Výsledky vyhledávání - "Krista L. Penta"

Drug-Induced Activation of Dopamine D1 Receptor Signaling and Inhibition of Class I/II Histone Deacetylase Induce Chromatin Remodeling in Reward Circuitry and Modulate Cocaine-Related Behaviors

Autor: Frederick Albert Schroeder, Sara R. Jones, Krista L. Penta, Christine Konradi, Andrew R. Tapper, Schahram Akbarian, Anouch Matevossian

Publikováno v: Neuropsychopharmacology. 33:2981-2992

Chromatin remodeling, including histone modification, is involved in stimulant-induced gene expression and addiction behavior. To further explore the role of dopamine D(1) receptor signaling, we measured cocaine-related locomotor activity and place p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d8a7669a1b9dc8edc799bcf011f6f1
https://doi.org/10.1038/npp.2008.15

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Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis

Autor: Krista L. Penta, Punita Shroff, Andrew R. Tapper, David S. Garlick, Hayla Karen Sluss, Heather L. Armata

Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 9, p e24813 (2011)

Phosphorylation at murine Serine 18 (human Serine 15) is a critical regulatory process for the tumor suppressor function of p53. p53Ser18 residue is a substrate for ataxia-telangiectasia mutated (ATM) and ATM-related (ATR) protein kinases. Studies of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d40a5f9af6b3cbaf6d77935ba69be3
https://pubmed.ncbi.nlm.nih.gov/21980358

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Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol

Autor: Andrew R. Tapper, Linzy M. Hendrickson, Gilles E. Martin, Ryan M. Friesen, Krista L. Penta, Steven N. Treistman, Andrzej Z. Pietrzykowski

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 105(45)

Tolerance, described as the loss of drug effectiveness over time, is an important component of addiction. The degree of acute behavioral tolerance to alcohol exhibited by a naïve subject can predict the likelihood of alcohol abuse. Thus, the determi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f0ba498d23179ae48c99f63fff92d4
https://pubmed.ncbi.nlm.nih.gov/18981408

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