Zobrazeno 1 - 10
of 262
pro vyhledávání: '"Krishna V, Shenoy"'
Autor:
Darrel R. Deo, Francis R. Willett, Donald T. Avansino, Leigh R. Hochberg, Jaimie M. Henderson, Krishna V. Shenoy
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Brain-computer interfaces have so far focused largely on enabling the control of a single effector, for example a single computer cursor or robotic arm. Restoring multi-effector motion could unlock greater functionality for people with paral
Externí odkaz:
https://doaj.org/article/ea144ca300b044dc9e34c2c48bb20dca
Autor:
Pierre O. Boucher, Tian Wang, Laura Carceroni, Gary Kane, Krishna V. Shenoy, Chandramouli Chandrasekaran
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-28 (2023)
Abstract We used a dynamical systems perspective to understand decision-related neural activity, a fundamentally unresolved problem. This perspective posits that time-varying neural activity is described by a state equation with an initial condition
Externí odkaz:
https://doaj.org/article/b4e54ad170e44424b21e93990519f0f5
Autor:
Eric M. Trautmann, Daniel J. O’Shea, Xulu Sun, James H. Marshel, Ailey Crow, Brian Hsueh, Sam Vesuna, Lucas Cofer, Gergő Bohner, Will Allen, Isaac Kauvar, Sean Quirin, Matthew MacDougall, Yuzhi Chen, Matthew P. Whitmire, Charu Ramakrishnan, Maneesh Sahani, Eyal Seidemann, Stephen I. Ryu, Karl Deisseroth, Krishna V. Shenoy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Surface two-photon imaging of the brain cannot access somatic calcium signals of neurons from deep layers of the macaque cortex. Here, the authors present an implant and imaging system for chronic motion-stabilized two-photon imaging of dendritic cal
Externí odkaz:
https://doaj.org/article/862821d7098a4f46ba50d01c4f46809e
Autor:
Krishna V. Shenoy, Jonathan C. Kao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-5 (2021)
Neural recording technologies increasingly enable simultaneous measurement of neural activity from multiple brain areas. To gain insight into distributed neural computations, a commensurate advance in experimental and analytical methods is necessary.
Externí odkaz:
https://doaj.org/article/5afd9039053a46df8e05c3dc1a78e665
Autor:
Eric Kenji Lee, Hymavathy Balasubramanian, Alexandra Tsolias, Stephanie Udochukwu Anakwe, Maria Medalla, Krishna V Shenoy, Chandramouli Chandrasekaran
Publikováno v:
eLife, Vol 10 (2021)
Cortical circuits are thought to contain a large number of cell types that coordinate to produce behavior. Current in vivo methods rely on clustering of specified features of extracellular waveforms to identify putative cell types, but these capture
Externí odkaz:
https://doaj.org/article/ba9758c024dc40e9937e63f794062ac2
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Motor preparation processes guide movement. Here, by recording neural activity in monkeys reaching toward targets that can change location, the authors provide evidence that changing a prepared movement midway through completion reengages motor prepa
Externí odkaz:
https://doaj.org/article/1aca069c1bd941e9abf23727a56a98b3
Autor:
Megan Wang, Christéva Montanède, Chandramouli Chandrasekaran, Diogo Peixoto, Krishna V. Shenoy, John F. Kalaska
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
It is not clear to what degree activity in dorsal premotor cortex (PMd) reflects perceptual-deliberation versus action-selection aspects of decision-making. Here, the authors report that monkey PMd neurons do not express correlates of the perceptual
Externí odkaz:
https://doaj.org/article/d07284ba3ba5470abbcff49f295bd7a3
Publikováno v:
eLife, Vol 9 (2020)
A long-standing challenge in motor neuroscience is to understand the relationship between movement speed and accuracy, known as the speed-accuracy tradeoff. Here, we introduce a biomechanically realistic computational model of three-dimensional upper
Externí odkaz:
https://doaj.org/article/ce2c27ab3ff04acabd3f7f33540cf6ac
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108006- (2020)
Summary: In multiple cortical areas, including the motor cortex, neurons have similar firing rate statistics whether we observe or execute movements. These “congruent” neurons are hypothesized to support action understanding by participating in a
Externí odkaz:
https://doaj.org/article/694e58d40a2a4381a0eddfcb267020e6
Autor:
Daniel J. O’Shea, Paul Kalanithi, Emily A. Ferenczi, Brian Hsueh, Chandramouli Chandrasekaran, Werapong Goo, Ilka Diester, Charu Ramakrishnan, Matthew T. Kaufman, Stephen I. Ryu, Kristen W. Yeom, Karl Deisseroth, Krishna V. Shenoy
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-20 (2018)
Abstract Optogenetic tools have opened a rich experimental landscape for understanding neural function and disease. Here, we present the first validation of eight optogenetic constructs driven by recombinant adeno-associated virus (AAV) vectors and a
Externí odkaz:
https://doaj.org/article/06230dc486274d2584a529f403050899