Cross-Comparison of Inflammatory Skin Disease Transcriptomics Identifies PTEN as a Pathogenic Disease Classifier in Cutaneous Lupus Erythematosus.

Autor: Aevermann BD; J. Craig Venter Institute, La Jolla, California, USA; Chan Zuckerberg Initiative, Redwood City, California, USA., Di Domizio J; Department of Dermatology, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland., Olah P; Department of Dermatology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Saidoune F; Department of Dermatology, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland., Armstrong JM; Galderma, Lausanne, Switzerland., Bachelez H; Department of Dermatology, Paris Diderot University, Paris, France., Barker J; St John's Institute of Dermatology, Faculty of Life Sciences & Medicine, Kings College London, London, United Kingdom., Haniffa M; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle, United Kingdom., Julia V; Galderma, Lausanne, Switzerland., Juul K; LEO Pharma A/S, Ballerup, Denmark., Krishnaswamy JK; Galderma, Lausanne, Switzerland., Litman T; LEO Pharma A/S, Ballerup, Denmark., Parsons I; Celgene International Sarl, Boudry, Switzerland., Sarin KY; Department of Dermatology, Stanford University Medical Center, Palo Alto, California, USA., Schmuth M; Department of Dermatology, Venereology and Allergy, Medical University Innsbruck, Innsbruck, Austria., Sierra M; LEO Pharma A/S, Ballerup, Denmark., Simpson M; Department of Genomic Medicine, King's College London, London, United Kingdom., Homey B; Department of Dermatology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Griffiths CEM; Section of Dermatology, Department of Medicine, University of Manchester, Manchester, United Kingdom., Scheuermann RH; J. Craig Venter Institute, La Jolla, California, USA; Department of Pathology, University of California San Diego School of Medicine, La Jolla, California, USA; La Jolla Institute for Immunology, La Jolla, California, USA., Gilliet M; Department of Dermatology, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland. Electronic address: michel.gilliet@chuv.ch.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2024 Feb; Vol. 144 (2), pp. 252-262.e4. Date of Electronic Publication: 2023 Aug 19.

Modulation of Neuroimmune and Epithelial Dysregulation in Patients With Moderate to Severe Prurigo Nodularis Treated With Nemolizumab.

Autor: Deng J; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Liao V; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Parthasarathy V; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Cornman HL; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Kambala A; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Kwatra MM; Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina., Ständer S; Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany., Piketty C; Galderma SA, Lausanne, Switzerland., Chaskar P; Galderma SA, Lausanne, Switzerland., Krishnaswamy JK; Galderma SA, Lausanne, Switzerland., Julia V; Galderma SA, Lausanne, Switzerland., Kwatra SG; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Publikováno v: JAMA dermatology [JAMA Dermatol] 2023 Sep 01; Vol. 159 (9), pp. 977-985.

Allergic sensitization impairs lung resident memory CD8 T-cell response and virus clearance.

Autor: Agrawal K; Translational Science & Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Ong LC; Department of Microbiology and Immunology, Gothenburg University, Gothenburg, Sweden., Monkley S; Translational Science & Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Thörn K; Translational Science & Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Israelsson E; Translational Science & Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Baturcam E; Early Clinical Research, R&I, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Rist C; Translational Science & Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Schön K; Department of Microbiology and Immunology, Gothenburg University, Gothenburg, Sweden., Blake S; Translational Science & Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Magnusson B; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Cartwright J; Respiratory & Immunology (IA) Safety, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Mitra S; Inserm UMR1277 CNRS UMR9020 - CANTHER, Institut pour la Recherche sur le Cancer de Lille, Lille, France., Ravi A; the Department of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Zounemat-Kermani N; the Data Science Institute, Imperial College London, London, United Kingdom., Krishnaswamy JK; Translational Science & Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Lycke NY; Department of Microbiology and Immunology, Gothenburg University, Gothenburg, Sweden., Gehrmann U; Translational Science & Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Mattsson J; Translational Science & Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. Electronic address: Johan.mattsson@astrazeneca.com.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2022 Dec; Vol. 150 (6), pp. 1415-1426.e9. Date of Electronic Publication: 2022 Jul 30.

Transcriptomic characterization of prurigo nodularis and the therapeutic response to nemolizumab.

Autor: Tsoi LC; Department of Dermatology, University of Michigan, Ann Arbor, Mich; Department of Biostatistics, University of Michigan, Ann Arbor, Mich; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Mich., Hacini-Rachinel F; Galderma, La Tour-De-Peilz, Switzerland., Fogel P; Galderma, La Tour-De-Peilz, Switzerland., Rousseau F; Galderma, La Tour-De-Peilz, Switzerland., Xing X; Department of Dermatology, University of Michigan, Ann Arbor, Mich., Patrick MT; Department of Dermatology, University of Michigan, Ann Arbor, Mich., Billi AC; Department of Dermatology, University of Michigan, Ann Arbor, Mich., Berthier CC; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, Mich., Kahlenberg JM; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Mich; Taubman Medical Research Institute, University of Michigan Medical School, Ann Arbor, Mich., Lazzari A; Galderma, La Tour-De-Peilz, Switzerland., Wiegmann H; Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany., Ständer S; Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany., Piketty C; Galderma, La Tour-De-Peilz, Switzerland., Julia V; Galderma, La Tour-De-Peilz, Switzerland., Krishnaswamy JK; Galderma, La Tour-De-Peilz, Switzerland., Gudjonsson JE; Department of Dermatology, University of Michigan, Ann Arbor, Mich; Taubman Medical Research Institute, University of Michigan Medical School, Ann Arbor, Mich. Electronic address: johanng@umich.edu.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2022 Apr; Vol. 149 (4), pp. 1329-1339. Date of Electronic Publication: 2021 Nov 29.

Transcriptomics Analysis Indicates Trifarotene Reverses Acne-Related Gene Expression Changes.

Autor: Dreno B; Dermatology Department, CHU Nantes, Nantes, France., Chavda R; Galderma R&D, La Tour-de-Peilz, Switzerland., Julia V; Galderma R&D, La Tour-de-Peilz, Switzerland., Khammari A; Dermatology Department, CHU Nantes, Nantes, France., Blanchet-Réthoré S; Syneos Health, Translational Sciences, Sophia Antipolis, France., Krishnaswamy JK; Galderma R&D, La Tour-de-Peilz, Switzerland.

Publikováno v: Frontiers in medicine [Front Med (Lausanne)] 2021 Oct 22; Vol. 8, pp. 745822. Date of Electronic Publication: 2021 Oct 22 (Print Publication: 2021).