Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Krisna C Duong-Ly"'
Autor:
Andres H de la Peña, Allison Suarez, Krisna C Duong-Ly, Andrew J Schoeffield, Mario A Pizarro-Dupuy, Melissa Zarr, Silvia A Pineiro, L Mario Amzel, Sandra B Gabelli
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141716 (2015)
Given the broad range of substrates hydrolyzed by Nudix (nucleoside diphosphate linked to X) enzymes, identification of sequence and structural elements that correctly predict a Nudix substrate or characterize a family is key to correctly annotate th
Externí odkaz:
https://doaj.org/article/2a955298ef584bbb83eaceaf80cb26e9
Autor:
Krisna C Duong-Ly, Hyun Nyun Woo, Christopher A Dunn, WenLian Xu, Andrej Babič, Maurice J Bessman, L Mario Amzel, Sandra B Gabelli
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64241 (2013)
The gene for a Nudix enzyme (SP_1669) was found to code for a UDP-X diphosphatase. The SP_1669 gene is localized among genes encoding proteins that participate in cell division in Streptococcus pneumoniae. One of these genes, MurF, encodes an enzyme
Externí odkaz:
https://doaj.org/article/b687255e82034ddba3d3e7e239bce26c
Autor:
Yang Xu, Agostinho Gomes Rocha, Shannon Chilewski, Krisna C. Duong‐Ly, Kun Yang, Jonathan Haulenbeek
Publikováno v:
Bioanalytical Aspects in Biological Therapeutics. :209-238
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::537b1f2f8114708c3a14ea946f0611e4
https://doi.org/10.1002/9781119523246.ch9
https://doi.org/10.1002/9781119523246.ch9
Autor:
Krisna C. Duong-Ly, Karthik Devarajan, Shuguang Liang, Kurumi Y. Horiuchi, Yuren Wang, Haiching Ma, Jeffrey R. Peterson
Publikováno v:
Cell Reports, Vol 14, Iss 4, Pp 772-781 (2016)
Small-molecule kinase inhibitors have typically been designed to inhibit wild-type kinases rather than the mutant forms that frequently arise in diseases such as cancer. Mutations can have serious clinical implications by increasing kinase catalytic
Externí odkaz:
https://doaj.org/article/ca7c0f68efed435f87f925bc9af95cd9
Autor:
Sandra B. Gabelli, Jesse B. Yoder, Silvia A. Pineiro, Andrew Schoeffield, Mario A. Pizarro Dupuy, Lakshmi Srinivasan, Akunna M. Iheanacho, Allister Suarez, Mario Amzel, P. Aitana Azurmendi, Krisna C. Duong-Ly
Publikováno v:
Biophysical Journal. 120:306a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b82c31525f5b5ca1aaf29e5efc95422
https://doi.org/10.1016/j.bpj.2020.11.1946
https://doi.org/10.1016/j.bpj.2020.11.1946
Autor:
Joy M. Cote, Krisna C. Duong-Ly, Jeffrey R. Peterson, Matthew C. Johnson, Glenn F. Rall, Jonathan Soboloff, Yin-Ming Kuo, Andrew J. Andrews, Justin M. Kollman
T cell-mediated adaptive immunity requires naïve, unstimulated T cells to transition from a quiescent metabolic state into a highly proliferative state upon T cell receptor engagement. This complex process depends on transcriptional changes mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835c54855aad04b3cf79c972b4908296
https://europepmc.org/articles/PMC6140318/
https://europepmc.org/articles/PMC6140318/
Publikováno v:
Biopolymers. 104:405-411
While crystal and NMR structures exist of the influenza A M2 protein, there is disagreement between models. Depending on the requirements of the technique employed, M2 has been studied in a range of membrane mimetics including detergent micelles and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4aed595ffc6f509865beacc5db7a0e
https://doi.org/10.1002/bip.22617
https://doi.org/10.1002/bip.22617
Autor:
Peng He, Ronald M. Levy, R. S. K. Vijayan, Krisna C. Duong-Ly, Jeffrey R. Peterson, Vivek Modi, Roland L. Dunbrack, Haiching Ma
Publikováno v:
Journal of Medicinal Chemistry
Structural coverage of the human kinome has been steadily increasing over time. The structures provide valuable insights into the molecular basis of kinase function and also provide a foundation for understanding the mechanisms of kinase inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08746f84973d02d584b0f9d4bb7355e
https://doi.org/10.1021/jm501603h
https://doi.org/10.1021/jm501603h
Autor:
Justin M. Kollman, Peter Michener, Matthew C. Johnson, Yin-Ming Kuo, Anika L. Burrell, Jeffrey R. Peterson, Andrew J. Andrews, Krisna C. Duong-Ly, Sajitha Anthony
Several metabolic enzymes undergo reversible polymerization into macromolecular assemblies. The function of these assemblies is often unclear but in some cases they regulate enzyme activity and metabolic homeostasis. The guanine nucleotide biosynthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17819870bf5114db25d67b37f47c9c1b
https://doi.org/10.1101/152173
https://doi.org/10.1101/152173
Autor:
Jeffrey R. Peterson, Peter Michener, Anika L. Burrell, Andrew J. Andrews, Sajitha Anthony, Jacqueline C. Simonet, Justin M. Kollman, Matthew C. Johnson, Yin-Ming Kuo, Krisna C. Duong-Ly
Publikováno v:
Molecular Biology of the Cell
The metabolic enzyme IMPDH assembles into octamers that can polymerize and form micron-scale structures in cells. Octamers can adopt active, expanded or inactive, compressed conformations driven by allosteric nucleotide and substrate binding. Both fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42407cbb68b24dbaf9c870c815b6fde5
https://pubmed.ncbi.nlm.nih.gov/28794265
https://pubmed.ncbi.nlm.nih.gov/28794265