Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kris Persaud"'
Autor:
Juqun Shen, Marie Danielle Vil, Marie Prewett, Chris Damoci, Haifan Zhang, Huiling Li, Xenia Jimenez, Dhanvanthri S. Deevi, Michelle Iacolina, Anthony Kayas, Rajiv Bassi, Kris Persaud, Anna Rohoza-Asandi, Paul Balderes, Nick Loizos, Dale L. Ludwig, James Tonra, Larry Witte, Zhenping Zhu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 6, Pp 594-604 (2009)
Platelet-derived growth factor receptor β (PDGFRβ) is upregulated in most of solid tumors. It is expressed by pericytes/smooth muscle cells, fibroblast, macrophage, and certain tumor cells. Several PDGF receptor-related antagonists are being develo
Externí odkaz:
https://doaj.org/article/2da6a13c5fe745ada07cc15c83ebd27c
Autor:
Yan Wu, Zhenping Zhu, Larry Witte, Dale L. Ludwig, Eric K. Rowinsky, Hagop Youssoufian, Jonathan D. Schwartz, Jacqueline Doody, Paul Balderes, Heather Griffith, Stanley Ng, David Surguladze, Su Wang, Douglas Burtrum, Kris Persaud, Gregory Liebisch, Marie Prewett, Xenia Jimenez, Rajiv Bassi, Michael Gregory, Carla Osborn, Desiree Policarpio, Kyla Driscoll Carroll, Zhaojing Zhong
Purpose: Transforming growth factor β (TGFβ) is a pleiotropic cytokine that affects tumor growth, metastasis, stroma, and immune response. We investigated the therapeutic efficacy of anti–TGFβ receptor II (TGFβ RII) antibody in controlling meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed416930b9e596a6b0a44e96f9185fb8
https://doi.org/10.1158/1078-0432.c.6518035
https://doi.org/10.1158/1078-0432.c.6518035
Autor:
Yan Wu, Zhenping Zhu, Larry Witte, Dale L. Ludwig, Eric K. Rowinsky, Hagop Youssoufian, Jonathan D. Schwartz, Jacqueline Doody, Paul Balderes, Heather Griffith, Stanley Ng, David Surguladze, Su Wang, Douglas Burtrum, Kris Persaud, Gregory Liebisch, Marie Prewett, Xenia Jimenez, Rajiv Bassi, Michael Gregory, Carla Osborn, Desiree Policarpio, Kyla Driscoll Carroll, Zhaojing Zhong
Supplementary Data from Anti–Transforming Growth Factor β Receptor II Antibody Has Therapeutic Efficacy against Primary Tumor Growth and Metastasis through Multieffects on Cancer, Stroma, and Immune Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5c80160db6520246cf82e53f23f3ca
https://doi.org/10.1158/1078-0432.22440745
https://doi.org/10.1158/1078-0432.22440745
Autor:
Kari Alitalo, Larry Witte, James R. Tonra, Kris Persaud, Daniel Hicklin, Philipp Steiner, Bronislaw Pytowski, Takashi Takahashi, Tanja Holopainen, Marika Waltari, Pirjo Laakkonen
Supplementary Table 1 from Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752d6bf670d7c51e551aa09cc3f2909b
https://doi.org/10.1158/0008-5472.22368315.v1
https://doi.org/10.1158/0008-5472.22368315.v1
Autor:
Kari Alitalo, Larry Witte, James R. Tonra, Kris Persaud, Daniel Hicklin, Philipp Steiner, Bronislaw Pytowski, Takashi Takahashi, Tanja Holopainen, Marika Waltari, Pirjo Laakkonen
Supplementary Figure 1 from Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9dd6b97d83007a10c2ca2fa5943c0f
https://doi.org/10.1158/0008-5472.22368318.v1
https://doi.org/10.1158/0008-5472.22368318.v1
Data from Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth
Autor:
Kari Alitalo, Larry Witte, James R. Tonra, Kris Persaud, Daniel Hicklin, Philipp Steiner, Bronislaw Pytowski, Takashi Takahashi, Tanja Holopainen, Marika Waltari, Pirjo Laakkonen
Vascular endothelial growth factor receptor 3 (VEGFR-3) binds VEGF-C and VEGF-D and is essential for the development of the lymphatic vasculature. Experimental tumors that overexpress VEGFR-3 ligands induce lymphatic vessel sprouting and enlargement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9236259721b89e344e7568877d8783c5
https://doi.org/10.1158/0008-5472.c.6495906.v1
https://doi.org/10.1158/0008-5472.c.6495906.v1
Autor:
David Surguladze, Kris Persaud, Douglas Burtrum, Sudhakar Chintharlapalli, Aiping Zhu, Marie Prewett, Sagit Hindi, Paul Balderes, Ruslan Novosyadlyy, Yun (Kenneth) Kang, Haifan Zhang, Scott W. Eastman, Juqun Shen, Yang Shen, Lin Zeng, Zhenping Zhu, Nicole Covino, Michael Topper, Marshall Snavely, Dale L. Ludwig, Andrew Ihor Korytko, Amelie Forest, Victor J. Wroblewski
Publikováno v:
mAbs
Bi-specific antibodies (BsAbs), which can simultaneously block 2 tumor targets, have emerged as promising therapeutic alternatives to combinations of individual monoclonal antibodies. Here, we describe the engineering and development of a novel, huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a00cbf92f1f1be13c3a0daff184b98
http://europepmc.org/articles/PMC4623440
http://europepmc.org/articles/PMC4623440
Autor:
Jacqueline Lypowy, Marshall Snavely, Kris Persaud, Amtul Bari, Wei Zhu, Zhiping Weng, Brian G. Pierce, Jaafar N. Haidar, Dale L. Ludwig, Xenia Luna
Publikováno v:
Journal of Molecular Biology. 426:1583-1599
Conformational entropy is an important component of protein-protein interactions; however, there is no reliable method for computing this parameter. We have developed a statistical measure of residual backbone entropy in folded proteins by using the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731d5bef4851739866c9019da078a93d
https://doi.org/10.1016/j.jmb.2013.12.024
https://doi.org/10.1016/j.jmb.2013.12.024
Autor:
Bo Qi, Julia Lee, Kris Persaud, Gregory W. Liebisch, Dale L. Ludwig, Nripen Singh, Michael Felo, Paul Balderes, James Hamzik, Behnam Shanehsaz, Stanley Ng, Yun Kenneth Kang
Publikováno v:
Biotechnology and Bioengineering
Recent advances in mammalian cell culture processes have significantly increased product titers, but have also resulted in substantial increases in cell density and cellular debris as well as process and product related impurities. As such, with impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dc787e7b06cf234f007f32c433dff4
https://doi.org/10.1002/bit.24969
https://doi.org/10.1002/bit.24969
Autor:
Dipa Patel, Qinwei Zhou, Aiping Zhu, Kris Persaud, Tim Blanc, Marshall Snavely, Dale L. Ludwig, Paul Balderes, Anthony Pennello, Yang Shen, David Surguladze, Yun Kenneth Kang, Stanley Ng, Lin Zeng, Sagit Hindi, Amtul Bari
Publikováno v:
mAbs
Optimization of biophysical properties is a critical success factor for the developability of monoclonal antibodies with potential therapeutic applications. The inter-domain disulfide bond between light chain (Lc) and heavy chain (Hc) in human IgG1 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7296d4ce2870870a44f9ba5969f517d8