Zobrazeno 1 - 10 of 102 pro vyhledávání: '"Krishna, Chuttani"'
1
Akademický článek
Mucoadhesive microemulsion of ibuprofen: design and evaluation for brain targeting efficiency through intranasal route
Autor: Surjyanarayan Mandal, Snigdha Das Mandal, Krishna Chuttani, Bharat Bhushan Subudhi
Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 51, Iss 3, Pp 721-731 (2015)
This study aimed at designing mucoadhesive microemulsion gel to enhance the brain uptake of Ibuprofen through intranasal route. Ibuprofen loaded mucoadhesive microemulsion (MMEI) was developed by incorporating polycarbophil as mucoadhesive polymer in
Externí odkaz: https://doaj.org/article/e9c6fe32794f4d3496b2d250e7a3e933
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2
Akademický článek
Preclinical Evaluation of a Potential GSH Ester Based PET/SPECT Imaging Probe DT(GSHMe)₂ to Detect Gamma Glutamyl Transferase Over Expressing Tumors.
Autor: Harleen Khurana, Virendra Kumar Meena, Surbhi Prakash, Krishna Chuttani, Nidhi Chadha, Ambika Jaswal, Devinder Kumar Dhawan, Anil Kumar Mishra, Puja Panwar Hazari
Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0134281 (2015)
Gamma Glutamyl Transferase (GGT) is an important biomarker in malignant cancers. The redox processes ensuing from GGT-mediated metabolism of extracellular GSH are implicated in critical aspects of tumor cell biology. Reportedly, Glutathione monoethyl
Externí odkaz: https://doaj.org/article/96682e9fda45492db28a4a0ae154769f
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5
Luteinizing hormone-releasing hormone peptide tethered nanoparticulate system for enhanced antitumoral efficacy of paclitaxel
Autor: Rakesh K. Tekade, Krishna Chuttani, Anil Mishra, Narendra K. Jain, Raksha Ghanghoria
Publikováno v: Nanomedicine. 11:797-816
Aim: Paclitaxel (PTX) is an effective anticancer agent used in the therapy of a wide variety of cancers. However, the drug is difficult to formulate due to its low solubility, and therefore, it is administered under slow infusion with castor oil/etha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbdc76c42e52923dd48fb363aef94d6
https://doi.org/10.2217/nnm.16.19
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6
Synthesis, preclinical evaluation and molecular modelling of macrocyclic appended 1-(2-methoxyphenyl)piperazine for 5-HT1A neuroreceptor imaging
Autor: Surbhi Prakash, Nidhi Chadha, Virendra Kumar Meena, Krishna Chuttani, Niraj K. Singh, Puja Panwar Hazari, Anil K. Mishra, Shrikant Kukreti, Pooja Singh
Publikováno v: RSC Advances. 6:7288-7301
5-HT1A receptors are known to be implicit in a number of neuropsychiatric fluctuations related to mood and anxiety. Their visualization in the human brain using PET, SPECT or MRI is of great importance in the management and treatment of neurological
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::941eb7621ed8eb387e75cfc94e4dfb23
https://doi.org/10.1039/c5ra13432c
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7
Preclinical Study of Ibuprofen Loaded Transnasal Mucoadhesive Microemulsion for Neuroprotective Effect in MPTP Mice Model
Autor: Surjyanarayan, Mandal, Snigdha Das, Mandal, Krishna, Chuttani, Krutika K, Sawant, Bharat Bhushan, Subudhi
Publikováno v: Iranian Journal of Pharmaceutical Research : IJPR
Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), showed very promising neuroprotection action, but it suffers from high first pass metabolism and limited ability to cross blood brain barrier. Severe gastric toxicity following oral administr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f383e5cd86ff069790388e736c6b570
https://pubmed.ncbi.nlm.nih.gov/29755536
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8
Anxiolytic actions of Nardostachys jatamansi via GABA benzodiazepine channel complex mechanism and its biodistribution studies
Autor: M. P. Venuprasad, Farhath Khanum, Anil K. Mishra, Krishna Chuttani, Hemanth Kumar Kandikattu, Sakina Razack, Narayanappa Amruta
Publikováno v: Metabolic brain disease. 33(5)
Nardostachys jatamansi has profound applications against pharmacological interventions and is categorized as a hypno-sedative drug according to Ayurveda. In the present study probable mechanism of anxiolytic action of Nardostachys jatamansi extract (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffe71baf4db238457b8a199f8962d48
https://pubmed.ncbi.nlm.nih.gov/29934858
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9
Neuroprotective effect of ibuprofen by intranasal application of mucoadhesive nanoemulsion in MPTP induced Parkinson model
Autor: Krishna Chuttani, Bharat Bhushan Subudhi, Krutika K Sawant, Surjyanarayan Mandal, Snigdha Das Mandal
Publikováno v: Journal of Pharmaceutical Investigation. 46:41-53
This study was to investigate the neuroprotective effect of Ibuprofen by intranasal route against inflammation-mediated by dopaminergic neurodegeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice model of Parkinson’s disease (PD).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b6570bca4e5628b4e2089e3ea069ad1
https://doi.org/10.1007/s40005-015-0212-1
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10
99mTc labeled macrocyclic aza-oxa and aza-thia probes: synthesis, characterization and in vitro & in vivo biological studies
Autor: Krishna Chuttani, Bachcha Singh, Anil Mishra, Neelam Yadav
Publikováno v: Journal of Inclusion Phenomena and Macrocyclic Chemistry. 83:299-307
Macrocyclic chelating agents 1-oxa-4,7,10-triazacyclopentadecane-3,11-dione (OTDD) and 1-thia-4,7, 10-triazacyclododecane-3,11-dione (TTDD) have been synthesized and labeled with radionuclide (99mTc), with radiolabeling efficiency 97.6 and 98.4 % res
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48ebc387d9d5868971ab86bb76ad1ad0
https://doi.org/10.1007/s10847-015-0565-0
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