Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Krishna Prasadan"'
Autor:
Shakti Dahiya, Mohamed Saleh, Uylissa A. Rodriguez, Dhivyaa Rajasundaram, Jorge R. Arbujas, Arian Hajihassani, Kaiyuan Yang, Anuradha Sehrawat, Ranjeet Kalsi, Shiho Yoshida, Krishna Prasadan, Heiko Lickert, Jing Hu, Jon D. Piganelli, George K. Gittes, Farzad Esni
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Insufficient functional β-cell mass causes diabetes; however, an effective cell replacement therapy for curing diabetes is currently not available. Reprogramming of acinar cells toward functional insulin-producing cells would offer an abund
Externí odkaz:
https://doaj.org/article/e72094d086d54c24b74a96523b909ce6
Autor:
Ranjeet S. Kalsi, Alexander M. Kreger, Mohamed Saleh, Shiho Yoshida, Kartikeya Sharma, Joseph Fusco, Jami L. Saloman, Ting Zhang, Madison Thomas, Anuradha Sehrawat, Yan Wang, Jason Reif, Juliana Mills, Sarah Raad, Bugra Zengin, Ana Gomez, Aatur Singhi, Sameh Tadros, Adam Slivka, Farzad Esni, Krishna Prasadan, George Gittes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Chronic pancreatitis is a debilitating disease affecting millions worldwide. These patients suffer from bouts of severe pain that are minimally relieved by pain medications and may necessitate major surgeries with high morbidity and mortalit
Externí odkaz:
https://doaj.org/article/02b91bf8bc944deea70bf733168b753b
Autor:
Yinan Jiang, John Wiersch, Wei Wu, Jieqi Qian, Maharana Prathap R. Adama, Nannan Wu, Weixia Yang, Congde Chen, Lingyan Zhu, Krishna Prasadan, George K. Gittes, Xiangwei Xiao
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The contribution of bone-marrow derived cells (BMCs) to a newly formed beta-cell population in adults is controversial. Previous studies have only used models of bone marrow transplantation from sex-mismatched donors (or other models of genetic label
Externí odkaz:
https://doaj.org/article/f7f43671d9a346a792f989d459710c45
Autor:
Mylarappa Ningappa, Morayooluwa Adenuga, Kim A. Ngo, Nada Mohamed, Tejaswini Narayanan, Krishna Prasadan, Chethan Ashokkumar, Jishnu Das, Lori Schmitt, Hannah Hartman, Anuradha Sehrawat, Claudia M. Salgado, Miguel Reyes-Mugica, George K. Gittes, Cecilia W. Lo, Shankar Subramaniam, Rakesh Sindhi
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
BackgroundCiliary defects cause heterogenous phenotypes related to mutation burden which lead to impaired development. A previously reported homozygous deletion in the Man1a2 gene causes lethal respiratory failure in newborn pups and decreased lung c
Externí odkaz:
https://doaj.org/article/3f4d7397ddc74908a9f0fca602f5c229
Autor:
Juhoon So, Mylarappa Ningappa, Joseph Glessner, Jun Min, Chethan Ashokkumar, Sarangarajan Ranganathan, Brandon W. Higgs, Dong Li, Qing Sun, Lori Schmitt, Amy C. Biery, Steven Dobrowolski, Christine Trautz, Leah Fuhrman, Molly Christine Schwartz, Nikolai Thomas Klena, Joseph Fusco, Krishna Prasadan, Morayooluwa Adenuga, Nada Mohamed, Qi Yan, Wei Chen, William Horne, Anil Dhawan, Khalid Sharif, Deirdre Kelly, Robert H Squires, George K. Gittes, Hakon Hakonarson, Victor Morell, Cecilia Lo, Shankar Subramaniam, Donghun Shin, Rakesh Sindhi
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Background/AimsInfectious and genetic factors are invoked, respectively in isolated biliary atresia (BA), or syndromic BA, with major extrahepatic anomalies. However, isolated BA is also associated with minor extrahepatic gut and cardiovascular anoma
Externí odkaz:
https://doaj.org/article/e1c329030930403a8e3a5542aa7c32a8
Autor:
Weixia Yang, Yinan Jiang, Qun Liu, Chaoban Wang, Grant Swisher, Nannan Wu, Chelsea Chao, Krishna Prasadan, George K Gittes, Xiangwei Xiao
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
ObjectivePancreatic beta cells proliferate in response to metabolic requirements during pregnancy, while failure of this response may cause gestational diabetes. A member of the vascular endothelial growth factor family, placental growth factor (PlGF
Externí odkaz:
https://doaj.org/article/b4b7f552307d4fc890e2c94040aaed22
Autor:
Joseph Fusco, Xiangwei Xiao, Krishna Prasadan, Qingfeng Sheng, Congde Chen, Yung-Ching Ming, George Gittes
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
Abstract Exendin-4 is a long acting glucagon-like peptide 1 (GLP-1) analogue that is an agonist for the GLP-1 receptor, a G-protein coupled receptor (GPCR). Exendin-4 is used to clinically improve glucose tolerance in diabetic patients due to its abi
Externí odkaz:
https://doaj.org/article/adbf0b4c28d74aa08e9ef0b15bfa14d9
Autor:
Abrahim I. Orabi, Li Wen, Tanveer A. Javed, Tianming Le, Ping Guo, Subramaniam Sanker, David Ricks, Kristy Boggs, John F. Eisses, Carlos Castro, Xiangwei Xiao, Krishna Prasadan, Farzad Esni, George K. Gittes, Sohail Z. Husain
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 1, Pp 119-128 (2017)
Background & Aims: There is a pressing need to develop effective preventative therapies for postâendoscopic retrograde cholangiopancreatography pancreatitis (PEP). We showed that early PEP events are induced through the calcium-activated phosphatase
Externí odkaz:
https://doaj.org/article/769b11edcc3e473db6865e44af6f256c
Autor:
Yinan Jiang, Apeng Chen, Diana Kline, Qun Liu, Jie Ma, Yan Wang, Ting Zhang, Jieqi Qian, Laura Nelson, Krishna Prasadan, Baoli Hu, George K. Gittes, Xiangwei Xiao
Publikováno v:
Diabetes, Obesity and Metabolism. 24:1721-1733
To show that depletion of pancreatic macrophages impairs gestational beta cell proliferation and leads to glucose intolerance.Genetic animal models were applied to study the effects of depletion of pancreatic macrophges on gestational beta-cell proli
Publikováno v:
Biochemical Society Transactions
Diabetes mellitus is a significant cause of morbidity and mortality in the United States and worldwide. According to the CDC, in 2017, ∼34.2 million of the American population had diabetes. Also, in 2017, diabetes was the seventh leading cause of d