Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Krista L. Filomeno"'
Autor:
Ian M.C. Dixon, Thomas W. Meier, Robert R. Fandrich, Krista L. Filomeno, Todd A. Duhamel, Sunil G. Rattan, Elissavet Kardami, Navid Koleini, Sarah J. Foran, Simon C. Meier, Claire F. Meier, Natalie M. Landry
Publikováno v:
Basic Research in Cardiology
We have previously shown that overexpression of SKI, an endogenous TGF-β1 repressor, deactivates the pro-fibrotic myofibroblast phenotype in the heart. We now show that SKI also functions independently of SMAD/TGF-β signaling, by activating the Hip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8056941623b3cd6db791b339e12f41a2
https://doi.org/10.1007/s00395-021-00865-9
https://doi.org/10.1007/s00395-021-00865-9
Autor:
Ian M.C. Dixon, Besher Abual'anaz, Sunil G. Rattan, Krista L. Filomeno, Rebeca de Oliveira Camargo
Publikováno v:
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyREFERENCES. 29(4)
Heart disease with attendant cardiac fibrosis kills more patients in developed countries than any other disease, including cancer. We highlight the recent literature on factors that activate and also deactivate cardiac fibroblasts. Activation of card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5b96c10a90b3b18df263986e081c30
https://pubmed.ncbi.nlm.nih.gov/34076932
https://pubmed.ncbi.nlm.nih.gov/34076932
Autor:
Natalie M. Landry, Michael P. Czubryt, Morvarid S. Kavosh, Krista L. Filomeno, Sunil G. Rattan, Ian M.C. Dixon
Publikováno v:
Physiological Reports
Many etiologies of heart disease are characterized by expansion and remodeling of the cardiac extracellular matrix (ECM or matrix) which results in cardiac fibrosis. Cardiac fibrosis is mediated in cardiac fibroblasts by TGF‐β 1/R‐Smad2/3 signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ca6dee5b388050fddcd5062c6499a5
https://doi.org/10.14814/phy2.13897
https://doi.org/10.14814/phy2.13897
Autor:
Krista L Filomeno, Sunil G Rattan, Sheri Bage, Matthew Zeglinski, Michael P Czubryt, Ian M Dixon
Publikováno v:
Circulation Research. 117
Introduction: Coronary heart disease is causal to myocardial infarction (MI) and cardiac fibrosis. Upon ischemic myocardial injury, resident cardiac fibroblasts phenoconvert to myofibroblasts and synthesize large amounts of fibrillar collagens to pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf16775fcf308aee41b7f41e8b2a2e1b
https://doi.org/10.1161/res.117.suppl_1.372
https://doi.org/10.1161/res.117.suppl_1.372
Publikováno v:
Comprehensive Physiology
Long regarded as a mere accessory cell for the cardiomyocyte, the cardiac fibroblast is now recognized as a critical determinant of cardiac function in health and disease. A recent renaissance in fibroblast-centered research has fostered a better und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed781fa07cb0e5466d0438f6853f6cd
https://pubmed.ncbi.nlm.nih.gov/25880511
https://pubmed.ncbi.nlm.nih.gov/25880511
Autor:
Sunil G. Rattan, Fahmida Jahan, David Cheung, Ryan H. Cunnington, Jeffrey T. Wigle, Ian M.C. Dixon, Krista L. Filomeno, Josette M. Northcott
Publikováno v:
The FASEB Journal. 28
The fibroblast to myofibroblast phenoconversion, which is induced by TGF-β, is a crucial step during cardiac fibrosis. Activated myofibroblasts increase extracellular matrix (ECM) synthesis, which ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aff89d34e462c99d706650ade099fd1
https://doi.org/10.1096/fasebj.28.1_supplement.lb47
https://doi.org/10.1096/fasebj.28.1_supplement.lb47
Autor:
Saeid Ghavami, Jared J.L. Davies, Krista L. Filomeno, Jeffrey T. Wigle, Ryan H. Cunnington, Ian M.C. Dixon, Josette M. Northcott, Fahmida Jahan, Morvarid S. Kavosh
Publikováno v:
Journal of cell science. 127(Pt 1)
Cardiac fibrosis is linked to fibroblast-to-myofibroblast phenoconversion and proliferation but the mechanisms underlying this are poorly understood. Ski is a negative regulator of TGF-β-Smad signaling in myofibroblasts, and might redirect the myofi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07771b41e993cbcbcafca7237720ab9
https://pubmed.ncbi.nlm.nih.gov/24155330
https://pubmed.ncbi.nlm.nih.gov/24155330