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pro vyhledávání: '"Krista M. Schroeder"'
Autor:
Krista M. Schroeder, Thomas P. Beyer, Ryan J. Hansen, Bomie Han, Richard T. Pickard, Victor J. Wroblewski, Mark C. Kowala, Patrick I. Eacho
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 11, Pp 2124-2132 (2015)
Lilly PCSK9 antibody LY3015014 (LY) is a monoclonal antibody (mAb) that neutralizes proprotein convertase subtilisin-kexin type 9 (PCSK9). LY decreases LDL cholesterol in monkeys and, unlike other PCSK9 mAbs, does not cause an accumulation of intact
Externí odkaz:
https://doaj.org/article/f9915123339b461b9a86c49a1bb6065e
Autor:
Bomie Han, Patrick I. Eacho, Michael D. Knierman, Jason S. Troutt, Robert J. Konrad, Xiaohong Yu, Krista M. Schroeder
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 7, Pp 1505-1514 (2014)
Proprotein convertase subtilisin-kexin type 9 (PCSK9) is a secreted protein which regulates serum LDL cholesterol. It circulates in human and rodent serum in an intact form and a major truncated form. Previous in vitro studies involving the expressio
Externí odkaz:
https://doaj.org/article/c418d74c90224ffda7dbe266040357e4
Autor:
Thomas P Beyer, Patrick I Eacho, Krista M Schroeder, Ryan J Hansen, Victor J Wroblewski, Bomie Han, Richard T Pickard, Mark C Kowala
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35
Introduction: Monoclonal antibodies (Mabs) that neutralize proprotein convertase subtilisin-kexin type 9 (PCSK9) have been shown to lower LDL-C in human trials. It is known that PCSK9 is cleaved by furin at Arg218 and that the cleaved PCSK9 is inacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2424fb404b29a0fb4d02ffe4974e6794
https://doi.org/10.1161/atvb.35.suppl_1.538
https://doi.org/10.1161/atvb.35.suppl_1.538