Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Kris de Boeck"'
Autor:
Elpis Hatziagorou, Steffen Fieuws, Annalisa Orenti, Lutz Naehrlich, Uros Krivec, Meir Mei-Zahav, Andreas Jung, Kris De Boeck, on behalf of the ECFSPR Collaborative Group, Pfleger Andreas
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2023)
Aim To examine the trajectory of forced expiratory volume in 1 s (FEV1) using data from the European Cystic Fibrosis Society patient registry (ECFPR) collected from 2008 to 2016, i.e. the era before highly effective modulator therapy (HEMT). We evalu
Externí odkaz:
https://doaj.org/article/b1994312399147b8ba078f0ca8b4aace
Autor:
L. Clara Mok, Antonio Garcia-Uceda, Matthew N. Cooper, Mariette Kemner-Van De Corput, Marleen De Bruijne, Nathalie Feyaerts, Tim Rosenow, Kris De Boeck, Stephen Stick, Harm A. W. M. Tiddens
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Newly developed quantitative chest computed tomography (CT) outcomes designed specifically to assess structural abnormalities related to cystic fibrosis (CF) lung disease are now available. CFTR modulators potentially can reduce some stru
Externí odkaz:
https://doaj.org/article/0db01b0d7a1a4536ad45674e6cd8ad75
Autor:
Meredith C. Fidler, Alexandra Buckley, James C. Sullivan, Marvin Statia, Sylvia F. Boj, Robert G. J. Vries, Anne Munck, Mark Higgins, Matteo Moretto Zita, Paul Negulescu, Fredrick vanGoor, Kris De Boeck
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 656-663 (2021)
In previous work, participants with a G970R mutation in cystic fibrosis transmembrane conductance regulator (CFTR) (c.2908G>C) had numerically lower sweat chloride responses during ivacaftor treatment than participants with other CFTR gating mutation
Externí odkaz:
https://doaj.org/article/da813cb3faa54b46b8f5eeca152ec374
Autor:
Joseph M. Pilewski, Kris De Boeck, Jerry A. Nick, Simon Tian, Cynthia DeSouza, Mark Higgins, Richard B. Moss
Publikováno v:
Pulmonary Therapy, Vol 6, Iss 2, Pp 303-313 (2020)
Abstract Introduction Mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR) affect the quantity and/or function of CFTR protein reaching the cell surface. Ivacaftor, a CFTR potentiator that enhances chloride transport, incr
Externí odkaz:
https://doaj.org/article/d1ffc021999545a895f77d451a3ee977
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Objectives: Cystic fibrosis transmembrane conductance regulator (CFTR) modulators, Kalydeco® (ivacaftor), Orkambi® (lumacaftor/ivacaftor) and Symkevi® (tezacaftor/ivacaftor), have substantially improved patients’ lives yet significantly burden h
Externí odkaz:
https://doaj.org/article/54c83bf9580b4210b5f605462054c3aa
Autor:
Giulia Maule, Antonio Casini, Claudia Montagna, Anabela S. Ramalho, Kris De Boeck, Zeger Debyser, Marianne S. Carlon, Gianluca Petris, Anna Cereseto
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Cystic fibrosis is caused by mutations in the CFTR chloride channel. Here, the authors develop a gene therapy approach using the programmable nuclease AsCas12a to correct a splicing mutation in CFTR, and show efficient repair of the mutation and reco
Externí odkaz:
https://doaj.org/article/d7c2cba4da6b42e3a01044d6646c73ee
Autor:
Annelotte M. Vonk, Peter van Mourik, Anabela S. Ramalho, Iris A.L. Silva, Marvin Statia, Evelien Kruisselbrink, Sylvia W.F. Suen, Johanna F. Dekkers, Frank P. Vleggaar, Roderick H.J. Houwen, Jasper Mullenders, Sylvia F. Boj, Robert Vries, Margarida D. Amaral, Kris de Boeck, Cornelis K. van der Ent, Jeffrey M. Beekman
Publikováno v:
STAR Protocols, Vol 1, Iss 1, Pp 100019- (2020)
Summary: This protocol describes the isolation, handling, culture of, and experiments with human colon stem cell organoids in the context of cystic fibrosis (CF). In human colon organoids, the function of cystic fibrosis transmembrane conductance reg
Externí odkaz:
https://doaj.org/article/fefd7bcad3ec46998e45178ebd7ffc13
Autor:
Lander Bosch, Barbara Bosch, Kris De Boeck, Tim Nawrot, Isabelle Meyts, Dominique Vanneste, Cleonice Alexandre Le Bourlegat, Julio Croda, Luiz Vicente Ribeiro Ferreira da Silva Filho
Publikováno v:
BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-8 (2017)
Abstract Background The reason why Cystic Fibrosis (CF) is the most common fatal genetic disease among Caucasians has been incompletely studied. We aimed at deepening the hypothesis that CF carriers have a relative protection against Mycobacterium tu
Externí odkaz:
https://doaj.org/article/cc12e51c81934f9f84b7698c5f44d545
Autor:
Joaquim Calvo-Lerma, Jessie Hulst, Mieke Boon, Carla Colombo, Etna Masip, Mar Ruperto, Victoria Fornés-Ferrer, Els van der Wiel, Ine Claes, Maria Garriga, Maria Roca, Paula Crespo-Escobar, Anna Bulfamante, Sandra Woodcock, Sandra Martínez-Barona, Ana Andrés, Kris de Boeck, Carmen Ribes-Koninckx, MyCyFAPP project
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213216 (2019)
BackgroundA method to adjust Pancreatic Enzyme Replacement Therapy in Cystic Fibrosis is not currently available.ObjectivesTo assess the in vivo efficacy of a method to adjust the dose of enzymatic supplement in CF extrapolated from previous in vitro
Externí odkaz:
https://doaj.org/article/1da370c90f1e4bf386f37d619d3a5f30
Autor:
Mieke Boon, Ine Claes, Trudy Havermans, Victoria Fornés-Ferrer, Joaquim Calvo-Lerma, Inês Asseiceira, Anna Bulfamante, María Garriga, Etna Masip, Sandra Woodcock, Sylvia Walet, Celeste Barreto, Carla Colombo, Paula Crespo, Els Van der Wiel, Jessie Hulst, Sandra Martinez-Barona, Rita Nobili, Luisa Pereira, Mar Ruperto, Saioa Vicente, Kris De Boeck, Carmen Ribes-Koninckx, MyCyFAPP consortium
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225004 (2019)
BackgroundMost patients with cystic fibrosis (CF) suffer from pancreatic insufficiency, leading to fat malabsorption, malnutrition and abdominal discomfort. Until recently, no specific tool was available for assessing gastro-intestinal related qualit
Externí odkaz:
https://doaj.org/article/fb2148c0128645daa4854213e6429b2e