Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Krissie Lenting"'
Autor:
Krissie Lenting, Corina N. A. M. van den Heuvel, Anne van Ewijk, Duaa ElMelik, Remco de Boer, Elizabeth Tindall, Ge Wei, Benno Kusters, Maarten te Dorsthorst, Mark ter Laan, Martijn A. Huynen, William P. Leenders
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Many biology-based precision drugs are available that neutralize aberrant molecular pathways in cancer. Molecular heterogeneity and the lack of reliable companion diagnostic biomarkers for many drugs makes targeted treatment of cancer inaccu
Externí odkaz:
https://doaj.org/article/295b2e41b8a84f889a698d9f2d2d97e1
Autor:
Tom H. Peeters, Krissie Lenting, Vincent Breukels, Sanne A. M. van Lith, Corina N. A. M. van den Heuvel, Remco Molenaar, Arno van Rooij, Ron Wevers, Paul N. Span, Arend Heerschap, William P. J. Leenders
Publikováno v:
Cancer & Metabolism, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Background Mutations in isocitrate dehydrogenase 1 (IDH1) occur in various types of cancer and induce metabolic alterations resulting from the neomorphic activity that causes production of D-2-hydroxyglutarate (D-2-HG) at the expense of α-k
Externí odkaz:
https://doaj.org/article/134a2d6836154e8195617e7ff0cbfff9
Autor:
Cornelis J. van Noorden, Fonnet E. Bleeker, William P. Leenders, W. Peter Vandertop, Jaroslaw P. Maciejewski, Johanna W. Wilmink, Tomas Radivoyevitch, Ron A. Hoebe, Cornelis M. van Drunen, Dionysia Dimitrakopoulou, Adri N. Mul, Krissie Lenting, Mohammed Khurshed, Peter Henneman, Jan Stap, Sanne A. van Lith, Vashendriya V. Hira, Myrthe A. Smits, Dennis Botman, Remco J. Molenaar
D-2HG inhibits IDH-mediated NADPH production capacity, but not G6PD-mediated NADPH production capacity or IDH-mediated NADH production capacity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c00fef62eafc6548de46176770adc97
https://doi.org/10.1158/0008-5472.22412280.v1
https://doi.org/10.1158/0008-5472.22412280.v1
Autor:
Cornelis J. van Noorden, Fonnet E. Bleeker, William P. Leenders, W. Peter Vandertop, Jaroslaw P. Maciejewski, Johanna W. Wilmink, Tomas Radivoyevitch, Ron A. Hoebe, Cornelis M. van Drunen, Dionysia Dimitrakopoulou, Adri N. Mul, Krissie Lenting, Mohammed Khurshed, Peter Henneman, Jan Stap, Sanne A. van Lith, Vashendriya V. Hira, Myrthe A. Smits, Dennis Botman, Remco J. Molenaar
SPSS output statistics for comparisons between survival curves from colony-formation assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d1222c3980f828fe4ee1f14a765f79
https://doi.org/10.1158/0008-5472.22412268.v1
https://doi.org/10.1158/0008-5472.22412268.v1
Autor:
Cornelis J. van Noorden, Fonnet E. Bleeker, William P. Leenders, W. Peter Vandertop, Jaroslaw P. Maciejewski, Johanna W. Wilmink, Tomas Radivoyevitch, Ron A. Hoebe, Cornelis M. van Drunen, Dionysia Dimitrakopoulou, Adri N. Mul, Krissie Lenting, Mohammed Khurshed, Peter Henneman, Jan Stap, Sanne A. van Lith, Vashendriya V. Hira, Myrthe A. Smits, Dennis Botman, Remco J. Molenaar
Isocitrate dehydrogenase 1 (IDH1) is mutated in various types of human cancer to IDH1R132H, a structural alteration that leads to catalysis of α-ketoglutarate to the oncometabolite D-2-hydroxyglutarate. In this study, we present evidence that small-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5c1fa1f1ef7af279dc9e5e587d4809e
https://doi.org/10.1158/0008-5472.c.6508407.v1
https://doi.org/10.1158/0008-5472.c.6508407.v1
Autor:
Corina N. A. M. van den Heuvel, Arend Heerschap, Kiek Verrijp, Wiljan Hendriks, Paul N. Span, Martijn A. Huynen, Cornelis J.F. Van Noorden, Mohammed Khurshed, Krissie Lenting, Benno Küsters, Remco J. Molenaar, Tom H Peeters, Anne van Ewijk, William P.J. Leenders, Mark ter Laan, Tessa J. J. de Bitter, Sanne A. M. van Lith, Dennis Botman
Publikováno v:
FASEB journal, 33(1), 557-571. FASEB
The Faseb Journal, 33, 1, pp. 557-571
The Faseb Journal, 33, 557-571
The Faseb Journal, 33, 1, pp. 557-571
The Faseb Journal, 33, 557-571
Contains fulltext : 202248.pdf (Publisher’s version ) (Closed access) Diffuse gliomas often carry point mutations in isocitrate dehydrogenase ( IDH1(mut)), resulting in metabolic stress. Although IDH(mut) gliomas are difficult to culture in vitro,
Autor:
Krissie Lenting, Mohammed Khurshed, William P.J. Leenders, Remco J. Molenaar, Cornelis J.F. Van Noorden
Publikováno v:
Oncotarget, 8, 49165-49177
Oncotarget, 8(30), 49165-49177. Impact Journals
Oncotarget, 8, 30, pp. 49165-49177
Oncotarget
Oncotarget, 8(30), 49165-49177. Impact Journals
Oncotarget, 8, 30, pp. 49165-49177
Oncotarget
Item does not contain fulltext Hotspot mutations in isocitrate dehydrogenase 1 (IDH1) initiate low-grade glioma and secondary glioblastoma and induce a neomorphic activity that converts alpha-ketoglutarate (alpha-KG) to the oncometabolite D-2-hydroxy
Autor:
Krissie Lenting, Heuvel, Corina, Ewijk, Anne, Duaa ElMelik, Boer, Remco, Tindall, Elizabeth, Wei, Ge, Kusters, Benno, Dorsthorst, Maarten, Laan, Mark, Huynen, Martijn, Leenders, William
Additional file 4: Table S3. Differential gene expression in IDHIDHwt gliomas from cluster B vs cluster A. A total of 4 genes were differentially expressed between the cluster A and the IDHIDHwt gliomas that grouped in cluster B. Only genes that were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445cd741df9ae7941545554e7b6e3982
Autor:
Arno van Rooij, Sanne A. M. van Lith, Arend Heerschap, Krissie Lenting, William P.J. Leenders, Remco J. Molenaar, Ron A. Wevers, Tom H Peeters, Paul N. Span, Corina N. A. M. van den Heuvel, Vincent Breukels
Publikováno v:
Cancer & Metabolism, 7
Cancer & Metabolism
Cancer & Metabolism, Vol 7, Iss 1, Pp 1-13 (2019)
Cancer & Metabolism
Cancer & Metabolism, Vol 7, Iss 1, Pp 1-13 (2019)
Background Mutations in isocitrate dehydrogenase 1 (IDH1) occur in various types of cancer and induce metabolic alterations resulting from the neomorphic activity that causes production of D-2-hydroxyglutarate (D-2-HG) at the expense of α-ketoglutar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa245348ad7660eec9c5954e9dbee93
https://hdl.handle.net/2066/204013
https://hdl.handle.net/2066/204013
Autor:
Dennis Botman, Johanna W. Wilmink, Fonnet E. Bleeker, Tomas Radivoyevitch, Jaroslaw P. Maciejewski, Remco J. Molenaar, Cornelis M. van Drunen, W. Peter Vandertop, Cornelis J.F. Van Noorden, Myrthe A.J. Smits, Mohammed Khurshed, Jan Stap, William P.J. Leenders, Sanne A. M. van Lith, Krissie Lenting, Dionysia Dimitrakopoulou, Vashendriya V V Hira, Peter Henneman, Ron A. Hoebe, Adri Mul
Publikováno v:
Cancer Research, 75, 22, pp. 4790-802
Cancer Research, 75(22), 4790-4802. American Association for Cancer Research Inc.
Cancer research, 75(22), 4790-4802. American Association for Cancer Research Inc.
Molenaar, R J, Botman, D, Smits, M A, Hira, V V, van Lith, S A, Stap, J, Henneman, P, Khurshed, M, Lenting, K, Mul, A N, Dimitrakopoulou, D, van Drunen, C M, Hoebe, R A, Radivoyevitch, T, Wilmink, J W, Maciejewski, J P, Vandertop, W P, Leenders, W P, Bleeker, F E & van Noorden, C J 2015, ' Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198 ', Cancer Research, vol. 75, no. 22, pp. 4790-4802 . https://doi.org/10.1158/0008-5472.CAN-14-3603
Cancer Research, 75, 4790-802
Cancer Research, 75(22), 4790-4802. American Association for Cancer Research Inc.
Cancer research, 75(22), 4790-4802. American Association for Cancer Research Inc.
Molenaar, R J, Botman, D, Smits, M A, Hira, V V, van Lith, S A, Stap, J, Henneman, P, Khurshed, M, Lenting, K, Mul, A N, Dimitrakopoulou, D, van Drunen, C M, Hoebe, R A, Radivoyevitch, T, Wilmink, J W, Maciejewski, J P, Vandertop, W P, Leenders, W P, Bleeker, F E & van Noorden, C J 2015, ' Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198 ', Cancer Research, vol. 75, no. 22, pp. 4790-4802 . https://doi.org/10.1158/0008-5472.CAN-14-3603
Cancer Research, 75, 4790-802
Isocitrate dehydrogenase 1 (IDH1) is mutated in various types of human cancer to IDH1R132H, a structural alteration that leads to catalysis of α-ketoglutarate to the oncometabolite D-2-hydroxyglutarate. In this study, we present evidence that small-