Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Krishna K. Sarangapani"'
Dividing cells detect and correct erroneous kinetochore-microtubule attachments during mitosis, thereby avoiding chromosome mis-segregation. Most studies of this process have focused on the Aurora B kinase, which phosphorylates microtubule-binding el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3013cdad86daac44fac61bd0b9579a4d
https://doi.org/10.1101/2021.04.25.441339
https://doi.org/10.1101/2021.04.25.441339
Autor:
Weronika E, Borek, Nadine, Vincenten, Eris, Duro, Vasso, Makrantoni, Christos, Spanos, Krishna K, Sarangapani, Flavia, de Lima Alves, David A, Kelly, Charles L, Asbury, Juri, Rappsilber, Adele L, Marston
Publikováno v:
Current Biology
Summary Kinetochores direct chromosome segregation in mitosis and meiosis. Faithful gamete formation through meiosis requires that kinetochores take on new functions that impact homolog pairing, recombination, and the orientation of kinetochore attac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cca78efcc4953336687940df17eb2954
https://pubmed.ncbi.nlm.nih.gov/33157029
https://pubmed.ncbi.nlm.nih.gov/33157029
Autor:
Kimberly K. Fong, Erik Yusko, Beth Graczyk, Trisha N. Davis, Michael Riffle, Aida Llauró, Charles L. Asbury, Krishna K. Sarangapani
Publikováno v:
Molecular Biology of the Cell
Laser trapping is used to manipulate single attached microtubules in vitro. Direct mechanical measurement shows that attachment of microtubule minus ends to yeast spindle pole bodies is extraordinarily strong.
Centrosomes, or spindle pole bodies
Centrosomes, or spindle pole bodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a631723edec60c2949f31e69b5e903
https://doi.org/10.1091/mbc.e17-01-0034
https://doi.org/10.1091/mbc.e17-01-0034
Autor:
Juri Rappsilber, Eris Duro, Nadine Vincenten, David A. Kelly, Christos Spanos, Adele L. Marston, Flavia de Lima Alves, Weronika E. Borek, Charles L. Asbury, Vasso Makrantoni, Krishna K. Sarangapani
Publikováno v:
Borek, W, Vincenten, N, Duro, E, Makrantoni, V, Spanos, C, Sarangapani, K K, de Lima Alves, F, Kelly, D, Asbury, C L, Rappsilber, J & Marston, A L 2021, ' The proteomic landscape of centromeric chromatin reveals an essential role for the Ctf19CCAN complex in meiotic kinetochore assembly ', Current Biology, vol. 31, no. 2, pp. P283-296.E7 . https://doi.org/10.1016/j.cub.2020.10.025
Kinetochores direct chromosome segregation in mitosis and meiosis. Faithful gamete formation through meiosis requires that kinetochores take on new functions that impact homolog pairing, recombination and the orientation of kinetochore attachment to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2be3b9e1f00f0953f5794eef312cac
https://doi.org/10.1016/j.cub.2020.10.025
https://doi.org/10.1016/j.cub.2020.10.025
Publikováno v:
Trends in Genetics. 30:150-159
Sport fishermen keep tension on their lines to prevent hooked fish from releasing. A molecular version of this angler's trick, operating at kinetochores, ensures accuracy during mitosis: the mitotic spindle attaches randomly to chromosomes and then c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755077780bb84c1c2373e048a9ba65f9
https://doi.org/10.1016/j.tig.2014.02.004
https://doi.org/10.1016/j.tig.2014.02.004
Autor:
Krishna K. Sarangapani, Wei Chen, Veronika I. Zarnitsyna, Rodger P. McEver, Padmaja Mehta, Tadayuki Yago, Cheng Zhu, Jin Qian
Publikováno v:
Journal of Biological Chemistry. 286:32749-32761
The current paradigm for receptor-ligand dissociation kinetics assumes off-rates as functions of instantaneous force without impact from its prior history. This a priori assumption is the foundation for predicting dissociation from a given initial st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e6d6377aa9dd7d3cde5d7431c17cc1
https://doi.org/10.1074/jbc.m111.240044
https://doi.org/10.1074/jbc.m111.240044
Publikováno v:
European Biophysics Journal. 39:1219-1227
Atomic force microscopy (AFM)-based dynamic force spectroscopy of single molecular interactions involves characterizing unbinding/unfolding force distributions over a range of pulling speeds. Owing to their size and stiffness, AFM cantilevers are adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d56571da74b071ce7d1ebff17901f0
https://doi.org/10.1007/s00249-009-0575-1
https://doi.org/10.1007/s00249-009-0575-1
Publikováno v:
Biophysical Journal. 88(2):1458-1466
Receptor-ligand bonds that mediate cell adhesion are often subjected to forces that regulate their dissociation via modulating off-rates. Off-rates control how long receptor-ligand bonds last and how much force they withstand. One should therefore be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43939e796d8fb87e1b558ba3a12b9f15
Autor:
Cheng Zhu, Tadayuki Yago, Arkadiusz G. Klopocki, Claudia B. Fieger, Krishna K. Sarangapani, Steven D. Rosen, Rodger P. McEver, Michael B. Lawrence
Publikováno v:
Journal of Biological Chemistry. 279:2291-2298
Selectin-ligand interactions mediate the tethering and rolling of circulating leukocytes on vascular surfaces during inflammation and immune surveillance. To support rolling, these interactions are thought to have rapid off-rates that increase slowly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87455e5d733743624efe47956f8bc0b0
https://doi.org/10.1074/jbc.m310396200
https://doi.org/10.1074/jbc.m310396200