Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Kris Sachsenmeier"'
Autor:
Philip East, Gavin P. Kelly, Dhruva Biswas, Michela Marani, David C. Hancock, Todd Creasy, Kris Sachsenmeier, Charles Swanton, TRACERx consortium, Julian Downward, Sophie de Carné Trécesson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Mutations in RAS oncogenes and related pathways are frequent in lung cancers. Here, the authors derive a RAS gene expression signature and a machine learning classifier to predict drug response and clinical outcomes in lung adenocarcinoma and other s
Externí odkaz:
https://doaj.org/article/e3cb67ca01f3408eabbb55aee891fb90
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-4 (2021)
Abstract If each cancer cell produces on average more than one cancer cell, we see a net growth of the tumors and metastases and vice versa. We review recent clinical results for microsatellite stable metastatic colorectal cancer (MSS-mCRC) suggestin
Externí odkaz:
https://doaj.org/article/aad00c2658df4d81a6211bcfe3643e3c
Autor:
Veronika Voronova, Kirill Peskov, Yuri Kosinsky, Gabriel Helmlinger, Lulu Chu, Alexandra Borodovsky, Richard Woessner, Kris Sachsenmeier, Wenlin Shao, Rakesh Kumar, Gayle Pouliot, Melinda Merchant, Holly Kimko, Ganesh Mugundu
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundAdenosine receptor type 2 (A2AR) inhibitor, AZD4635, has been shown to reduce immunosuppressive adenosine effects within the tumor microenvironment (TME) and to enhance the efficacy of checkpoint inhibitors across various syngeneic models.
Externí odkaz:
https://doaj.org/article/1a1c06171901426c87250762be86e987
Autor:
Dipti Vijayan, Deborah S. Barkauskas, Kimberley Stannard, Erin Sult, Rebecca Buonpane, Kazuyoshi Takeda, Michele W. L. Teng, Kris Sachsenmeier, Carl Hay, Mark J. Smyth
Publikováno v:
OncoImmunology, Vol 6, Iss 5 (2017)
The emerging role for CD73 in driving cancer growth and metastasis has presented opportunities to develop anti-CD73 monoclonal antibodies (mAbs) in the treatment of human cancers. Blockade of CD73 by antagonistic CD73 mAbs ameliorates tumor growth an
Externí odkaz:
https://doaj.org/article/0a7a800131af4075a4349dc86fb9039d
Autor:
Rich Woessner, Alexandra Borodovsky, Kris Sachsenmeier, Felix Scheuplein, Robert W. Wilkinson, Chaoyang Ye, Simon Dovedi
Publikováno v:
Animal Models for the Development of Cancer Immunotherapy. :11-62
Autor:
Kris Sachsenmeier, Johanna C. Bendell, Todd M. Bauer, J. Carl Barrett, Kelly Goodwin, Joshua Armenia, Deanna L. Russell, Melinda S. Merchant, Jonathan R. Dry, Manish R. Patel, Gerald Steven Falchook, Ben Sidders, Richard Woessner, Greg O'Connor, Pei Zhang, Robert McEwen, Gayle Pageau Pouliot, Alexandra Borodovsky, Bolan Linghu
Publikováno v:
Clinical Cancer Research. 26:2176-2187
Purpose:There are several agents in early clinical trials targeting components of the adenosine pathway including A2AR and CD73. The identification of cancers with a significant adenosine drive is critical to understand the potential for these molecu
Autor:
Tomas Ottosson, Rick Davies, Elisabeth Bäck, Lovisa Holmberg Schiavone, Mathias Uhlén, Johan Rockberg, Kris Sachsenmeier, Hanna Tegel, Mei Ding, Johan Brengdahl, Ulf Gehrmann, Lorenz M. Mayr, Björn Magnusson, Sophia Hober, Ida Isaksson, Rajneesh Malhotra, Aman Mebrahtu, Magnus Lundqvist, Douglas Ross-Thriepland
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Regulatory T cells (Tregs) are the key cells regulating peripheral autoreactive T lymphocytes. Tregs exert their function by suppressing effector T cells. Tregs have been shown to play essential roles in the control of a variety of physiological and
Autor:
Marco A. De Velasco, Yurie Kura, Naomi Ando, Noriko Sako, Kazuko Sakai, Alwin Schuller, Kris Sachsenmeier, Kazutoshi Fujita, Eri Banno, Masahiro Nozawa, Kazuhiro Yoshimura, Kazuto Nishio, Hirotsugu Uemura
Publikováno v:
Cancer Research. 82:5604-5604
Extracellular adenosine is an immunosuppressive molecule that is generated from ATP by the CD39 and CD73 ectoenzymes and exerts its antitumor effects through its interaction with the adenosine 2A receptor (A2AR) on immune cells. Approaches to curtail
Autor:
Sanjay Goel, Susanna Varkey Ulahannan, Anthony J. Olszanski, Patricia LoRusso, Rachel E. Sanborn, Sunil Sharma, Leisha A. Emens, Matthew Reilley, Victor Priego, Shuli Li, Bingxia Wang, Lixian Dong, Kris Sachsenmeier, John Gibbs, Robert Gharavi, Alonzo Martinez, Igor Proscurshim, Robert J. Fram, Alejandro Gomez-Pinillos, Drew W. Rasco
Publikováno v:
Journal of Clinical Oncology. 40:2506-2506
2506 Background: SUMOylation is a post-translational modification with a role in limiting type 1 interferon (IFN-1)-dependent immune responses. Subasumstat is a small-molecule inhibitor of SUMOylation with the potential to increase antitumor immunity
Autor:
Julian Downward, Philip East, Kris Sachsenmeier, Charles Swanton, Marani M, de Carné Trécesson S, David C. Hancock, Gavin Kelly, Dhruva Biswas, Creasy T
Activating mutations in the driver oncogene KRAS occur in 32% of lung adenocarcinomas, leading to more aggressive disease and resistance to therapy in preclinical studies. However, the association between KRAS mutational status and patient outcome or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c090f8e281184240c5841a3798337a3
https://doi.org/10.1101/2021.04.02.437896
https://doi.org/10.1101/2021.04.02.437896