Výsledky vyhledávání - "Krishnath M. Jayatilleke"

Akademický článek

Autor: Krishnath M. Jayatilleke, Mark D. Hulett

Publikováno v: Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-25 (2020)

Abstract Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, whilst liberating growth factors and cytokines bound to hep

Externí odkaz: https://doaj.org/article/40c9c074652d4073a0d58c5948501b73

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Supplementary Figure Legend from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Autor: Belinda S. Parker, Andreas Möller, Daniel M. Andrews, Paul J. Hertzog, Robin L. Anderson, Weisan Chen, Christina S. Wong, Peter Lock, Edwin D. Hawkins, Erin C. Lucas, Bradley N. Bidwell, Kun Xiao, Krishnath M. Jayatilleke, Clare Y. Slaney, Nikola Baschuk, Jai Rautela

Supplementary Figure Legend from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb9a19b9f3fa6271368bbbcc7452cfd
https://doi.org/10.1158/2326-6066.22537147

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Supplementary Figure 2 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

IL-2 stimulated NK cells derived from Ifnar1-/- or WT mice have comparable cytotoxicity against syngeneic breast tumor lines.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a3b20fa90e76663c1ecdd44fe7fcac
https://doi.org/10.1158/2326-6066.22537156

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Supplementary Figure 3 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Immune suppressor cell and T lymphocyte accumulation in the peripheral blood of WT and Ifnar1-/- mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b118c1caee30dc77cbae64b820652dc3
https://doi.org/10.1158/2326-6066.22537153.v1

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Data from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Metastatic progression is the major cause of breast cancer–related mortality. By examining multiple syngeneic preclinical breast cancer models in mice lacking a functional type-I interferon receptor (Ifnar1−/− mice), we show that host-derived t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf11cf72a9eab0bfb7ca92c702ec9684
https://doi.org/10.1158/2326-6066.c.6548332.v1

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Supplementary Figure 4 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Anti-proliferative effects and production of type-I IFN by balb/c syngeneic breast tumor cell lines.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9489ba7d23381a9d40109a90b7371d
https://doi.org/10.1158/2326-6066.22537150.v1

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Supplementary Figure 1 from Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Loss of hematopoietic Ifnar1 reduces metastasis-free survival in the 4T1.2 model.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057319000b60f587be9bb3fa7f764392
https://doi.org/10.1158/2326-6066.22537159

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Heparanase and the hallmarks of cancer

Autor: Mark D. Hulett, Krishnath M. Jayatilleke

Publikováno v: Journal of Translational Medicine
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-25 (2020)

Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, whilst liberating growth factors and cytokines bound to heparan sulp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc605bf5a518ac1b7a85953a1016d0b7
https://doi.org/10.1186/s12967-020-02624-1

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PO-220 Defining the role of heparanase in breast cancer progression using the PyMT-MMTV mouse model

Autor: Krishnath M. Jayatilleke, Hendrika M. Duivenvoorden, Mark D. Hulett, Belinda S. Parker

Publikováno v: ESMO Open. 3:A313

Introduction Heparanase (HPSE) is a beta-d-endoglucuronidase and the only mammalian enzyme that cleaves heparan sulphate (HS), a major structural and regulatory component of the extracellular matrix (ECM) and the vascular basement membrane (BM). The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ef8c3f63836b147b98f36c6cc52f6c9
https://doi.org/10.1136/esmoopen-2018-eacr25.738

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S-20

Autor: Jai Rautela, Paul John Hertzog, Krishnath M. Jayatilleke, Nikola Baschuk, Belinda S. Parker

Publikováno v: Cytokine. 70:25

It has been well described that the initiation and progression of some cancers is tightly controlled by tumour immunosurveillance. Our recent findings suggest that in breast cancer, the balance of pro-tumour and anti-tumour immune responses is critic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8054c875467938b40405af525cc80852
https://doi.org/10.1016/j.cyto.2014.07.240

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