Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Krishnakumar, Kizhatil"'
Autor:
Revathi Balasubramanian, Krishnakumar Kizhatil, Taibo Li, Nicholas Tolman, Aakriti Bhandari, Graham Clark, Violet Bupp-Chickering, Ruth A Kelly, Sally Zhou, John Peregrin, Marina Simón, Christa Montgomery, W Daniel Stamer, Jiang Qian, Simon WM John
Publikováno v:
eLife, Vol 13 (2024)
Schlemm’s canal (SC) is central in intraocular pressure regulation but requires much characterization. It has distinct inner and outer walls, each composed of Schlemm’s canal endothelial cells (SECs) with different morphologies and functions. Rec
Externí odkaz:
https://doaj.org/article/51d832f1ed604c4ab2be5f5c1d392221
Autor:
K. Saidas Nair, Chitrangda Srivastava, Robert V. Brown, Swanand Koli, Hélène Choquet, Hong Soon Kang, Yien-Ming Kuo, Sara A. Grimm, Caleb Sutherland, Alexandra Badea, G. Allan Johnson, Yin Zhao, Jie Yin, Kyoko Okamoto, Graham Clark, Terete Borrás, Gulab Zode, Krishnakumar Kizhatil, Subhabrata Chakrabarti, Simon W. M. John, Eric Jorgenson, Anton M. Jetten
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Dysfunction of the trabecular meshwork (TM) is the chief cause of elevated intraocular pressure, the major risk factor of glaucoma. Here, the authors identify the transcription factor, GLIS1, as a critical regulator of TM maintenance and intraocular
Externí odkaz:
https://doaj.org/article/1d13ccf102314720a834e165f6b1a62d
Autor:
Pete A. Williams, Catherine E. Braine, Krishnakumar Kizhatil, Nicole E. Foxworth, Nicholas G. Tolman, Jeffrey M. Harder, Rebecca A. Scott, Gregory L. Sousa, Alyssa Panitch, Gareth R. Howell, Simon W. M. John
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-23 (2019)
Abstract Background Glaucoma is characterized by the progressive dysfunction and loss of retinal ganglion cells. Recent work in animal models suggests that a critical neuroinflammatory event damages retinal ganglion cell axons in the optic nerve head
Externí odkaz:
https://doaj.org/article/1d88fd54288e4ead90e9c80f9e2ea71f
Autor:
Nicholas G. Tolman, Revathi Balasubramanian, Danilo G. Macalinao, Alison L. Kearney, Katharine H. MacNicoll, Christa L. Montgomery, Wilhelmine N. de Vries, Ian J. Jackson, Sally H. Cross, Krishnakumar Kizhatil, K. Saidas Nair, Simon W. M. John
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Variants in the LIM homeobox transcription factor 1-beta (LMX1B) gene predispose individuals to elevated intraocular pressure (IOP), a key risk factor for glaucoma. However, the effect of LMX1B mutations varies widely between individuals. To better u
Externí odkaz:
https://doaj.org/article/c6b3c570e59e4dcfbb215df5e8ffb694
Publikováno v:
PLoS Biology, Vol 12, Iss 7, p e1001912 (2014)
Schlemm's canal (SC) plays central roles in ocular physiology. These roles depend on the molecular phenotypes of SC endothelial cells (SECs). Both the specific phenotype of SECs and development of SC remain poorly defined. To allow a modern and exten
Externí odkaz:
https://doaj.org/article/cc3472acad4944769befa94b4ac6df3c
Autor:
Krishnakumar Kizhatil, Danilo G. Macalinao, Sally H. Cross, Wilhelmine N. de Vries, Ian J. Jackson, K. Saidas Nair, Nicholas G. Tolman, Alison L. Kearney, Christa L. Montgomery, Katharine H. MacNicoll, Revathi Balasubramanian, Simon W. M. John
Publikováno v:
Tolman, NG, Balasubramanian, R, Macalinao, D G, Kearney, A L, MacNicoll, KH, Montgomery, C L, de Vries, WN, Jackson, I J, Cross, S, Kizhatil, K, Nair, KS & John, SWM 2021, ' Genetic background modifies vulnerability to glaucoma related phenotypes in Lmx1b mutant mice ', Disease Models and Mechanisms . https://doi.org/10.1242/dmm.046953
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Variants in the LIM homeobox transcription factor 1-beta (LMX1B) gene predispose individuals to elevated intraocular pressure (IOP), a key risk factor for glaucoma. However, the effect of LMX1B mutations varies widely between individuals. To better u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e75d0cad79578c4d4f4a32c26eefdf6
https://doi.org/10.1242/dmm.046953
https://doi.org/10.1242/dmm.046953
Autor:
Nicholas G, Tolman, Revathi, Balasubramanian, Danilo G, Macalinao, Alison L, Kearney, Katharine H, MacNicoll, Christa L, Montgomery, Wilhelmine N, de Vries, Ian J, Jackson, Sally H, Cross, Krishnakumar, Kizhatil, K Saidas, Nair, Simon W M, John
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Variants in the LIM homeobox transcription factor 1-beta (LMX1B) gene predispose individuals to elevated intraocular pressure (IOP), a key risk factor for glaucoma. However, the effect of LMX1B mutations varies widely between individuals. To better u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c342cda45eb1b5f9f6dc046d7c6df31d
https://pubmed.ncbi.nlm.nih.gov/33462143
https://pubmed.ncbi.nlm.nih.gov/33462143
Autor:
Colleen M. McDowell, Krishnakumar Kizhatil, Michael H. Elliott, Darryl R. Overby, Joseph van Batenburg-Sherwood, J. Cameron Millar, Markus H. Kuehn, Gulab Zode, Ted S. Acott, Michael G. Anderson, Sanjoy K. Bhattacharya, Jacques A. Bertrand, Terete Borras, Diane E. Bovenkamp, Lin Cheng, John Danias, Michael Lucio De Ieso, Yiqin Du, Jennifer A. Faralli, Rudolf Fuchshofer, Preethi S. Ganapathy, Haiyan Gong, Samuel Herberg, Humberto Hernandez, Peter Humphries, Simon W. M. John, Paul L. Kaufman, Kate E. Keller, Mary J. Kelley, Ruth A. Kelly, David Krizaj, Ajay Kumar, Brian C. Leonard, Raquel L. Lieberman, Paloma Liton, Yutao Liu, Katy C. Liu, Navita N. Lopez, Weiming Mao, Timur Mavlyutov, Fiona McDonnell, Gillian J. McLellan, Philip Mzyk, Andrews Nartey, Louis R. Pasquale, Gaurang C. Patel, Padmanabhan P. Pattabiraman, Donna M. Peters, Vijaykrishna Raghunathan, Ponugoti Vasantha Rao, Naga Rayana, Urmimala Raychaudhuri, Ester Reina-Torres, Ruiyi Ren, Douglas Rhee, Uttio Roy Chowdhury, John R. Samples, E. Griffen Samples, Najam Sharif, Joel S. Schuman, Val C. Sheffield, Cooper H. Stevenson, Avinash Soundararajan, Preeti Subramanian, Chenna Kesavulu Sugali, Yang Sun, Carol B. Toris, Karen Y. Torrejon, Amir Vahabikashi, Janice A. Vranka, Ting Wang, Colin E. Willoughby, Chen Xin, Hongmin Yun, Hao F. Zhang, Michael P. Fautsch, Ernst R. Tamm, Abbot F. Clark, C. Ross Ethier, W. Daniel Stamer
Publikováno v:
Investigative ophthalmology & visual science, vol 63, iss 2
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2366dca55a396f9cef10de74cc76d5
https://doi.org/10.1167/iovs.63.2.12
https://doi.org/10.1167/iovs.63.2.12
Autor:
Simone Finzi, Janey L. Wiggs, David A. Mackey, Terri L. Young, Shahrbanou Javadiyan, Owen M. Siggs, Stuart W. Tompson, Francesca Pasutto, Xiaorong Liu, Dimitar N. Azmanov, Simon W. M. John, Yasmin S. Bradfield, Alex W. Hewitt, Kristina N. Whisenhunt, Liang Feng, Tuncer Onay, Jamie E Craig, Benjamin R. Thomson, Luba Kalaydjieva, Jing Jin, Emmanuelle Souzeau, Tammy L. Yanovitch, Krishnakumar Kizhatil, Susan E. Quaggin, Christine A Tanna, Tomokazu Souma
Publikováno v:
Journal of Clinical Investigation. 127:4421-4436
Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm’s canal (SC) and the trabecular meshwork. We previously identified loss-of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c7287db8159566227b0569b3795f01
https://doi.org/10.1172/jci95545
https://doi.org/10.1172/jci95545
Autor:
Krishnakumar Kizhatil, Catherine E. Braine, Peter A. Williams, Gareth R. Howell, Jeffrey M. Harder, Alyssa Panitch, Rebecca A. Scott, Simon W. M. John, Nicole E. Foxworth, Nicholas G. Tolman, Gregory L. Sousa
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-23 (2019)
Molecular Neurodegeneration
Molecular neurodegeneration, vol 14, iss 1
Molecular Neurodegeneration
Molecular neurodegeneration, vol 14, iss 1
Background Glaucoma is characterized by the progressive dysfunction and loss of retinal ganglion cells. Recent work in animal models suggests that a critical neuroinflammatory event damages retinal ganglion cell axons in the optic nerve head during o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adfa6d4b756418fa217801a772b1cd8f
https://doi.org/10.1186/s13024-018-0303-3
https://doi.org/10.1186/s13024-018-0303-3