Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Krishna C. Chinta"'
Autor:
Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, Sajid Nadeem, Ritesh R. Sevalkar, Kievershen Nargan, Kapongo Lumamba, Threnesan Naidoo, Joel N. Glasgow, Anupam Agarwal, Adrie J. C. Steyn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Mycobacterium tuberculosis (Mtb) disrupts glycolytic flux in infected myeloid cells through an unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably linked to the availability of NAD+, which is maintained by
Externí odkaz:
https://doaj.org/article/4e4ad46f3eb246c2ab7a16acbf265d77
Autor:
Vikram Saini, Krishna C. Chinta, Vineel P. Reddy, Joel N. Glasgow, Asaf Stein, Dirk A. Lamprecht, Md. Aejazur Rahman, Jared S. Mackenzie, Barry E. Truebody, John H. Adamson, Tafara T. R. Kunota, Shannon M. Bailey, Douglas R. Moellering, Jack R. Lancaster, Adrie J. C. Steyn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The importance of host-produced hydrogen sulfide (H2S) in microbial pathogenesis is poorly understood. Here, Saini et al. show that H2S alters Mycobacterium tuberculosis (Mtb) central metabolism, stimulates respiration to promote growth and TB diseas
Externí odkaz:
https://doaj.org/article/20fabbdfe15b499283f6565afa5077d3
Autor:
Krishna C. Chinta, Md. Aejazur Rahman, Vikram Saini, Joel N. Glasgow, Vineel P. Reddy, Jeremie M. Lever, Shepherd Nhamoyebonde, Alasdair Leslie, Ryan M. Wells, Amie Traylor, Rajhmun Madansein, Gene P. Siegal, Veena B. Antony, Jessy Deshane, Gordon Wells, Kievershen Nargan, James F. George, Pratistadevi K. Ramdial, Anupam Agarwal, Adrie J.C. Steyn
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1938-1952.e5 (2018)
Summary: Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that controls inflammatory responses and redox homeostasis; however, its role during pulmonary tuberculosis (TB) remains unclear. Using freshly resected human TB lung tissue, we examined the
Externí odkaz:
https://doaj.org/article/4c7da74431894b99aa2b05cd2ea1ba01
Publikováno v:
Antioxidants, Vol 10, Iss 2, p 177 (2021)
Excessive inflammation and tissue damage are pathological hallmarks of chronic pulmonary tuberculosis (TB). Despite decades of research, host regulation of these clinical consequences is poorly understood. A sustained effort has been made to understa
Externí odkaz:
https://doaj.org/article/5be2bb2524754e6c8eb8e44f2873be29
Autor:
Vikram Saini, Bridgette M. Cumming, Loni Guidry, Dirk A. Lamprecht, John H. Adamson, Vineel P. Reddy, Krishna C. Chinta, James H. Mazorodze, Joel N. Glasgow, Melissa Richard-Greenblatt, Anaximandro Gomez-Velasco, Horacio Bach, Yossef Av-Gay, Hyungjin Eoh, Kyu Rhee, Adrie J.C. Steyn
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 572-585 (2016)
The mechanisms by which Mycobacterium tuberculosis (Mtb) maintains metabolic equilibrium to survive during infection and upon exposure to antimycobacterial drugs are poorly characterized. Ergothioneine (EGT) and mycothiol (MSH) are the major redox bu
Externí odkaz:
https://doaj.org/article/e86030a4d9474eae8ff100fea63540c3
Autor:
Vineel P. Reddy, Krishna C. Chinta, Vikram Saini, Joel N. Glasgow, Travis D. Hull, Amie Traylor, Fernanda Rey-Stolle, Miguel P. Soares, Rajhmun Madansein, Md Aejazur Rahman, Coral Barbas, Kievershen Nargan, Threnesan Naidoo, Pratistadevi K. Ramdial, James F. George, Anupam Agarwal, Adrie J. C. Steyn
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Iron is an essential factor for the growth and virulence of Mycobacterium tuberculosis (Mtb). However, little is known about the mechanisms by which the host controls iron availability during infection. Since ferritin heavy chain (FtH) is a major int
Externí odkaz:
https://doaj.org/article/d79a2cc979e84fa6981d72ac6c9ff227
Autor:
Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, Sajid Nadeem, Ritesh R. Sevalkar, Kierveshan Nargan, Kapongo Lumamba, Threnesan Naidoo, Joel N. Glasgow, Anupam Agarwal, Adrie J. C. Steyn
Mycobacterium tuberculosis (Mtb) disrupts glycolytic flux in infected myeloid cells through an unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably linked to the availability of NAD+, which is maintained by NAD+ sal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2cdf01b8274064bd279cb8daf99a352
https://doi.org/10.1101/2022.09.11.507472
https://doi.org/10.1101/2022.09.11.507472
Autor:
Asaf Stein, Jack R. Lancaster, Tafara T.R. Kunota, Shannon M. Bailey, Jared S. Mackenzie, Dirk A. Lamprecht, Adrie J. C. Steyn, Vineel P. Reddy, Krishna C. Chinta, Vikram Saini, Barry E. Truebody, Douglas R. Moellering, Md. Aejazur Rahman, John H. Adamson, Joel N. Glasgow
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Hydrogen sulfide (H2S) is involved in numerous pathophysiological processes and shares overlapping functions with CO and •NO. However, the importance of host-derived H2S in microbial pathogenesis is unknown. Here we show that Mtb-infected mice defi
Autor:
Hayden T, Pacl, Jennifer L, Tipper, Ritesh R, Sevalkar, Andrew, Crouse, Camerron, Crowder, Shama, Ahmad, Aftab, Ahmad, Gillian D, Holder, Charles J, Kuhlman, Krishna C, Chinta, Sajid, Nadeem, Todd J, Green, Chad M, Petit, Adrie J C, Steyn, Matthew, Might, Kevin S, Harrod
Publikováno v:
bioRxiv
SummaryThe recent emergence of a novel coronavirus, SARS-CoV-2, has led to the global pandemic of the severe disease COVID-19 in humans. While efforts to quickly identify effective antiviral therapies have focused largely on repurposing existing drug
Publikováno v:
Antioxidants & Redox Signaling
Significance: L-ergothioneine is synthesized in actinomycetes, cyanobacteria, methylobacteria, and some fungi. In contrast to other low-molecular-weight redox buffers, glutathione and mycothiol, ergothioneine is primarily present as a thione rather t