Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Krishna Madhavan"'
Autor:
Ilango Balakrishnan, Etienne Danis, Angela Pierce, Krishna Madhavan, Dong Wang, Nathan Dahl, Bridget Sanford, Diane K. Birks, Nate Davidson, Dennis S. Metselaar, Michaël Hananja Meel, Rakeb Lemma, Andrew Donson, Trinka Vijmasi, Hiroaki Katagi, Ismail Sola, Susan Fosmire, Irina Alimova, Jenna Steiner, Ahmed Gilani, Esther Hulleman, Natalie J. Serkova, Rintaro Hashizume, Cynthia Hawkins, Angel M. Carcaboso, Nalin Gupta, Michelle Monje, Nada Jabado, Kenneth Jones, Nicholas Foreman, Adam Green, Rajeev Vibhakar, Sujatha Venkataraman
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108286- (2020)
Summary: Diffuse intrinsic pontine glioma (DIPG) is an incurable brain tumor of childhood characterized by histone mutations at lysine 27, which results in epigenomic dysregulation. There has been a failure to develop effective treatment for this tum
Externí odkaz:
https://doaj.org/article/df550ba18a7344fb83017de0c06084bc
Autor:
Austin E. Gillen, Kent A. Riemondy, Vladimir Amani, Andrea M. Griesinger, Ahmed Gilani, Sujatha Venkataraman, Krishna Madhavan, Eric Prince, Bridget Sanford, Todd C. Hankinson, Michael H. Handler, Rajeev Vibhakar, Ken L. Jones, Siddhartha Mitra, Jay R. Hesselberth, Nicholas K. Foreman, Andrew M. Donson
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108023- (2020)
Summary: Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in most children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly confounds our understanding of EPN biology, impeding development
Externí odkaz:
https://doaj.org/article/86aaa43b961a406abbb08113d63ce8d6
Autor:
Nathan A. Dahl, Etienne Danis, Ilango Balakrishnan, Dong Wang, Angela Pierce, Faye M. Walker, Ahmed Gilani, Natalie J. Serkova, Krishna Madhavan, Susan Fosmire, Adam L. Green, Nicholas K. Foreman, Sujatha Venkataraman, Rajeev Vibhakar
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Histone 3 gene mutations are the eponymous drivers in diffuse midline gliomas (DMGs), aggressive pediatric brain cancers for which no curative therapy currently exists. These recurrent oncohistones induce a global loss of repressive H3K27me3
Externí odkaz:
https://doaj.org/article/658c8e9de95c4f8ea87a993cc17884db
Autor:
Lynn Zentner, Michael Zentner, Victoria Farnsworth, Michael McLennan, Krishna Madhavan, Gerhard Klimeck
Publikováno v:
Journal of Open Research Software, Vol 2, Iss 1, Pp e19-e19 (2014)
The science gateway nanoHUB.org, funded by the National Science Foundation (NSF), serves a large scientific community dedicated to research and education in nanotechnology with community-contributed simulation codes as well as a vast repository of ot
Externí odkaz:
https://doaj.org/article/82365b33946f4a91ba5050166f1f52ec
Autor:
Sujatha Venkataraman, Rajeev Vibhakar, Nathan A. Dahl, Siddhartha S. Mitra, Eva S. Nozik, Dong Wang, Faye Walker, Hanan B. Elajaili, Susan Fosmire, Bridget Sanford, Angela Pierce, Senthilnath Lakshmanachetty, Ilango Balakrishnan, Krishna Madhavan
Purpose:Tumor relapse after radiotherapy is a major hurdle in treating pediatric H3K27M-mutant diffuse midline gliomas (DMG). Radiotherapy-induced stress increases association of BCL2 family of proteins with BH3 pro-apoptotic activators preventing ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01549208de2627e19cf8265c987587d0
https://doi.org/10.1158/1078-0432.c.6532404
https://doi.org/10.1158/1078-0432.c.6532404
Autor:
Sujatha Venkataraman, Rajeev Vibhakar, Nathan A. Dahl, Siddhartha S. Mitra, Eva S. Nozik, Dong Wang, Faye Walker, Hanan B. Elajaili, Susan Fosmire, Bridget Sanford, Angela Pierce, Senthilnath Lakshmanachetty, Ilango Balakrishnan, Krishna Madhavan
Supplementary Figure from Venetoclax Cooperates with Ionizing Radiation to Attenuate Diffuse Midline Glioma Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b74cbe64a664f43743bf41435b3914
https://doi.org/10.1158/1078-0432.22486851.v1
https://doi.org/10.1158/1078-0432.22486851.v1
Autor:
Sujatha Venkataraman, Rajeev Vibhakar, Nathan A. Dahl, Siddhartha S. Mitra, Eva S. Nozik, Dong Wang, Faye Walker, Hanan B. Elajaili, Susan Fosmire, Bridget Sanford, Angela Pierce, Senthilnath Lakshmanachetty, Ilango Balakrishnan, Krishna Madhavan
Supplementary Table from Venetoclax Cooperates with Ionizing Radiation to Attenuate Diffuse Midline Glioma Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c63419401e286f3b69832fc2ce86fc4
https://doi.org/10.1158/1078-0432.22486845
https://doi.org/10.1158/1078-0432.22486845
Autor:
Krishna Madhavan, Ilango Balakrishnan, Senthilnath Lakshmanachetty, Angela Pierce, Bridget Sanford, Susan Fosmire, Hanan B. Elajaili, Faye Walker, Dong Wang, Eva S. Nozik, Siddhartha S. Mitra, Nathan A. Dahl, Rajeev Vibhakar, Sujatha Venkataraman
Publikováno v:
Clinical Cancer Research. 28:2409-2424
Purpose: Tumor relapse after radiotherapy is a major hurdle in treating pediatric H3K27M-mutant diffuse midline gliomas (DMG). Radiotherapy-induced stress increases association of BCL2 family of proteins with BH3 pro-apoptotic activators preventing a
Autor:
Irina Alimova, Dong Wang, Etienne Danis, Angela Pierce, Andrew Donson, Natalie Serkova, Krishna Madhavan, Senthilnath Lakshmanachetty, Ilango Balakrishnan, Nicholas Foreman, Siddhartha Mitra, Sujatha Venkataraman, Rajeev Vibhakar
Publikováno v:
International Journal of Oncology. 60
Atypical teratoid rhabdoid tumor (ATRT) is a highly aggressive pediatric brain tumor. Despite radiation, aggressive chemotherapy and autologous stem cell rescue, children usually have a poor survival time. In the present study, the role of TP53/MDM2
Publikováno v:
Neuro-Oncology. 24:vii220-vii220
There is an unmet need to identify novel targeted therapies for H3K27M mutated Diffuse Midline Gliomas. (DMG) Using genetic overexpression and deletion of H3K27M in model cells we identified high expression of CD99 mRNA in H3K27M-mutant expressing DI