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Akademický článek

Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins.

Autor: Hadrien Peyret, Annick Gehin, Eva C Thuenemann, Donatienne Blond, Aadil El Turabi, Lucy Beales, Dean Clarke, Robert J C Gilbert, Elizabeth E Fry, David I Stuart, Kris Holmes, Nicola J Stonehouse, Mike Whelan, William Rosenberg, George P Lomonossoff, David J Rowlands

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0120751 (2015)

The core protein of the hepatitis B virus, HBcAg, assembles into highly immunogenic virus-like particles (HBc VLPs) when expressed in a variety of heterologous systems. Specifically, the major insertion region (MIR) on the HBcAg protein allows the in

Externí odkaz: https://doaj.org/article/cdcbf7016b0e4ce982fd52851c55b055

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Reply to the Letter to the Editor in response to 'Role of autoantibody levels as biomarkers in the management of patients with myasthenia gravis: A systematic review and expert appraisal'

Autor: Andreas Meisel, Fulvio Baggi, Anthony Behin, Amelia Evoli, Anna Kostera‐Pruszczyk, Renato Mantegazza, Raul Juntas Morales, Anna Rostedt Punga, Sabrina Sacconi, Michael Schroeter, Jan Verschuuren, Louise Crathorne, Kris Holmes, Maria‐Isabel Leite

Publikováno v: European Journal of Neurology. 30:1162-1164

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e74137dc587cc30d110ae59bda7100d7
https://doi.org/10.1111/ene.15690

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Role of autoantibody levels as biomarkers in the management of patients with myasthenia gravis: A systematic review and expert appraisal

Publikováno v: European Journal of Neurology. WILEY
European Journal of Neurology

Background and purpose Although myasthenia gravis (MG) is recognized as an immunoglobulin G autoantibody-mediated disease, the relationship between autoantibody levels and disease activity in MG is unclear. We sought to evaluate this landscape throug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a53254e0a690d3cee02401ef352e32
http://hdl.handle.net/1887/3502246

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High-Risk Human Papillomavirus E5 Oncoprotein Displays Channel-Forming Activity Sensitive to Small-Molecule Inhibitors

Autor: Richard Foster, Mark Harris, Kris Holmes, Stephen Griffin, Gareth J. Howell, Nicola J. Stonehouse, Colin W. G. Fishwick, G. E. Blair, Laura Wetherill, Mark Verow, Marietta Müller, Andrew Macdonald

Publikováno v: Journal of Virology. 86:5341-5351

High-risk human papillomavirus type 16 (HPV16) is the primary causative agent of cervical cancer and therefore is responsible for significant morbidity and mortality worldwide. Cellular transformation is mediated directly by the expression of viral o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eafe84c374f15839ce986c3db84469e7
https://doi.org/10.1128/jvi.06243-11

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Assembly pathway of hepatitis B core virus-like particles from genetically fused dimers

Autor: M Whelan, David J. Rowlands, Alison E. Ashcroft, Kris Holmes, Nicola J. Stonehouse, Dale A. Shepherd

Publikováno v: The Journal of Biological Chemistry

Background: We studied assembly of HBV capsids using a genetically-fused dimer. Results: Assembly intermediates composed of two, three and five copies of a fused dimer have been isolated. Conclusion: Capsid assembly could progress using dimeric, trim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfc6ea62ce1df9e1e30fafa553a5b83

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Using Ion Mobility Spectrometry–Mass Spectrometry to Decipher the Conformational and Assembly Characteristics of the Hepatitis B Capsid Protein

Autor: David J. Rowlands, Kris Holmes, Dale A. Shepherd, Nicola J. Stonehouse, Alison E. Ashcroft

The structural and functional analysis of the core protein of hepatitis B virus is important for a full understanding of the viral life cycle and the development of novel therapeutic agents. The majority of the core protein (CP149) comprises the caps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0794c09f37b2db22858743804fbf55b3
https://europepmc.org/articles/PMC3762345/

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Création d’une police UNICODE

Autor: Kris Holmes, Charles A. Bigelow

Publikováno v: Cahiers GUTenberg. :81-102

The international scope of computing, digital information interchange, and electro- nic publishing has created a need for world-wide character encoding standards. UNICODE is a comprehensive standard designed to meet such a need. To be readable by hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d0ec35d5885243987e111f8c9547e01
https://doi.org/10.5802/cg.166

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Tandem Fusion of Hepatitis B Core Antigen Allows Assembly of Virus-Like Particles in Bacteria and Plants with Enhanced Capacity to Accommodate Foreign Proteins

Autor: Donatienne Blond, Elizabeth E. Fry, Aadil El Turabi, Dean Clarke, William Rosenberg, Lucy Beales, David J. Rowlands, Nicola J. Stonehouse, M Whelan, Hadrien Peyret, David I. Stuart, Robert J.C. Gilbert, Kris Holmes, Eva C. Thuenemann, George P. Lomonossoff, Annick Gehin

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0120751 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923504d17cf8d4154c25f4e4da55cd71
https://doi.org/10.1371/journal.pone.0120751

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