Potent dual block to HIV-1 infection using lentiviral vectors expressing fusion inhibitor peptide mC46- and Vif-resistant APOBEC3G

Autor: Krista A. Delviks-Frankenberry, Chet R. Ojha, Kip J. Hermann, Wei-Shau Hu, Bruce E. Torbett, Vinay K. Pathak

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 794-809 (2023)

Gene therapy strategies that effectively inhibit HIV-1 replication are needed to reduce the requirement for lifelong antiviral therapy and potentially achieve a functional cure. We previously designed self-activating lentiviral vectors that efficient

Externí odkaz: https://doaj.org/article/70c860cc373b40bdaec6dcc5a4b940e3

Development of Lentiviral Vectors for HIV-1 Gene Therapy with Vif-Resistant APOBEC3G

Autor: Krista A. Delviks-Frankenberry, Daniel Ackerman, Nina D. Timberlake, Maria Hamscher, Olga A. Nikolaitchik, Wei-Shau Hu, Bruce E. Torbett, Vinay K. Pathak

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 1023-1038 (2019)

Strategies to control HIV-1 replication without antiviral therapy are needed to achieve a functional cure. To exploit the innate antiviral function of restriction factor cytidine deaminase APOBEC3G (A3G), we developed self-activating lentiviral vecto

Externí odkaz: https://doaj.org/article/8ce3c38bfdec4df3802934eb69e6970d

The 'Connection' Between HIV Drug Resistance and RNase H

Autor: Krista A. Delviks-Frankenberry, Vinay K. Pathak, Galina N. Nikolenko

Publikováno v: Viruses, Vol 2, Iss 7, Pp 1476-1503 (2010)

Currently, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) are two classes of antiretroviral agents that are approved for treatment of HIV-1 infection. Since both NRTIs and NNRTIs target

Externí odkaz: https://doaj.org/article/5d55f51a94c846dabcc84cbf0d6fa163

Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity

Autor: Krista A. Delviks-Frankenberry, Olusegun O. Onabajo, Seraph Han-Yin Lin, Vinay K. Pathak, Ariunaa Bayanjargal, Oscar Florez-Vargas, Joselin M. Vargas, Clara Zettelmeyer, Philippe Lamy, Lars Dyrskjøt, A. Rouf Banday, Adeola Obajemu, Ludmila Prokunina-Olsson

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Communications Biology
Rouf Banday, A, Onabajo, O O, Lin, S H Y, Obajemu, A, Vargas, J M, Delviks-Frankenberry, K A, Lamy, P, Bayanjargal, A, Zettelmeyer, C, Florez-Vargas, O, Pathak, V K, Dyrskjøt, L & Prokunina-Olsson, L 2021, ' Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity ', Communications Biology, vol. 4, no. 1, 386 . https://doi.org/10.1038/s42003-021-01844-5

APOBEC3A (A3A) and APOBEC3B (A3B) enzymes drive APOBEC-mediated mutagenesis. Identification of factors affecting the activity of these enzymes could help modulate mutagenesis and associated clinical outcomes. Here, we show that canonical and alternat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6031aa58382abe731ed6bd22683708
https://doaj.org/article/c4fee0bc579f4d40a8783a55e109bac9

Crystal Structure of a Soluble APOBEC3G Variant Suggests ssDNA to Bind in a Channel that Extends between the Two Domains

Autor: Nese Kurt Yilmaz, Rashmi Tripathi, Shurong Hou, Wazo Myint, Hiroshi Matsuo, Christina Sierra Rodriguez, Vinay K. Pathak, Krista A. Delviks-Frankenberry, Vanivilasini Balachandran, Atanu Maiti, Celia A. Schiffer, Tapan Kanai

Publikováno v: J Mol Biol

APOBEC3G (A3G) is a single-stranded DNA (ssDNA) cytosine deaminase that can restrict HIV-1 infection by mutating the viral genome. A3G consists of a non-catalytic N-terminal domain (NTD) and a catalytic C-terminal domain (CTD) connected by a short li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348b386bee6f1275ca4f2879165b9099
https://pubmed.ncbi.nlm.nih.gov/33098858