Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Krista L. Dong"'
Autor:
Karine Dubé, Elizabeth Barr, Morgan Philbin, Amaya Perez-Brumer, Brian Minalga, Beth Peterson, Dawn Averitt, Bridgette Picou, Krista Martel, Cecilia Chung, María Mejía, Martha Cameron, Gail Graham, Lynda Dee, Dázon Dixon Diallo, Ebony Gordon, Anastasia Korolkova, Typhanye Dyer, Judith D. Auerbach, Eileen Scully, Krista L. Dong, Sara Gianella
Publikováno v:
HIV Research & Clinical Practice, Vol 24, Iss 1 (2023)
Background Cisgender women represent over half of people living with HIV globally. However, current research efforts toward a cure for HIV focus predominantly on cisgender men. The under-representation of women in HIV cure clinical studies is particu
Externí odkaz:
https://doaj.org/article/a0cfa59541f24e93ba154e91b78eb66a
Autor:
Paradise Madlala, Zakithi Mkhize, Shamara Naicker, Samukelisiwe P Khathi, Shreyal Maikoo, Kasmira Gopee, Krista L Dong, Thumbi Ndung'u
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011194 (2023)
A genetic bottleneck is a hallmark of HIV-1 transmission such that only very few viral strains, termed transmitted/founder (T/F) variants establish infection in a newly infected host. Phenotypic characteristics of these variants may determine the sub
Externí odkaz:
https://doaj.org/article/5ab1e66ddffb4a51b87f7c6e71106e4c
Autor:
Omolara O. Baiyegunhi, Jaclyn Mann, Trevor Khaba, Thandeka Nkosi, Anele Mbatha, Funsho Ogunshola, Caroline Chasara, Nasreen Ismail, Thandekile Ngubane, Ismail Jajbhay, Johan Pansegrouw, Krista L. Dong, Bruce D. Walker, Thumbi Ndung’u, Zaza M. Ndhlovu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Despite antiretroviral therapy, HIV often persists in tissue sanctuary sites. In this work, authors investigate HIV persistence and T cell responses in lymph node biopsies obtained from individuals who initiated antiretroviral therapy in Fiebig stage
Externí odkaz:
https://doaj.org/article/50e73a5e9c94475094bccd50e686c5cb
Autor:
Alexander Munoz, Matthew R. Hayward, Seth M. Bloom, Muntsa Rocafort, Sinaye Ngcapu, Nomfuneko A. Mafunda, Jiawu Xu, Nondumiso Xulu, Mary Dong, Krista L. Dong, Nasreen Ismail, Thumbi Ndung’u, Musie S. Ghebermichael, Douglas S. Kwon
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-12 (2021)
Abstract Background Cervicovaginal bacterial communities composed of diverse anaerobes with low Lactobacillus abundance are associated with poor reproductive outcomes such as preterm birth, infertility, cervicitis, and risk of sexually transmitted in
Externí odkaz:
https://doaj.org/article/340cfb0828a54631a00c8471991e17eb
Autor:
Doty Ojwach, Kamini Gounder, Takalani Mulaudzi, Nombali Gumede, Omolara O. Baiyegunhi, Kavidha Reddy, Jennifer Giandhari, Krista L. Dong, Zaza Ndhlovu, Thumbi Ndung’u, Jaclyn K. Mann
Publikováno v:
Frontiers in Virology, Vol 2 (2022)
HIV variants present in the reservoir, particularly in tissues, may differ from those present in peripheral blood prior to therapy initiation, and characterisation of these reservoir variants could better inform immune-based interventions for HIV cur
Externí odkaz:
https://doaj.org/article/7d91a2ac316445c1ac318bbcad3d8240
Autor:
Daniel M. Muema, Ngomu A. Akilimali, Okechukwu C. Ndumnego, Sipho S. Rasehlo, Raveshni Durgiah, Doty B.A. Ojwach, Nasreen Ismail, Mary Dong, Amber Moodley, Krista L. Dong, Zaza M. Ndhlovu, Jenniffer M. Mabuka, Bruce D. Walker, Jaclyn K. Mann, Thumbi Ndung’u
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Introduction Immunological damage in acute HIV infection (AHI) may predispose to detrimental clinical sequela. However, studies on the earliest HIV-induced immunological changes are limited, particularly in sub-Saharan Africa. We assessed th
Externí odkaz:
https://doaj.org/article/12144ae325134e809d1d43e98283a822
Autor:
Elizabeth H. Byrne, Mara Farcasanu, Seth M. Bloom, Nondumiso Xulu, Jiawu Xu, Barry L. Hykes, Nomfuneko A. Mafunda, Matthew R. Hayward, Mary Dong, Krista L. Dong, Thandeka Gumbi, Fransisca Xolisile Ceasar, Nasreen Ismail, Thumbi Ndung’u, Christina Gosmann, Musie S. Ghebremichael, Scott A. Handley, Caroline M. Mitchell, Alexandra-Chloé Villani, Douglas S. Kwon
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
The microbiome of the female genital tract (FGT) is closely linked to reproductive health outcomes. Diverse, anaerobe-dominated communities with low Lactobacillus abundance are associated with a number of adverse reproductive outcomes, such as preter
Externí odkaz:
https://doaj.org/article/86849ac40fd74dae97d282ac9d69d495
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Human immunodeficiency virus (HIV)-induced changes in immune cells during the acute phase of infection can cause irreversible immunological damage and predict the rate of disease progression. Antiretroviral therapy (ART) remains the most effective st
Externí odkaz:
https://doaj.org/article/bb14d78b04ad4f65b584476f3b7a342e
Autor:
Bonisile Luthuli, Kamini Gounder, Martin J. Deymier, Krista L. Dong, Alejandro B. Balazs, Jaclyn K. Mann, Thumbi Ndung'u
Publikováno v:
Virology. 583:14-26
Autor:
Ravesh Singh, Veron Ramsuran, Vivek Naranbhai, Nonhlanhla Yende-Zuma, Nigel Garrett, Koleka Mlisana, Krista L. Dong, Bruce D. Walker, Salim S. Abdool Karim, Mary Carrington, Thumbi Ndung’u
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
HIV-1 must overcome host antiviral restriction factors for efficient replication. We hypothesized that elevated levels of bone marrow stromal cell antigen 2 (BST-2), a potent host restriction factor that interferes with HIV-1 particle release in some
Externí odkaz:
https://doaj.org/article/c54a37bd881a413e9e5f2f105c2529ed