Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Krishna Sriram"'
Autor:
Anna Di Nardo, Yu-Ling Chang, Shahrzad Alimohammadi, Kana Masuda-Kuroki, Zhenping Wang, Krishna Sriram, Paul A. Insel
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112453- (2023)
Summary: Activation and degranulation of mast cells (MCs) is an essential aspect of innate and adaptive immunity. Skin MCs, the most exposed to the external environment, are at risk of quickly degranulating with potentially severe consequences. Here,
Externí odkaz:
https://doaj.org/article/2487de5043c04ae09fb74e888e81e019
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Chronic decreases in the second messenger cyclic AMP (cAMP) occur in numerous settings, but how cells compensate for such decreases is unknown. We have used a unique system—murine dendritic cells (DCs) with a DC-selective depletion of the heterotri
Externí odkaz:
https://doaj.org/article/de126dcb359a4e1ba9d7a7370df0e1e0
Autor:
Krishna Sriram, Shu Z. Wiley, Kevin Moyung, Matthew W. Gorr, Cristina Salmerón, Jordin Marucut, Randall P. French, Andrew M. Lowy, Paul A. Insel
Publikováno v:
ACS Omega, Vol 4, Iss 16, Pp 17048-17059 (2019)
Externí odkaz:
https://doaj.org/article/803525e5e05a4f8092a8f081d92b3d70
Publikováno v:
Physiological Reports, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract Chronic hypoxia from diseases in the lung, such as pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease, can increase pulmonary vascular resistance, resulting in hypertrophy and dysfunction of the right ventr
Externí odkaz:
https://doaj.org/article/7ca406ab943c4b068e59585c4b3484dc
Publikováno v:
PLoS Biology, Vol 17, Iss 11, p e3000434 (2019)
G protein-coupled receptors (GPCRs) are the most widely targeted gene family for Food and Drug Administration (FDA)-approved drugs. To assess possible roles for GPCRs in cancer, we analyzed The Cancer Genome Atlas (TCGA) data for mRNA expression, mut
Externí odkaz:
https://doaj.org/article/f79a65962a274fcf817bacf7fa401bbb
Autor:
Paul A. Insel, Krishna Sriram, Shu Z. Wiley, Andrea Wilderman, Trishna Katakia, Thalia McCann, Hiroshi Yokouchi, Lingzhi Zhang, Ross Corriden, Dongling Liu, Michael E. Feigin, Randall P. French, Andrew M. Lowy, Fiona Murray
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
G protein-coupled receptors (GPCRs), the largest family of targets for approved drugs, are rarely targeted for cancer treatment, except for certain endocrine and hormone-responsive tumors. Limited knowledge regarding GPCR expression in cancer cells l
Externí odkaz:
https://doaj.org/article/28de7d53db774f9b8b4d7ba1fda6c2d8
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 3, p 559 (2019)
GPR68 (or ovarian cancer G protein-coupled receptor 1, OGR1) is a proton-sensing G-protein-coupled receptor (GPCR) that responds to extracellular acidity and regulates a variety of cellular functions. Acidosis is considered a defining hallmark of the
Externí odkaz:
https://doaj.org/article/7f70389594e542a1884171aaefa9f7d0
Automated Scoring (AS), the natural language processing task of scoring essays and speeches in an educational testing setting, is growing in popularity and being deployed across contexts from government examinations to companies providing language pr
Externí odkaz:
http://arxiv.org/abs/2111.08906
The number of videos being produced and consequently stored in databases for video streaming platforms has been increasing exponentially over time. This vast database should be easily index-able to find the requisite clip or video to match the given
Externí odkaz:
http://arxiv.org/abs/2012.15565
Autor:
Krishna, Sriram, Sinha, Nishant
The established way of interfacing with most computer systems is a mouse and keyboard. Hand gestures are an intuitive and effective touchless way to interact with computer systems. However, hand gesture based systems have seen low adoption among end-
Externí odkaz:
http://arxiv.org/abs/2010.13197