Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Krista Erkkilä"'
Publikováno v:
Acta Paediatrica. 100:892-899
41 XXY mouse models share many characteristics of the human 47XXY Klinefelter syndrome (KS). This manuscript discusses the relative role of androgen deficiency and X chromosome genes resulting in the XXY mouse phenotype. The similarities in phenotype
Autor:
Ronald S. Swerdloff, Monica Schwarcz, Christina Wang, Amiya P. Sinha Hikim, Deena Abuyounes, Peter Liu, Krista Erkkilä, Yanhe Lue, J. David Jentsch, Paul W. N. Lee
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 299:E446-E455
XXY men (Klinefelter syndrome) are testosterone deficient, socially isolated, exhibit impaired gender identity, and may experience more homosexual behaviors. Here, we characterize social behaviors in a validated XXY mouse model to understand mechanis
Autor:
Ronald S. Swerdloff, Krista Erkkilä, Peter Liu, Kimberley Ma, Yanhe Lue, Christina Wang, Amiya P. Sinha Hikim
Publikováno v:
The American Journal of Pathology. 170:899-908
To assess adult stem cell differentiation in the testis, we injected bone marrow cells from adult green fluorescent protein (GFP) transgenic mice into the seminiferous tubules and the testicular interstitium of busulfan-treated wild-type or c-kit mut
Autor:
Mark Castanares, Krista Erkkilä, Yanira Vera, Ronald S. Swerdloff, Christina Wang, Amiya P. Sinha Hikim, Sauli Kyttänen, Yanhe Lue, Leo Dunkel
Publikováno v:
Biochemical and Biophysical Research Communications. 337:663-669
In this study, we determined the efficacy of minocycline, a second generation tetracycline, in preventing male germ cell apoptosis after withdrawal of gonadotropins and intratesticular testosterone (T). Groups of 5 male rats received one of the follo
Effects of Acid Sphingomyelinase Deficiency on Male Germ Cell Development and Programmed Cell Death1
Autor:
Krista Erkkilä, Gloria I. Perez, Tiina Matikainen, Markku O. Pentikäinen, Petri T. Kovanen, Mikko Tenhunen, Jukka K. Hakala, Marjut Otala, Martti Parvinen, Leo Dunkel, Laura Suomalainen
Publikováno v:
Biology of Reproduction. 72:86-96
Deficiency of acid sphingomyelinase (ASM), an enzyme responsible for producing a pro-apoptotic second messenger ceramide, has previously been shown to promote the survival of fetal mouse oocytes in vivo and to protect oocytes from chemotherapy-induce
Autor:
Virve Pentikäinen, Minna Eriksson, Leo Dunkel, Riina Oksjoki, Kimmo Taari, Krista Erkkilä, Markku Heikinheimo, Ilkka Ketola, Laura Suomalainen
Publikováno v:
MHR: Basic science of reproductive medicine. 10:743-753
Apoptosis limits germ cell number in the testis, and its dysregulation is associated with male infertility. Here, we evaluated the role of the transcription factor activator protein 1 (AP-1) in male germ cell apoptosis in a culture of human seminifer
Autor:
Laura Suomalainen, Petri T. Kovanen, Jorma Toppari, Mikko Tenhunen, Markku O. Pentikäinen, Leo Dunkel, Marjut Otala, Krista Erkkilä
Publikováno v:
Biology of Reproduction. 70:759-767
Male germ cells are susceptible to radiation-induced injury, and infertility is a common problem after total-body irradiation. Here we investigated, first, the effects of irradiation on germ cells in mouse testis and, second, the role of sphingosine-
Autor:
Markku O. Pentikäinen, Krista Erkkilä, Leo Dunkel, Jukka K. Hakala, Marjut Otala, Virve Pentikäinen, Laura Suomalainen
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 88:5572-5579
It has been suggested that apoptosis is controlled by two intracellular sphingolipids, ceramide and sphingosine-1-phosphate (S1P), which are widely distributed in mammalian tissues. In the ovary, S1P was found to effectively block apoptosis caused by
Publikováno v:
Biology of Reproduction. 69:617-626
An understanding of testicular physiology and pathology requires knowledge of the regulation of cell death. Previous observation of suppression of apoptosis by hypoxia suggested a role for ATP in germ cell death. However, the exact effects of ATP pro
Publikováno v:
Molecular Human Reproduction. 8:109-117
Dysregulation of male germ cell apoptosis has been associated with the pathogenesis of male infertility. Therefore, factors involved in the regulation of germ cell death are being actively investigated. Here, we studied the effects of lactate on huma