Identifying obstacles hindering the conduct of academic-sponsored trials for drug repurposing on rare-diseases: an analysis of six use cases

Autor: Marta del Álamo, Christoph Bührer, Dirk Fisher, Matthias Griese, Paul Lingor, Giovanni Palladini, Nicolas Sireau, Virginie Hivert, Luca Sangiorgi, Florence Guillot, Juliane Halftermeyer, Lenka Soucková, Kristýna Nosková, Regina Demlová

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-10 (2022)

Abstract Background Academic-sponsored trials for rare diseases face many challenges; the present paper identifies hurdles in the set-up of six multinational clinical trials for drug repurposing, as use cases. Methods Six academic-sponsored multinati

Externí odkaz: https://doaj.org/article/aa7ef21410884d95a66ff184ad0ef663

Lycopene increases metabolic activity of rat liver CYP2B, CYP2D and CYP3A

Autor: Kristýna, Nosková, Gabriela, Dovrtělová, Ondřej, Zendulka, Markéta, Strakošová, Ondřej, Peš, Jan, Juřica

Publikováno v: Pharmacological reports : PR. 72(1)

Lycopene as a naturally occurring carotenoid is a common part of the human diet. Several beneficial properties of lycopene have been identified, with the most studied being anti-cancer and antioxidant activity. However, no evidence of possible drug-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb70b96f09f62930f00a0718fccaaf53
https://pubmed.ncbi.nlm.nih.gov/32016858

The effect of (-)-linalool on the metabolic activity of liver CYP enzymes in rats

Autor: Roman Řemínek, Kristýna Nosková, Jan Juřica, Ondřej Zendulka, Gabriela Přibyl Dovrtělová

Publikováno v: ResearcherID
Scopus-Elsevier

(-)-Linalool is the major floral scent occurring mainly in families Lamiaceae, Lauraceae and Rutaceae and is the main active compound of lavender oil. The purpose of this study was to reveal the influence of subchronic systemic treatment with (-)-lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9754ece77b09aee0b5c8a336b1e3d245
https://pubmed.ncbi.nlm.nih.gov/28006932

Can bioactive compounds of Crocus sativus L. Influence the metabolic activity of selected CYP enzymes in the rat?

Autor: Ondřej Zendulka, Kristýna Nosková, Jan Juřica, Miroslav Turjap, Gabriela Přibyl Dovrtělová

Publikováno v: Scopus-Elsevier
Europe PubMed Central
ResearcherID

Safranal and crocin are biologically active compounds isolated from Crocus sativus L., commonly known as saffron. Clinical trials confirm that saffron has antidepressant effect, thus being a potential valuable alternative in the treatment of depressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860c4c9504d5c9914ccf3ad8c67c5360
http://www.scopus.com/inward/record.url?eid=2-s2.0-84983097422&partnerID=MN8TOARS

Identifying obstacles hindering the conduct of academic-sponsored trials for drug repurposing on rare-diseases: an analysis of six use cases.

Autor: del Álamo, Marta¹ (AUTHOR) marta.delalamo@ecrin.org, Bührer, Christoph² (AUTHOR), Fisher, Dirk³ (AUTHOR), Griese, Matthias⁴ (AUTHOR), Lingor, Paul⁵ (AUTHOR), Palladini, Giovanni⁶ (AUTHOR), Sireau, Nicolas⁷ (AUTHOR), Hivert, Virginie⁸ (AUTHOR), Sangiorgi, Luca⁹ (AUTHOR), Guillot, Florence¹⁰ (AUTHOR), Halftermeyer, Juliane¹¹ (AUTHOR), Soucková, Lenka^1,12 (AUTHOR), Nosková, Kristýna^1,12 (AUTHOR), Demlová, Regina¹² (AUTHOR)

Publikováno v: Trials. 9/15/2022, Vol. 23 Issue 1, p1-10. 10p. 3 Charts.