce68250e80c1264ea49aeb476df298a8
https://doi.org/10.1186/s40170-017-0167-y
https://doi.org/10.1186/s40170-017-0167-y
Autor:
Juha-Pekka Pursiheimo, Jari Sundström, Krista Rantanen, Heidi Högel, Petra Miikkulainen, Panu Jaakkola
Publikováno v:
Journal of Cell Science. 126(5):1144-1154
Summary The hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 regulates cellular responses to hypoxia. In normoxia the expression of PHD3 is low and it occurs in cytosolic aggregates. SQSTM1/p62 (p62) recruits proteins into cytosolic aggregates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b40a66f48259a9e838f087962b125e
https://doi.org/10.1242/jcs.115667
https://doi.org/10.1242/jcs.115667
Publikováno v:
Nucleic Acids Research
Recent comprehensive assessments of RNA-seq technology support its utility in quantifying gene expression in various samples. The next step of rigorously quantifying differences between sample groups, however, still lacks well-defined best practices.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dba322870ae76267057bd1678c1a566
https://doi.org/10.1093/nar/gkv806
https://doi.org/10.1093/nar/gkv806
Autor:
Jari Sundström, Pekka T. Heikkinen, Krista Rantanen, Heidi Högel, Panu Jaakkola, Klaus Elenius, Terhi Jokilehto
Publikováno v:
Experimental Cell Research. 316:1169-1178
Cellular oxygen tension is sensed by a family of prolyl hydroxylases (PHD1-3) that regulate the degradation of hypoxia-inducible factors (HIF-1alpha and -2alpha). The PHD2 isoform is considered as the main downregulator of HIF in normoxia. Our previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ff11fc4b8ce795f7a6a4bff4158717
https://doi.org/10.1016/j.yexcr.2010.02.012
https://doi.org/10.1016/j.yexcr.2010.02.012
Publikováno v:
Oncogene. 28:334-344
Sequestosome 1 (SQSTM1/p62) is a multifunctional protein involved in signal transduction, protein degradation and cell transformation. Hypoxia is a common feature of solid tumours that promotes cancer progression. Here, we report that p62 is downregu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f726f5dc27462b7adbf8edf6b029686
https://doi.org/10.1038/onc.2008.392
https://doi.org/10.1038/onc.2008.392
Autor:
Pekka T. Heikkinen, Panu Jaakkola, Terhi Jokilehto, Reidar Grénman, Pauliina Kronqvist, Heikki Minn, Marjaana Luukkaa, Krista Rantanen
Publikováno v:
Clinical Cancer Research. 12:1080-1087
PURPOSE: Hypoxia in tumors is associated with poor prognosis and resistance to treatment. The outcome of hypoxia is largely regulated by the hypoxia-inducible factors (HIF-1alpha and HIF-2alpha). HIFs in turn are negatively regulated by a family of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275946743ca65fce9bb3dc6d2e84aa10
https://doi.org/10.1158/1078-0432.ccr-05-2022
https://doi.org/10.1158/1078-0432.ccr-05-2022
Autor:
Panu Jaakkola, Krista Rantanen
Publikováno v:
Biological chemistry. 394(4)
The prolyl 4-hydroxylase domain protein 3 (PHD3) belongs to 2-oxoglutarate and iron-dependent dioxygenases. Together with the two closest paralogues, PHD1 and PHD2, these enzymes have been identified as cellular oxygen sensors that can mark the hypox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f984b2abb3b3269f399dc3f53b7f653f
https://pubmed.ncbi.nlm.nih.gov/23380539
https://pubmed.ncbi.nlm.nih.gov/23380539