Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations

Autor: Perez-Lopez, Aron R., Szalay, Kristof Z., Turei, Denes, Modos, Dezso, Lenti, Katalin, Korcsmaros, Tamas, Csermely, Peter

Publikováno v: Scientific Reports 5, 10182 (2015)

Network-based methods are playing an increasingly important role in drug design. Our main question in this paper was whether the efficiency of drug target proteins to spread perturbations in the human interactome is larger if the binding drugs have s

Externí odkaz: http://arxiv.org/abs/1504.00272

Attractor structures of signaling networks: Consequences of different conformational barcode dynamics and their relations to network-based drug design

Autor: Szalay, Kristof Z., Nussinov, Ruth, Csermely, Peter

Publikováno v: Molecular Informatics (2014) 33: 463-468

Conformational barcodes tag functional sites of proteins, and are decoded by interacting molecules transmitting the incoming signal. Conformational barcodes are modified by all co-occurring allosteric events induced by post-translational modification

Externí odkaz: http://arxiv.org/abs/1404.4515

Potential application of network descriptions for understanding conformational changes and protonation states of ABC transporters

Autor: Hegedus, Tamas, Gyimesi, Gergely, Gaspar, Merse E., Szalay, Kristof Z., Gangal, Rajeev, Csermely, Peter

Publikováno v: Current Pharmaceutical Design, 2013, 19, 4155-4172

The ABC (ATP Binding Cassette) transporter protein superfamily comprises a large number of ubiquitous and functionally versatile proteins conserved from archaea to humans. ABC transporters have a key role in many human diseases and also in the develo

Externí odkaz: http://arxiv.org/abs/1206.0123

Morpho-Anatomical, Physiological and Biochemical Adjustments in Response to Heat and Drought Co-Stress in Winter Barley.

Autor: Jampoh EA; Biological Resources Department, HUN-REN Centre for Agricultural Research, 2462 Martonvásár, Hungary.; Doctoral School of Horticultural Sciences, MATE Hungarian University of Agriculture and Life Sciences, 2100 Gödöllő, Hungary., Sáfrán E; Biological Resources Department, HUN-REN Centre for Agricultural Research, 2462 Martonvásár, Hungary., Babinyec-Czifra D; Biological Resources Department, HUN-REN Centre for Agricultural Research, 2462 Martonvásár, Hungary.; Doctoral School of Biology, Institute of Biology, ELTE Eötvös Loránd University, 1053 Budapest, Hungary., Kristóf Z; Department of Plant Anatomy, ELTE Eötvös Loránd University, 1053 Budapest, Hungary., Krárné Péntek B; Biological Resources Department, HUN-REN Centre for Agricultural Research, 2462 Martonvásár, Hungary., Fábián A; Biological Resources Department, HUN-REN Centre for Agricultural Research, 2462 Martonvásár, Hungary., Barnabás B; Biological Resources Department, HUN-REN Centre for Agricultural Research, 2462 Martonvásár, Hungary., Jäger K; Biological Resources Department, HUN-REN Centre for Agricultural Research, 2462 Martonvásár, Hungary.

Publikováno v: Plants (Basel, Switzerland) [Plants (Basel)] 2023 Nov 20; Vol. 12 (22). Date of Electronic Publication: 2023 Nov 20.

Transposon-Derived Organ-Specific Mutation in the ADH1 RNA 5' Untranslated Leader of Autotetraploid Maize (Zea mays L.)

Autor: Hajós-Novák, M., Dallmann, G., Kristóf, Z.

Publikováno v: Cereal Research Communications, 2009 Jun 01. 37(2), 151-158.

Externí odkaz: https://www.jstor.org/stable/23790015