Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Krishnakumar, Vaithilingam"'
Autor:
Krishnakumar, Vaithilingam1 (AUTHOR), Munisamy, Suthandhira2 (AUTHOR), Pandiyan, Rajesh3 (AUTHOR), Velu, Rajesh Kannan1 (AUTHOR) uvrajesh@gmail.com, Periasamy, Panneerselvam4 (AUTHOR)
Publikováno v:
BLDE University Journal of Health Sciences. Jan-Jun2024, Vol. 9 Issue 1, p46-49. 4p.
Autor:
Chandru Gajendran, Subramanyam Janardhan Tantry, Naveen Sadhu M, Zainuddin Mohammed, Purushottam Dewang, Mahanandeesha Hallur, Sreekala Nair, Krishnakumar Vaithilingam, Basavaprabhu Nagayya, Sridharan Rajagopal, Dhanalakshmi Sivanandhan
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0279063 (2023)
Dually targeting the epigenetic proteins lysine specific demethylase 1 (LSD1) and histone deacetylases (HDACs) that play a key role in cancer cells by modulating gene repressor complexes including CoREST will have a profound effect in inhibiting tumo
Externí odkaz:
https://doaj.org/article/f5b9a894f21344f3b3a771a2cac2103a
Autor:
Panneerselvam Periasamy, Shajahan Ansar, Vajiravelu Suganthi, Sasikala Gunasekaran, Krishnakumar Vaithilingam, Velu Rajesh Kannan
Publikováno v:
International Journal of Life Science and Pharma Research.
The COVID-19 pandemic has forced the public health authorities to impose a lockdown as an epidemiological containment strategy. Due to COVID-19, the world is facing an unprecedented challenge that has changed people's lifestyles. This study aimed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67053a1ac698eb94c3be67805722e8d8
https://doi.org/10.22376/ijpbs/lpr.2022.12.6.l47-58
https://doi.org/10.22376/ijpbs/lpr.2022.12.6.l47-58
Akademický článek
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Publikováno v:
Archives of Medicine & Health Sciences; Jan-Jun2023, Vol. 11 Issue 1, p32-36, 5p
Publikováno v:
Methods for Fragments Screening Using Surface Plasmon Resonance ISBN: 9789811615351
In this chapter, we focus on the ideal strategy to optimize and validate amine coupling for SPR studies. In particular, we provide an in-depth description of each and every component required to establish validation before the screening of fragments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00e2a33f2c74fc20f177c42c8576c223
https://doi.org/10.1007/978-981-16-1536-8_9
https://doi.org/10.1007/978-981-16-1536-8_9
Publikováno v:
Methods for Fragments Screening Using Surface Plasmon Resonance ISBN: 9789811615351
One of the hurdles seen with some proteins is that the analyte binding site has lysine rich residues, which impede biophysical interaction between the ligand and analyte. To overcome this snag, non-covalent capture method was developed that has the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08c804db632961de4a1dc482aa07b049
https://doi.org/10.1007/978-981-16-1536-8_10
https://doi.org/10.1007/978-981-16-1536-8_10
Publikováno v:
Methods for Fragments Screening Using Surface Plasmon Resonance ISBN: 9789811615351
Preparation of SPR sensor is an important part, prior to assay and screening. Biosensors are highly fragile and form the basic component of the SPR instrument. Improper sensitization or activation of biosensors can lead to nonuniform ligation of liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8ebb4c2a2fbaf0c35f6a7a7574ed41f
https://doi.org/10.1007/978-981-16-1536-8_8
https://doi.org/10.1007/978-981-16-1536-8_8
Autor:
Mohd Zainuddin, Chandru Gajendran, Dhanalakshmi Sivanandhan, Kannan Murugan, Srinatha Chickamunivenkatappa, Subramanyam J. Tantry, Sridharan Rajagopal, M Naveen Sadhu, Krishnakumar Vaithilingam, Purushottam M. Dewang, Sreekala Nair
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 34:127763
Lysine specific demethylase 1 (LSD1) and HDAC6 are epigenetic proteins associated with several diseases, including cancer and combined inhibition of these proteins could be highly beneficial in treating some cancers such as AML, MM and solid tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b4cd987cce9b130eb5b2aa0d162fc8
https://doi.org/10.1016/j.bmcl.2020.127763
https://doi.org/10.1016/j.bmcl.2020.127763
Akademický článek
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