Výsledky vyhledávání - "Krishna, Deepak"

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DECO: Liberating Web Data Using Decentralized Oracles for TLS

Autor: Zhang, Fan, Maram, Sai Krishna Deepak, Malvai, Harjasleen, Goldfeder, Steven, Juels, Ari

Thanks to the widespread deployment of TLS, users can access private data over channels with end-to-end confidentiality and integrity. What they cannot do, however, is prove to third parties the {\em provenance} of such data, i.e., that it genuinely

Externí odkaz: http://arxiv.org/abs/1909.00938

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Akademický článek

Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism

Autor: Andra C. Dumitru, R. N. V. Krishna Deepak, Heng Liu, Melanie Koehler, Cheng Zhang, Hao Fan, David Alsteens

Publikováno v: Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)

Dumitru et al. probe the ligand-binding mechanism and activation of the human G protein-coupled C5a receptor (C5aR) and discover a cooperativity between the two orthosteric binding sites. Their findings, probing the dynamic aspects of receptor–liga

Externí odkaz: https://doaj.org/article/443aebd51a024799afe9304b404255fe

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Akademický článek

SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility

Publikováno v: Cell Reports, Vol 35, Iss 3, Pp 109025- (2021)

Summary: Ablation of Slc22a14 causes male infertility in mice, but the underlying mechanisms remain unknown. Here, we show that SLC22A14 is a riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa mid-piece and show b

Externí odkaz: https://doaj.org/article/bf6c865da545426caec55f4e1189d344

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Akademický článek

Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery

Autor: R. N. V. Krishna Deepak, Ravi Kumar Verma, Yossa Dwi Hartono, Wen Shan Yew, Hao Fan

Publikováno v: Pharmaceuticals, Vol 15, Iss 1, p 12 (2021)

Great progress has been made over the past decade in understanding the structural, functional, and pharmacological diversity of lipid GPCRs. From the first determination of the crystal structure of bovine rhodopsin in 2000, much progress has been mad

Externí odkaz: https://doaj.org/article/38d6388569594c49802b2c5b5a978725

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