Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Krishana Gulla"'
Autor:
Nicole Cibelli, Gabriel Arias, McKenzie Figur, Shireen S. Khayat, Kristin Leach, Ivan Loukinov, William Shadrick, Watchalee Chuenchor, Yaroslav Tsybovsky, Vaccine Production Program Analytical Development, Krishana Gulla, Daniel B. Gowetski
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The spike (S) glycoprotein of the pandemic virus, SARS-CoV-2, is a critically important target of vaccine design and therapeutic development. A high-yield, scalable, cGMP-compliant downstream process for the stabilized, soluble, native-like
Externí odkaz:
https://doaj.org/article/2090d4c8bd3043d1a35194982b3239e5
Autor:
Li Ou, Krishana Gulla, Andrea Biju, Daniel W. Biner, Tatsiana Bylund, Anita Changela, Steven J. Chen, Cheng-Yan Zheng, Nicole Cibelli, Angela R. Corrigan, Hongying Duan, Christopher A. Gonelli, Wing-Pui Kong, Cheng Cheng, Sijy O’Dell, Edward K. Sarfo, Andrew Shaddeau, Shuishu Wang, Alison Vinitsky, Yanhong Yang, Baoshan Zhang, Yaqiu Zhang, Richard A. Koup, Nicole A. Doria-Rose, Jason G. Gall, John R. Mascola, Peter D. Kwong
Publikováno v:
Vaccines, Vol 10, Iss 11, p 1916 (2022)
Conjugate-vaccine immunogens require three components: a carrier protein, an antigen, and a crosslinker, capable of coupling antigen to carrier protein, while preserving both T-cell responses from carrier protein and B-cell responses from antigen. We
Externí odkaz:
https://doaj.org/article/85de9bcde4414298a03518a9e4924ae9
Autor:
Kirsten E Lyke, Andrea A Berry, Kaitlin Mason, Azza H Idris, Mark O'Callahan, Myra Happe, Larisa Strom, Nina M Berkowitz, Mercy Guech, Zonghui Hu, Mike Castro, Manjula Basappa, Lu Wang, Kwang Low, LaSonji A Holman, Floreliz Mendoza, Ingelise J Gordon, Sarah H Plummer, Olga Trofymenko, Kathleen S Strauss, Sudhaunshu Joshi, Biraj Shrestha, Matthew Adams, Andrezza Campos Chagas, Jittawadee R Murphy, Judy Stein, Somia Hickman, Andrew McDougal, Bob Lin, Sandeep R Narpala, Sandra Vazquez, Leonid Serebryannyy, Adrian McDermott, Martin R Gaudinski, Edmund V Capparelli, Emily E Coates, Richard L Wu, Julie E Ledgerwood, Lesia K Dropulic, Robert A Seder, Cheryl Young, Colleen Boyce, Jennifer Winkler, Susan Holian, Nancy Greenberg, Shirley George, Alyson Kwon, Brenda Dorsey, Ana Raquel Da Costa, William Witt, Daryl Grays, Arren Gapasin, Paula Bernal, Jeffrey Floyd, Eric Goldstein, Leslie Howe, Myounghee Lee, Jennifer Marron, Kelly Brooks, Lisa Turek, Patricia Farley, Shantel Frels, Delores Booth, Jason Gall, Kevin Carlton, Gabriela Albright, Nadia Amharref, Kandace Atallah, Sashikanth Banappagari, Niutish Bastani, Daniel Blackstock, Bobby Boonyaratanakornkit, Elizabeth Carey, Adam Charlton, Rajoshi Chaudhuri, Alegria M. Caringal, Mingzhong Chen, Peifeng Chen, Wei Cheng, Daniel Gowetski, Krishana Gulla, Erica Hastings, Joe Horwitz, Vera Ivleva, Dan Kordella, Lisa A. Kueltzo, Sara Lagler, Matt Le, James Lee, Paula Lei, Yile Li, Attila Nagy, Aakash Patel, Peyi Runsewe, Will Shadrick, Shamitha Shetty, Hairong Wang, Calvin Webber, Farah Vejzagic, Yoo-Jung Yang
Publikováno v:
The Lancet Infectious Diseases. 23:578-588
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f600caf7a91af2dc3f76ba29b4af090
https://doi.org/10.1016/s1473-3099(22)00793-9
https://doi.org/10.1016/s1473-3099(22)00793-9
Autor:
McKenzie Figur, Ivan Loukinov, Nicole L. Cibelli, Kristin Leach, Krishana Gulla, Daniel B. Gowetski, Gabriel F. Arias, Shireen Khayat
Publikováno v:
Research Square
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
The spike (S) glycoprotein of the pandemic virus, SARS-CoV-2, is a critically important target of vaccine design and therapeutic development. A high-yield, scalable, cGMP-compliant downstream process for the stabilized, soluble, native-like S protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61890fe7b71f8ba168a505d59c9097ef
https://pubmed.ncbi.nlm.nih.gov/35292666
https://pubmed.ncbi.nlm.nih.gov/35292666
Autor:
Daniel B. Gowetski, Zachary J. Schneiderman, David Cetlin, Sarah O’Connell, Nicole L. Cibelli, Gabriel F. Arias, Krishana Gulla
Publikováno v:
Biotechnology journalREFERENCES. 16(9)
High throughput process development (HTPD) using liquid handling robotics and RoboColumns is an established methodology in downstream process development to screen chromatography resins and optimize process designs to meet target product profiles. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9a050a42c904715c5d6d3d2c2e8314
https://pubmed.ncbi.nlm.nih.gov/34174016
https://pubmed.ncbi.nlm.nih.gov/34174016
Autor:
Vrc Production Program, Anita Changela, Yaqiu Zhang, Sandeep Narpala, Daniel B. Gowetski, Krishana Gulla, Christian Hatcher, Zachary J. Schneiderman, Peter D. Kwong, Yaroslav Tsybovsky, Hui Geng, Nicole L. Cibelli, Sara Witter, Adrian B. McDermott, Jonathan W. Cooper, Haley C Fuller, Baoshan Zhang
Publikováno v:
Vaccine
Metastable glycosylated immunogens present challenges for GMP manufacturing. The HIV-1 envelope (Env) glycoprotein trimer is covered by N-linked glycan comprising half its mass and requires both trimer assembly and subunit cleavage to fold into a pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e72292f02d9422f1152ea4932538389
https://pubmed.ncbi.nlm.nih.gov/34020817
https://pubmed.ncbi.nlm.nih.gov/34020817
Autor:
Raffaello Verardi, Peter D. Kwong, Reda Rawi, Rui Kong, John R. Mascola, Edward T. Ryan, Frank J. Arnold, Yaqiu Zhang, Timothy G. Wanninger, Wing-Pui Kong, Andrew Shaddeau, Yaroslav Tsybovsky, Aliaksandr Druz, Krisha McKee, Cara W. Chao, Shuishu Wang, Li Ou, Krishana Gulla, Gengcheng J. Yang, Tongqing Zhou, Arne Schön, Kai Xu, Sijy O'Dell, Nathan Barefoot, Willie F. Vann, Cheng Cheng, Q. Paula Lei, Gwo-Yu Chuang, Mridul Ghosh, Baoshan Zhang, Edward K Sarfo, Nicole A. Doria-Rose, Joseph Varriale, Vrc Production Program, Anita Changela
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
The vaccine elicitation of broadly neutralizing antibodies against HIV-1 is a long-sought goal. We previously reported the amino-terminal eight residues of the HIV-1-fusion peptide (FP8) – when conjugated to the carrier protein, keyhole limpet hemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db06e4e378773a474101f87640a85479
https://doi.org/10.1038/s41598-020-59711-y
https://doi.org/10.1038/s41598-020-59711-y
Autor:
Yile Li, Li Ou, Yanhong Yang, Gengcheng J. Yang, Krishana Gulla, Jonathan W. Cooper, Cindy X. Cai, Q. Paula Lei, Yaqiu Zhang, Andrew Shaddeau
Publikováno v:
Vaccine. 38(29)
An N-terminal peptide of the HIV-1 fusion peptide (FP) with eight amino acid residues (FP8) was conjugated to a recombinant Tetanus Toxoid Heavy Chain Fragment C (rTTHc) as a carrier protein to help boosting immunogenicity against HIV-1. In this rapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fcd60ca2b3b76eebc45e4a28575f68
https://pubmed.ncbi.nlm.nih.gov/32448620
https://pubmed.ncbi.nlm.nih.gov/32448620
Autor:
Krishana Gulla, Q. Paula Lei, Cindy X. Cai, Nicole A. Schneck, Vera B. Ivleva, Daniel B. Gowetski, Yaqiu Zhang
Publikováno v:
J Chromatogr B Analyt Technol Biomed Life Sci
A fusion peptide mimicking a part of the sequence of HIV-1 envelope glycoprotein with an additional cysteine at its C-terminus (FP8: AVGIGAVFC) was conjugated to a carrier protein through a linker for development of an HIV-1 vaccine. Since this fusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b681a2f5e3446c36027a6e58b33f573
https://doi.org/10.1016/j.jchromb.2020.122073
https://doi.org/10.1016/j.jchromb.2020.122073