Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Krishnangsu Pradhan"'
Autor:
Rajsekhar Roy, Krishnangsu Pradhan, Juhee Khan, Gaurav Das, Nabanita Mukherjee, Durba Das, Surajit Ghosh
Publikováno v:
ACS Omega, Vol 5, Iss 30, Pp 18628-18641 (2020)
Externí odkaz:
https://doaj.org/article/b4fb3f706f2c41b29260c40058fe6d18
Autor:
Krishnangsu Pradhan, Gaurav Das, Chirantan Kar, Nabanita Mukherjee, Juhee Khan, Tanushree Mahata, Surajit Barman, Surajit Ghosh
Publikováno v:
ACS Omega, Vol 5, Iss 30, Pp 18958-18967 (2020)
Externí odkaz:
https://doaj.org/article/cff2a1a163934a328faeaba71c8e6b0e
Autor:
Rajsekhar Roy, Juhee Khan, Krishnangsu Pradhan, Prasunpriya Nayak, Ankan Sarkar, Subhadra Nandi, Surojit Ghosh, Heera Ram, Surajit Ghosh
Publikováno v:
ACS Chemical Neuroscience. 14:246-260
Amyloid-β 42(Aβ42), an enzymatically cleaved (1-42 amino acid long) toxic peptide remnant, has long been reported to play the key role in Alzheimer's disease (AD). Aβ42 also plays the key role in the onset of other AD-related factors including hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d4150f68b02ad29fd4068d28d81226
https://doi.org/10.1021/acschemneuro.2c00549
https://doi.org/10.1021/acschemneuro.2c00549
Autor:
Nabanita Mukherjee, Krishnangsu Pradhan, Surajit Barman, Tanushree Mahata, Gaurav Das, Chirantan Kar, Juhee Khan, Surajit Ghosh
Publikováno v:
ACS Omega, Vol 5, Iss 30, Pp 18958-18967 (2020)
ACS Omega
ACS Omega
Alzheimer’s disease (AD) exhibits a multitude of syndromes which add up to its complex nature. In AD, amyloid plaques are deposited along with abnormal accumulation of transition-metal ions. These transition-metal ions are redox-active and help to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e380de9198613f3a6777cfa75beeff
https://doaj.org/article/cff2a1a163934a328faeaba71c8e6b0e
https://doaj.org/article/cff2a1a163934a328faeaba71c8e6b0e
Autor:
Abhijit Saha, Surajit Ghosh, Rathnam Mallesh, Juhee Khan, Prasenjit Mondal, Gaurav Das, Krishnangsu Pradhan, Batakrishna Jana
Publikováno v:
ACS Chemical Neuroscience. 10:2609-2620
Amyloid-beta (Aβ) peptide misfolds into fibrillary aggregates (β-sheet) and is deposited as amyloid plaques in the cellular environment, which severely damages intraneuronal connections leading to Alzheimer's disease (AD) pathogenesis. Furthermore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1f02ad17bf9c175dd7b2e0f1b47a8c
https://doi.org/10.1021/acschemneuro.9b00115
https://doi.org/10.1021/acschemneuro.9b00115
Autor:
Surajit Barman, Prasenjit Mondal, Surajit Ghosh, Chirantan Kar, Gaurav Das, Batakrishna Jana, Krishnangsu Pradhan, Debmalya Bhunia, Abhijit Saha
Publikováno v:
Chemical Communications. 55:2356-2359
An indole-rich tripodal microtubule inhibitor is designed, which binds at the DCVJ site of tubulin and inhibits its polymerization. It causes apoptotic death of cancer cells without affecting normal cells and inhibits the growth of tumors. Finally, S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2b5723d6574ca9069489766b196755
https://doi.org/10.1039/c9cc00074g
https://doi.org/10.1039/c9cc00074g
Autor:
Surajit Ghosh, Durba Das, Juhee Khan, Gaurav Das, Nabanita Mukherjee, Rajsekhar Roy, Krishnangsu Pradhan
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 30, Pp 18628-18641 (2020)
ACS Omega, Vol 5, Iss 30, Pp 18628-18641 (2020)
In Alzheimer's disease (AD), insoluble Aβ42 peptide fragments self-aggregate and form oligomers and fibrils in the brain, causing neurotoxicity. Further, the presence of redox-active metal ions such as Cu2+ enhances the aggregation process through c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783f71661875cbb2c90c5cf00c4a8e29
https://pubmed.ncbi.nlm.nih.gov/32775865
https://pubmed.ncbi.nlm.nih.gov/32775865
Autor:
Surajit Ghosh, Anindyasundar Adak, Surajit Barman, Varsha Gupta, Juhee Khan, Krishnangsu Pradhan, Gaurav Das
Publikováno v:
ACS Chemical Neuroscience. 10:1535-1543
Brain damage is associated with spatial imbalance of cholinergic system, which makes severe impact in recovery of damaged neurons of brain. Therefore, maintenance of cholinergic system is extremely important. Here, we fabricated an injectable hydroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8baf1fb4c454c64a03275b3c199b2df
https://doi.org/10.1021/acschemneuro.8b00514
https://doi.org/10.1021/acschemneuro.8b00514
Autor:
Prasenjit Mondal, Surajit Barman, Juhee Khan, Gaurav Das, Krishnangsu Pradhan, Varsha Gupta, Surajit Ghosh
Publikováno v:
ACS Chemical Neuroscience. 10:1355-1368
Development of potential therapeutics for Alzheimer's disease (AD) requires a multifaceted strategy considering the high levels of complexity of the human brain and its mode of function. Here, we adopted an advanced strategy targeting two key patholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae59583215f04b13c551562d14be8882
https://doi.org/10.1021/acschemneuro.8b00427
https://doi.org/10.1021/acschemneuro.8b00427
Publikováno v:
ACS Chemical Neuroscience. 9:2929-2940
Aβ peptide and hyper-phosphorylated microtubule associated protein (Tau) aggregation causes severe damage to both the neuron membrane and key signal processing microfilament (microtubule) in Alzheimer's disease (AD) brains. To date, the key challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40337312671380dcb3320e47122d4a5
https://doi.org/10.1021/acschemneuro.8b00071
https://doi.org/10.1021/acschemneuro.8b00071