Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Krishna M. Roskin"'
Autor:
Alicia Bedolla, Elliot Wegman, Max Weed, Messiyah K. Stevens, Kierra Ware, Aditi Paranjpe, Anastasia Alkhimovitch, Igal Ifergan, Aleksandr Taranov, Joshua D. Peter, Rosa Maria Salazar Gonzalez, J. Elliott Robinson, Lucas McClain, Krishna M. Roskin, Nigel H. Greig, Yu Luo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract While TGF-β signaling is essential for microglial function, the cellular source of TGF-β1 ligand and its spatial regulation remains unclear in the adult CNS. Our data supports that microglia but not astrocytes or neurons are the primary pr
Externí odkaz:
https://doaj.org/article/da033bed56594665960700b6c6a95a25
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionIllicit drug use, particularly the synthetic opioid fentanyl, presents a significant global health challenge. Previous studies have shown that fentanyl enhances viral replication; yet, the mechanisms by which it affects HIV pathogenesis r
Externí odkaz:
https://doaj.org/article/f811af2d95b24dd18f9cc1dc5e8cdcca
Autor:
Tiffany Shi, Ashley R. Burg, J. Timothy Caldwell, Krishna M. Roskin, Cyd M. Castro-Rojas, P. Chukwunalu Chukwuma, George I. Gray, Sara G. Foote, Jesus A. Alonso, Carla M. Cuda, David A. Allman, James S. Rush, Catherine H. Regnier, Grazyna Wieczorek, Rita R. Alloway, Adele R. Shields, Brian M. Baker, E. Steve Woodle, David A. Hildeman
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Bulk analysis of renal allograft biopsies (rBx) identified RNA transcripts associated with acute cellular rejection (ACR); however, these lacked cellular context critical to mechanistic understanding of how rejection occurs despite immunosuppression
Externí odkaz:
https://doaj.org/article/42e02f11da09405283e3b6ddcd572117
Autor:
James G. Williams, Rashika Joshi, David Haslam, Nadir Yehya, Rhonda L. Jones, Aditi Paranjpe, Mario Pujato, Krishna M. Roskin, Patrick M. Lahni, Hector R. Wong, Brian M. Varisco
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Rationale While nasal brushing transcriptomics can identify disease subtypes in chronic pulmonary diseases, it is unknown whether this is true in pediatric acute respiratory distress syndrome (PARDS). Objectives Determine whether nasal trans
Externí odkaz:
https://doaj.org/article/c9cdb5a7dc7a4ea498a7431e044d6be5
Autor:
Jason D. Merker, Krishna M. Roskin, Dana Ng, Cuiping Pan, Dianna G. Fisk, Jasmine J. King, Ramona Hoh, Michael Stadler, Lawrence M. Okumoto, Parveen Abidi, Rhonda Hewitt, Carol D. Jones, Linda Gojenola, Michael J. Clark, Bing Zhang, Athena M. Cherry, Tracy I. George, Michael Snyder, Scott D. Boyd, James L. Zehnder, Andrew Z. Fire, Jason Gotlib
Publikováno v:
Haematologica, Vol 98, Iss 11 (2013)
In order to identify novel somatic mutations associated with classic BCR/ABL1-negative myeloproliferative neoplasms, we performed high-coverage genome sequencing of DNA from peripheral blood granulocytes and cultured skin fibroblasts from a patient w
Externí odkaz:
https://doaj.org/article/115e569bec7d49db8c8c73908b664b8b
Autor:
Amy P. Rossi, Simon Tremblay, Cyd M. Castro-Rojas, Ashley A. Burg, Krishna M. Roskin, Jenna M. Gehman, Adele Rike-Shields, Rita R. Alloway, Paul Brailey, David Allman, David A. Hildeman, E. Steve Woodle
Publikováno v:
Am J Transplant
To date, plasma cell (PC)–targeted therapies have been limited by suboptimal PC depletion and antibody rebound. We hypothesized this is partly because of PC residence in protective bone marrow (BM) microenvironments. The purpose of this proof-of-co
Autor:
Kirandeep Gill, Carolina Moore, Onyekachi Nwogu, John W. Kroner, Wan-Chi Chang, Mariana L. Stevens, Asel Baatyrbek kyzy, Jocelyn M. Biagini, Ashley L. Devonshire, Leah Kottyan, Justin T. Schwartz, Amal H. Assa’ad, Lisa J. Martin, Sandra Andorf, Gurjit K. Khurana Hershey, Krishna M. Roskin
Publikováno v:
bioRxiv
The skin is a major immune organ and skin barrier dysfunction is a major risk factor for the development of the inappropriate immune response seen in allergic disease. Skin barrier disruption alters the landscape of antigens experienced by the immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a682df0fdc5217edee2ca2175eec2dfd
https://europepmc.org/articles/PMC9915585/
https://europepmc.org/articles/PMC9915585/
Autor:
Stephen B. Montgomery, Mark D. Ewalt, Beth A. Pitel, Hutton M. Kearney, Laure Fresard, Robert S. Ohgami, Jason D. Merker, Athena M. Cherry, Yanli Hou, Jason Gotlib, Daniel A. Arber, Charles D. Bangs, Linda B. Baughn, Justin A. Chen, Krishna M. Roskin, Andrew Fire, Kathryn E. Pearce
Publikováno v:
Blood Adv
The basis for acquired resistance to JAK inhibition in patients with JAK2-driven hematologic malignancies is not well understood. We report a patient with a myeloproliferative neoplasm (MPN) with a BCR activator of RhoGEF and GTPase (BCR)–JAK2 fusi
Autor:
Khoa D. Nguyen, Grace H. Jean, Claus U. Niemann, Katherine J. L. Jackson, Tho D. Pham, Ramona A. Hoh, Emily Haraguchi, Katharina Röltgen, Julie Parsonnet, Yi Liu, Sandra C. A. Nielsen, Fan Yang, Kari C. Nadeau, Ji-Yeun Lee, Scott D. Boyd, Krishna M. Roskin, Robert S. Ohgami, Eleanor M. Osborne, Oliver F. Wirz
Publikováno v:
Science (New York, N.y.)
Kids armed with anti-coronavirus B cells It remains unclear whether B cell repertoires against coronaviruses and other pathogens differ between adults and children and how important these distinctions are. Yang et al. analyzed blood samples from youn
Autor:
Maxim E. Zaslavsky, Erin Craig, Jackson K. Michuda, Nikhil Ram-Mohan, Ji-Yeun Lee, Khoa D. Nguyen, Ramona A. Hoh, Tho D. Pham, Ella S. Parsons, Susan R. Macwana, Wade DeJager, Krishna M. Roskin, Charlotte Cunningham-Rundles, M. Anthony Moody, Barton F. Haynes, Jason D. Goldman, James R. Heath, Imelda Balboni, Paul J Utz, Kari C. Nadeau, Benjamin A. Pinsky, Catherine A. Blish, Joan T. Merrill, Joel M. Guthridge, Judith A. James, Samuel Yang, Robert Tibshirani, Anshul Kundaje, Scott D. Boyd
Publikováno v:
bioRxiv
Clinical diagnoses rely on a wide variety of laboratory tests and imaging studies, interpreted alongside physical examination findings and the patient’s history and symptoms. Currently, the tools of diagnosis make limited use of the immune system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4cd44661ef1674147cb8d4a12cdb04a
https://doi.org/10.1101/2022.04.26.489314
https://doi.org/10.1101/2022.04.26.489314