Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Krishna Rajarathnam"'
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101858- (2020)
Summary: Chemokines are unusual class-A G protein-coupled receptor agonists because of their large size (∼10 kDa) and binding at two distinct receptor sites: N-terminal domain (Site-I, unique to chemokines) and a groove defined by extracellular loo
Externí odkaz:
https://doaj.org/article/ac52d37cf4c34afe9afe9eae4cce3f78
Autor:
Krishna Rajarathnam, Umesh R. Desai
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Proteoglycans (PGs), present in diverse environments, such as the cell membrane surface, extracellular milieu, and intracellular granules, are fundamental to life. Sulfated glycosaminoglycans (GAGs) are covalently attached to the core protein of prot
Externí odkaz:
https://doaj.org/article/35e3452943094604968abacf81b607cb
Autor:
Valerie J Klema, Krishna Mohan Sepuru, Nadia Füllbrunn, Tierra R Farris, Paige S Dunphy, Jere W McBride, Krishna Rajarathnam, Kyung H Choi
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0194891 (2018)
Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis, secretes several effector proteins that bind host DNA to modulate host gene expression. The tandem repeat protein 120 (TRP120), one of the largest effector proteins, has
Externí odkaz:
https://doaj.org/article/323364a3ba5543abb73cfd9c9cb18991
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Platelet-derived chemokine CXCL7 (also known as NAP-2) plays a crucial role in orchestrating neutrophil recruitment in response to vascular injury. CXCL7 exerts its function by activating the CXC chemokine receptor 2 (CXCR2) receptor and binding sulf
Externí odkaz:
https://doaj.org/article/5ccc58a30a744d99a02ec781ccb4a591
Publikováno v:
Open Biology, Vol 7, Iss 11 (2017)
Chemokine CXCL8 plays a pivotal role in host immune response by recruiting neutrophils to the infection site. CXCL8 exists as monomers and dimers, and mediates recruitment by interacting with glycosaminoglycans (GAGs) and activating CXCR1 and CXCR2 r
Externí odkaz:
https://doaj.org/article/d47fc79357d846acaec5269f59673ab8
Publikováno v:
Molecules, Vol 23, Iss 11, p 2825 (2018)
Interleukin-8 (CXCL8), a potent neutrophil-activating chemokine, exerts its function by activating the CXCR1 receptor that belongs to class A G protein-coupled receptors (GPCRs). Receptor activation involves interactions between the CXCL8 N-terminal
Externí odkaz:
https://doaj.org/article/960a057752684c29940bb8e2111e5c5d
Autor:
Sarah Thompson, Beatriz Martínez-Burgo, Krishna Mohan Sepuru, Krishna Rajarathnam, John A. Kirby, Neil S. Sheerin, Simi Ali
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 8, p 1692 (2017)
The primary function of chemokines is to direct the migration of leukocytes to the site of injury during inflammation. The effects of chemokines are modulated by several means, including binding to G-protein coupled receptors (GPCRs), binding to glyc
Externí odkaz:
https://doaj.org/article/d83f2cff456f43b59388f18b44fff375
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 3, p 508 (2017)
CXCL7, a chemokine highly expressed in platelets, orchestrates neutrophil recruitment during thrombosis and related pathophysiological processes by interacting with CXCR2 receptor and sulfated glycosaminoglycans (GAG). CXCL7 exists as monomers and di
Externí odkaz:
https://doaj.org/article/47df4aafb3b74bbd824f23287df18da9
Solution structure of CXCL5--a novel chemokine and adipokine implicated in inflammation and obesity.
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93228 (2014)
The chemokine CXCL5 is selectively expressed in highly specialized cells such as epithelial type II cells in the lung and white adipose tissue macrophages in muscle, where it mediates diverse functions from combating microbial infections by regulatin
Externí odkaz:
https://doaj.org/article/98ab7e7db842476a921bd6545b742c9d
Autor:
Jose Sarmiento, Christie Shumate, Katsutoshi Suetomi, Aishwarya Ravindran, León Villegas, Krishna Rajarathnam, Javier Navarro
Publikováno v:
PLoS ONE, Vol 7, Iss 5 (2012)
Externí odkaz:
https://doaj.org/article/a8eed5db71254cf09ba559411f594b04