Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Krishnamoorthi Sumaiya"'
Autor:
Krishnamoorthi Sumaiya, Charles Solomon Akino Mercy, Gangatharan Muralitharan, Abdurahman Hajinur Hirad, Abdullah A. Alarfaj, Kalimuthusamy Natarajaseenivasan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
The search for valuable early diagnostic markers for leptospirosis is ongoing. The aim of the present study was to evaluate the diagnostic value of macrophage migration inhibitory factor (MIF) for leptospirosis. MIF is an immunoregulatory cytokine se
Externí odkaz:
https://doaj.org/article/2cd0bd52e60b4d91a786b5cc843ef99b
Autor:
Krishnamoorthi Sumaiya, Thiruvelselvan Ponnusamy, Kalimuthusamy Natarajaseenivasan, Santhanam Shanmughapriya
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 50 (2022)
The aberrant increase in cardio-metabolic diseases over the past couple of decades has drawn researchers’ attention to explore and unveil the novel mechanisms implicated in cardiometabolic diseases. Recent evidence disclosed that the derangement of
Externí odkaz:
https://doaj.org/article/fcbcec44a24e41939810bc666a271a67
Autor:
Charles Solomon Akino Mercy, Natarajaseenivasan Suriya Muthukumaran, Prema Velusamy, Palanisamy Bothammal, Krishnamoorthi Sumaiya, Perumal Saranya, Dianne Langford, Santhanam Shanmughapriya, Kalimuthusamy Natarajaseenivasan
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
ABSTRACT Leptospirosis remains a significant human health issue due to its systemic complications. Therefore, biomarkers that are more effective are urgently needed for the early diagnosis of leptospirosis. MicroRNAs (miRNAs) are evolutionarily conse
Externí odkaz:
https://doaj.org/article/9234263d42664b83a20c4264019fc160
Publikováno v:
Microbial pathogenesis. 173
To develop the macrophage migration inhibitory factor (MIF) directed therapeutic approach for the treatment of leptospirosis, we identified potential MIF inhibitors by screening 10 essential tautomerase inhibition classes of chemical compounds and 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c249c690b91751b11f2f1da34807e91
https://pubmed.ncbi.nlm.nih.gov/36150555
https://pubmed.ncbi.nlm.nih.gov/36150555
Autor:
Dianne Langford, Santhanam Shanmughapriya, Kalimuthusamy Natarajaseenivasan, Krishnamoorthi Sumaiya
Publikováno v:
Pharmacologytherapeutics. 233
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a functionally polymorphic genetic locus. MIF was initially recognized as a cytokine generated by activated T cells, but in recent days it has been identified a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c415027cd514c24ba5b7616893fea1d4
https://pubmed.ncbi.nlm.nih.gov/34673115
https://pubmed.ncbi.nlm.nih.gov/34673115
Publikováno v:
Microbial Pathogenesis. 164:105445
The biological mechanisms that are associated with the severity of leptospirosis are far from complete. The aim of the present study was to investigate whether the macrophage migration inhibitory factor (MIF) gene promoter polymorphisms determine sus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8637f140c0f08be407312b05fecb4eb
https://doi.org/10.1016/j.micpath.2022.105445
https://doi.org/10.1016/j.micpath.2022.105445
Autor:
Kalimuthusamy Natarajaseenivasan, Santhanam Shanmughapriya, Perumal Saranya, Charles Solomon Akino Mercy, Natarajaseenivasan Suriya Muthukumaran, Prema Velusamy, Krishnamoorthi Sumaiya, Palanisamy Bothammal, Dianne Langford
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
mSphere, Vol 5, Iss 4, p e00409-20 (2020)
mSphere
mSphere, Vol 5, Iss 4, p e00409-20 (2020)
mSphere
Here, we used miRNAs that are differentially regulated by the LPS/TLR2 immune axis to devise a miRNA-based diagnosis for leptospirosis. The study established the role of the circulating stable miRNAs (miR-21-5p, miR-144-3p, and miR-let-7b-5p) as an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990a1e80311839845e9ad4ef0ff8e0f8
https://journals.asm.org/doi/10.1128/mSphere.00409-20
https://journals.asm.org/doi/10.1128/mSphere.00409-20
Autor:
Kalimuthusamy Natarajaseenivasan, Charles Solomon Akino Mercy, Krishnamoorthi Sumaiya, Perumal Saranya, Muthu Prasad, Palanisamy Bothammal, Gangatharan Muralitharan
Publikováno v:
Microbial pathogenesis. 149
Leptospirosis is considered as a neglected tropical disease which is caused by pathogenic Leptospira spp. The precise mechanisms of leptospirosis pathogenesis are unclear and hence, the progress in development of treatment modalities has been dismal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56bc80b436dd251daa02e44a5566b79
https://pubmed.ncbi.nlm.nih.gov/32758519
https://pubmed.ncbi.nlm.nih.gov/32758519
Autor:
Perumal Saranya, Shanmugam Vanithamani, Naif Abdullah Al-Dhabi, Gangatharan Muralitharan, Charles Solomon Akino Mercy, Krishnamoorthi Sumaiya, Paluru Vijayachari, Karuppiah Ponmurugan, Muthu Prasad, Palanisamy Bothammal, Kalimuthusamy Natarajaseenivasan, Ashutosh Verma, Murugesan Kanagavel
Publikováno v:
Microbial Pathogenesis. 152:104738
Lipopolysaccharide (LPS) is the major surface antigen of Leptospira. In this study, the genes involved in the LPS biosynthesis were analyzed and compared by bioinformatics tools. Also, the chemical composition analysis of leptospiral lipopolysacchari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d280db9a573c6cbc7b16788d03291d9
https://doi.org/10.1016/j.micpath.2021.104738
https://doi.org/10.1016/j.micpath.2021.104738
Autor:
Palanisamy Bothammal, Veerapandian Raja, Charles Solomon Akino Mercy, Perumal Saranya, Krishnamoorthi Sumaiya, Muthu Prasad, Kalimuthusamy Natarajaseenivasan
Publikováno v:
Journal of microbiological methods. 156
Leptospirosis is a widespread zoonotic disease and lacks in efficient diagnostic tools. In the present study, a nanogold based dot blot immunoassay was developed and evaluated for the detection of leptospirosis in human urine samples. This method was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09cbf9326247505e5e8832e9eb72274
https://pubmed.ncbi.nlm.nih.gov/30502367
https://pubmed.ncbi.nlm.nih.gov/30502367