Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Krist'l Vennekens"'
Autor:
Samir Kumar-Singh, Ann Julliams, Rony Nuydens, Chantal Ceuterick, Christine Labeur, Sally Serneels, Krist'l Vennekens, Peter Van Osta, Hugo Geerts, Bart De Strooper, Christine Van Broeckhoven
Publikováno v:
Neurobiology of Disease, Vol 11, Iss 2, Pp 330-340 (2002)
Mutations in the β-amyloid (Aβ) sequence of the amyloid precursor protein gene (APP) present with variable disease phenotypes. While patients with the Dutch APP mutation (E693Q) have predominantly hemorrhagic strokes, Flemish APP (A692G) patients d
Externí odkaz:
https://doaj.org/article/9dad1697dacf48c3833b0f7b8bcacb3a
Autor:
Jean Jacques Martin, Rik Vandenberghe, Marc Cruts, Ivy Cuijt, Samir Kumar-Singh, U. Lübke, Chantal Ceuterick, Daniel Pirici, Rosa Rademakers, Bart Dermaut, Christine Van Broeckhoven, Krist'l Vennekens
Publikováno v:
ResearcherID
Journal of neuropathology and experimental neurology
Journal of neuropathology and experimental neurology
The most common histologic feature in patients with frontotemporal lobar degeneration (FTLD) is intracellular brain inclusions of yet uncharacterized proteins that react with antiubiquitin (Ub) antibodies, but not with tau or synuclein (FTLD-U). We i
Autor:
Samir Kumar-Singh, Barbara A. Pickut, Marleen Van den Broeck, Karin Peeters, Jos Saerens, Jessie Theuns, Patrick Cras, Peter Paul De Deyn, Marc Cruts, Jean Jacques Martin, Bart Dermaut, Krist'l Vennekens, S. Engelborghs, Christine Van Broeckhoven, Stephen Claes, Rosa Rademakers
Publikováno v:
Annals of neurology
Europe PubMed Central
Europe PubMed Central
Familial forms of frontotemporal dementia (FTD) with tauopathy are mostly caused by mutations in the gene encoding the microtubule-associated protein tau (MAPT). However, rare forms of familial tauopathy without MAPT mutations have been reported, sug
Autor:
Francesc X. Guix, Danyelle M. Townsend, Sebastian Munck, Colin Dingwall, Bart De Strooper, Krist'l Vennekens, Kenneth D. Tew, John B. Davis, Tina Wahle, Fabian Feiguin, Vasiliki Michaki, Carlos G. Dotti
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Clinical, pharmacological, biochemical, and genetic evidence support the notion that alteration of cholesterol homeostasis strongly predisposes to Alzheimer disease (AD). The ATP-binding cassette transporter-2 (Abca2), which plays a role in intracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680cca549dd90002a69190a742d21aa9
http://hdl.handle.net/10261/112323
http://hdl.handle.net/10261/112323
Autor:
Iva, Nesic, Francesc X, Guix, Krist'l, Vennekens, Vasiliki, Michaki, Paul P, Van Veldhoven, Fabian, Feiguin, Bart, De Strooper, Carlos G, Dotti, Tina, Wahle
Publikováno v:
Aging cell. 11(1)
Several studies suggest that the generation of Aβ is highly dependent on the levels of cholesterol within membranes' detergent-resistant microdomains (DRM). Indeed, the β-amyloid precursor protein (APP) cleaving machinery, namely β- and γ-secreta
Autor:
Annette, Gärtner, Eugenio F, Fornasiero, Sebastian, Munck, Krist'l, Vennekens, Eve, Seuntjens, Wieland B, Huttner, Flavia, Valtorta, Carlos G, Dotti
Publikováno v:
The EMBO journal. 31(8)
The precise polarization and orientation of developing neurons is essential for the correct wiring of the brain. In pyramidal excitatory neurons, polarization begins with the sprouting of opposite neurites, which later define directed migration and a
Autor:
Samir Kumar-Singh, Krist'l Vennekens, Bianca Van Broeck, Jessie Theuns, Bart Dermaut, Rong Wang, Daniel Pirici, Marc Cruts, Christine Van Broeckhoven, Ellen Corsmit
Publikováno v:
Alzheimer's & Dementia. 2
Autor:
Jean-Jacques Martin, Krist'l Vennekens, Julie van der Zee, Ivy Cuijt, Samir Kumar-Singh, Christine Van Broeckhoven, Chantal Ceuterick, Rosa Rademakers, Rik Vandenberghe, U. Lübke, Daniel Pirici
Publikováno v:
Alzheimer's & Dementia. 2
Autor:
Debby Van Dam, Andrej Michalik, Hans Wils, Ivy Cuijt, Bianca Van Broeck, Christine Van Broeckhoven, Annemie Van der Linden, Jessie Theuns, Samir Kumar-Singh, Daniel Pirici, Monika Zabielski, Peter Paul De Deyn, Krist'l Vennekens, Greet Vanhoutte
Publikováno v:
Neurobiology of aging
Transgenic mouse models of Alzheimer's disease (AD) expressing high levels of amyloid precursor protein (APP) with familial AD (FAD) mutations have proven to be extremely useful in understanding pathogenic processes of AD especially those that involv
Autor:
Rik Vandenberghe, Nathalie Brouwers, M Van den Broeck, Marc Cruts, C. Van Broeckhoven, Mathieu Vandenbulcke, Els Marjaux, B. De Strooper, J. Theuns, K. Van Laere, Ellen Corsmit, Samir Kumar-Singh, Guy Bormans, Krist'l Vennekens
Publikováno v:
Human mutation
Since the first report showing that Alzheimer disease (AD) might be caused by mutations in the amyloid precursor protein gene (APP), 20 different missense mutations have been reported. The majority of early-onset AD mutations alter processing of APP