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pro vyhledávání: '"Krista K. Graven"'
Publikováno v:
American Journal of Physiology-Cell Physiology. 274:C347-C355
The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is induced by hypoxia in endothelial cells (EC). To define the mechanisms by which GAPDH is regulated by hypoxia, EC were exposed to cobalt, other transition metals, carbon monoxi
Autor:
Krista K. Graven, Harrison W. Farber
Publikováno v:
Kidney International. 51:426-437
Top of pageAbstract Moxonidine inhibits Na+/H+ exchange in proximal tubule cells and cortical collecting duct. The imidazoline receptor agonist moxonidine has been recently introduced as an antihypertensive therapy. Imidazoline specific binding sites
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 271:L341-L348
The mammalian response to cellular stresses often involves upregulation of certain stress proteins. This response is usually neither cell nor stress specific and sometimes results in cross-protection to other stresses. Endothelial cell (EC) hypoxia-a
Publikováno v:
Journal of Biological Chemistry. 270:27752-27757
The hypoxia-associated proteins (HAPs) are five cell-associated stress proteins (M(r) 34, 36, 39, 47, and 57) up-regulated in cultured vascular endothelial cells (EC) exposed to hypoxia. While hypoxic exposure of other cell types induces heat shock a
Publikováno v:
Journal of Biological Chemistry. 269:24446-24453
Exposure of endothelial cells (EC) to hypoxia results in the increased expression of a distinct set of proteins with molecular masses of 56, 47, 39, 36, and 34 kDa. Their induction appears to be unique to EC and the stress of decreased oxygen tension
Autor:
Jill S. Roncarati, Brian D. Klahn, Shawna L. Lowrey, Harrison W. Farber, Christopher Molvar, Krista K. Graven
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 282(5)
Endothelial cells (EC) exposed to hypoxia upregulate a unique set of five stress proteins. These proteins are upregulated in human and bovine aortic and pulmonary artery EC and are distinct from heat shock or glucose-regulated proteins. We previously
Publikováno v:
Biochimica et biophysica acta. 1447(2-3)
The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is induced by hypoxia in endothelial cells (EC). Upregulation occurs primarily at the level of transcription and occurs to a much greater extent in EC than in other cell types. To
Autor:
Krista K. Graven, Harrison W. Farber
Publikováno v:
The Journal of laboratory and clinical medicine. 132(6)
The vascular endothelium is an important mediator of vascular tone, inflammatory-immune reactions, vascular permeability, angiogenesis, and hemostasis. Endothelial functions may be altered by changes in the local cellular environment, particularly ch
Autor:
Leslie H. Zimmerman, Gerard L. Weinhouse, Krista K. Graven, Harrison W. Farber, Eric W. Dickson
Publikováno v:
Journal of cellular physiology. 157(3)
Vascular endothelial cells (EC) are one of the initial cells exposed to decreases in blood oxygen tension. Bovine EC respond not only by altering secretion of vasoactive, mitogenic, and thrombogenic substances, but also by developing adaptive mechani