Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Krista Condon"'
Autor:
Kenichi Nomoto, Mary Woodall-Jappe, Toshimitsu Uenaka, William H. Gerwick, Yoshihiko Kotake, Hajime Shimizu, Xiaojie Zhu, Hyeong-wook Choi, Steven Mathieu, Kuo-Ming Wu, Yongchun Shen, Karen Tendyke, Sergei Agoulnik, Krista Condon, Donna Kolber-Simonds, Sandeep Akare, Yimin Jiang, Zhihong Chen, Kuan-Chun Huang
Figure S1. Synthesis of [3H]apratoxin A. Figure S2. Synthesis of C.18-epi-apratoxin A. Figure S3. Apratoxin A in vitro IC50 against panels of human cancer cell lines. Table S1. Summary table for in vivo efficacy studies. Figure S4. Apratoxin A concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c65eb6f8b62874049a2fbbb2e9b798
https://doi.org/10.1158/1535-7163.22504099.v1
https://doi.org/10.1158/1535-7163.22504099.v1
Autor:
Kenichi Nomoto, Mary Woodall-Jappe, Toshimitsu Uenaka, William H. Gerwick, Yoshihiko Kotake, Hajime Shimizu, Xiaojie Zhu, Hyeong-wook Choi, Steven Mathieu, Kuo-Ming Wu, Yongchun Shen, Karen Tendyke, Sergei Agoulnik, Krista Condon, Donna Kolber-Simonds, Sandeep Akare, Yimin Jiang, Zhihong Chen, Kuan-Chun Huang
Apratoxin A is a natural product with potent antiproliferative activity against many human cancer cell lines. However, we and other investigators observed that it has a narrow therapeutic window in vivo. Previous mechanistic studies have suggested it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1702da5e1eb71b2ce4a697dd456e12e0
https://doi.org/10.1158/1535-7163.c.6537622.v1
https://doi.org/10.1158/1535-7163.c.6537622.v1
Autor:
Kenichi Nomoto, Mary Woodall-Jappe, Toshimitsu Uenaka, William H. Gerwick, Yoshihiko Kotake, Hajime Shimizu, Xiaojie Zhu, Hyeong-wook Choi, Steven Mathieu, Kuo-Ming Wu, Yongchun Shen, Karen Tendyke, Sergei Agoulnik, Krista Condon, Donna Kolber-Simonds, Sandeep Akare, Yimin Jiang, Zhihong Chen, Kuan-Chun Huang
Figure S1. Synthesis of [3H]apratoxin A. Figure S2. Synthesis of C.18-epi-apratoxin A. Figure S3. Apratoxin A in vitro IC50 against panels of human cancer cell lines. Table S1. Summary table for in vivo efficacy studies. Figure S4. Apratoxin A concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f53f6e76b6cb66b04a95e5af1c1cb98
https://doi.org/10.1158/1535-7163.22504102
https://doi.org/10.1158/1535-7163.22504102
Autor:
Barbara S. Slusher, Michael Polydefkis, Guido Cavaletti, Stuart C. Feinstein, Mary A. Jordan, Leslie Wilson, Christopher DesJardins, Sean Eckley, Krista Condon, Kenichi Nomoto, Bruce A. Littlefield, Brett M. Cook, Sara Semperboni, Eleonora Pozzi, Paola Alberti, Elisa Ballarini, Virginia Rodriguez-Menendez, Valentina A. Carozzi, Ying Liu, Ying Wu, James J. Vornov, Krystyna M. Wozniak
File contains description of supplementary methods used for sciatic nerve immunofluorescence data generation and quantification with Supplementary Fig 1 showing how raw fluorescence intensity values were normalized in order to compare levels of acety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c8fe14a2eaf120d0d4176f58a513a6
https://doi.org/10.1158/0008-5472.22417085
https://doi.org/10.1158/0008-5472.22417085
Autor:
Barbara S. Slusher, Michael Polydefkis, Guido Cavaletti, Stuart C. Feinstein, Mary A. Jordan, Leslie Wilson, Christopher DesJardins, Sean Eckley, Krista Condon, Kenichi Nomoto, Bruce A. Littlefield, Brett M. Cook, Sara Semperboni, Eleonora Pozzi, Paola Alberti, Elisa Ballarini, Virginia Rodriguez-Menendez, Valentina A. Carozzi, Ying Liu, Ying Wu, James J. Vornov, Krystyna M. Wozniak
Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of disability in cancer survivors. CIPN investigations in preclinical model systems have focused on either behaviors or acute changes in nerve conduction velocity (NCV) and amplitude,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ede1532c2b073e39e9d7c1ef288c76
https://doi.org/10.1158/0008-5472.c.6509738
https://doi.org/10.1158/0008-5472.c.6509738
Autor:
Kazutomi Kusano, Edgar Schuck, Michiko Sugawara, W. George Lai, Krista Condon, Christopher DesJardins, Earvin Liang
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Eribulin, a synthetic analog of the natural product halichondrin B, is a microtubule dynamics inhibitor. In this study, we report the pharmacokinetic profiles of eribulin in mice, rats, and dogs following intravenous administrations with opti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ef759ac56c4692d3956619e24f99fe
https://doi.org/10.1007/s00280-017-3369-7
https://doi.org/10.1007/s00280-017-3369-7
Autor:
Kenichi Nomoto, Kuo Ming Wu, Xiaojie Zhu, Sergei Agoulnik, Donna Kolber-Simonds, Kuan-Chun Huang, Steven Mathieu, Toshimitsu Uenaka, Sandeep Akare, Yongchun Shen, Yoshihiko Kotake, William H. Gerwick, Zhihong Chen, Hyeong-Wook Choi, Karen TenDyke, Yimin Jiang, Krista Condon, Mary Woodall-Jappe, Hajime Shimizu
Publikováno v:
Molecular Cancer Therapeutics. 15:1208-1216
Apratoxin A is a natural product with potent antiproliferative activity against many human cancer cell lines. However, we and other investigators observed that it has a narrow therapeutic window in vivo. Previous mechanistic studies have suggested it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5b7bfdb06dfb6c13edeb29b73304c4
https://doi.org/10.1158/1535-7163.mct-15-0648
https://doi.org/10.1158/1535-7163.mct-15-0648
Autor:
James J. Vornov, Michael Polydefkis, Sean Eckley, Ying Wu, Krista Condon, Brett M. Cook, S. Semperboni, Stuart C. Feinstein, Christopher DesJardins, Paola Alberti, Valentina Alda Carozzi, Virginia Rodriguez-Menendez, Bruce A. Littlefield, Krystyna M. Wozniak, Ying Liu, Leslie Wilson, Elisa Ballarini, Mary Ann Jordan, Barbara S. Slusher, Guido Cavaletti, Eleonora Pozzi, Kenichi Nomoto
Publikováno v:
Cancer research, vol 78, iss 3
Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of disability in cancer survivors. CIPN investigations in preclinical model systems have focused on either behaviors or acute changes in nerve conduction velocity (NCV) and amplitude,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90106f328bc268d46c1a9a24033ed90b
http://hdl.handle.net/10281/176047
http://hdl.handle.net/10281/176047
Autor:
Curtis B. Thompson, Bruce A. Littlefield, Susan Zimmerman, Daniel C. Maneval, Krista Condon, A Fathallah, Jesse Bahn, Christopher DesJardins
Publikováno v:
Cancer Research. 76:P1-03
Hyaluronan (hyaluronic acid, HA), a glycosaminoglycan found in tissue throughout the body, overaccumulates in the tumor microenvironment (TME) of many non-hematologic malignancies, including breast cancer. HA overaccumulation in breast cancer patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15eb86048249b99ab6d2117081b3c2e4
https://doi.org/10.1158/1538-7445.sabcs15-p1-03-09
https://doi.org/10.1158/1538-7445.sabcs15-p1-03-09
Autor:
Boris M. Seletsky, Karen TenDyke, Sean Eckley, Bruce A. Littlefield, Huiming Zhang, Hong Du, Carlson Eric, Wanjun Zheng, Yimin Jiang, Sridhar Narayan, Murray J. Towle, Yongbo Hu, Edgar Schuck, Krista Condon, Vipul Kumar, Hongsheng Cheng, Bryan M. Lewis, Philip Saxton, Melvin J. Yu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1639-1643
Novel second generation analogs of eribulin mesylate, a tubulin agent recently approved for the treatment of breast cancer, are reported. Our recent efforts have focused on expanding the target indications for this class of compounds to other tumor t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62257f5a6af666cc068a87029b501218
https://doi.org/10.1016/j.bmcl.2011.01.096
https://doi.org/10.1016/j.bmcl.2011.01.096