Study protocol: Whole genome sequencing Implementation in standard Diagnostics for Every cancer patient (WIDE)

Autor: Kris G. Samsom, Linda J. W. Bosch, Luuk J. Schipper, Paul Roepman, Ewart de Bruijn, Louisa R. Hoes, Immy Riethorst, Lieke Schoenmaker, Lizet E. van der Kolk, Valesca P. Retèl, Geert W. J. Frederix, Tineke E. Buffart, Jacobus J. M. van der Hoeven, Emile E. Voest, Edwin Cuppen, Kim Monkhorst, Gerrit A. Meijer

Publikováno v: BMC Medical Genomics, Vol 13, Iss 1, Pp 1-7 (2020)

Abstract Background ‘Precision oncology’ can ensure the best suitable treatment at the right time by tailoring treatment towards individual patient and comprehensive tumour characteristics. In current molecular pathology, diagnostic tests which a

Externí odkaz: https://doaj.org/article/b893dbefe1164ff4809d89051f9ba87d

RET Fluorescence In Situ Hybridization Analysis Is a Sensitive but Highly Unspecific Screening Method for RET Fusions in Lung Cancer

Autor: Paul Roepman, Danielle Cohen, Stephen P. Finn, Cathal O'Brien, Hein F.B.M. Sleddens, Kim Monkhorst, Karin Weijers, Guido M.J.M. Roemen, Isabelle C. Meijssen, Ernst-Jan M. Speel, Tom van Wezel, Winand N.M. Dinjens, Mirjam C. Boelens, H.J. Dubbink, Willemina R. R. Geurts-Giele, Jan H. von der Thüsen, Kris G. Samsom, Erik Thunnissen, Teodora Radonic

Publikováno v: Radonic, T, Geurts-Giele, W R R, Samsom, K G, Roemen, G M J M, von der Thüsen, J H, Thunnissen, E, Meijssen, I C, Sleddens, H F B M, Dinjens, W N M, Boelens, M C, Weijers, K, Speel, E J M, Finn, S P, O'Brien, C, van Wezel, T, Cohen, D, Monkhorst, K, Roepman, P & Dubbink, H J 2021, ' RET Fluorescence In Situ Hybridization Analysis Is a Sensitive but Highly Unspecific Screening Method for RET Fusions in Lung Cancer ', Journal of Thoracic Oncology, vol. 16, no. 5, pp. 798-806 . https://doi.org/10.1016/j.jtho.2021.01.1619
Journal of Thoracic Oncology, 16(5), 798-806. Elsevier Science
Journal of Thoracic Oncology, 16(5), 798-806. International Association for the Study of Lung Cancer

Introduction: RET gene fusions are established oncogenic drivers in 1% of NSCLC. Accurate detection of advanced patients with RET fusions is essential to ensure optimal therapy choice. We investigated the performance of fluorescence in situ hybridiza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1e428c89911a1ba266b62b3867f640
https://doi.org/10.1016/j.jtho.2021.01.1619

Molecular prognostic factors in small-intestinal neuroendocrine tumours

Autor: J.G. Van den Berg, M. R. Vriens, L. M. van Veenendaal, Kris G. Samsom, Gerlof D. Valk, Margot E T Tesselaar

Publikováno v: Endocrine Connections
Endocrine Connections, Vol 8, Iss 7, Pp 906-922 (2019)
Endocrine connections, 8(7), 906. BioScientifica Ltd.

Background Small-intestinal neuroendocrine tumours (SI-NETs) represent a heterogeneous group of rare tumours. In recent years, basic research in SI-NETs has attempted to unravel the molecular events underlying SI-NET tumorigenesis. Aim We aim to prov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abad49d55ee622c7a257e21ff0954ca5
http://europepmc.org/articles/PMC6599083

Clinical validation of Whole Genome Sequencing for cancer diagnostics

Autor: Edwin Cuppen, Stef van Lieshout, Hendrikus J. Dubbink, Paul Roepman, Marloes Steehouwer, Manon M. H. Huibers, Jacobus J.M. van der Hoeven, Kim Monkhorst, Lieke Schoenmaker, Willemina R. R. Geurts-Giele, Mariëtte E.G. Kranendonk, Bauke Ylstra, Mirjam C. Boelens, Floris H. Groenendijk, Alexander Hoischen, Wendy W.J. de Leng, Ewart de Bruijn, Margaretha G. M. Roemer, Kris G. Samsom

Publikováno v: Roepman, P, de Bruijn, E, van Lieshout, S, Schoenmaker, L, Boelens, M C, Dubbink, H J, Geurts-Giele, W R R, Groenendijk, F H, Huibers, M M H, Kranendonk, M E G, Roemer, M G M, Samsom, K G, Steehouwer, M, de Leng, W W J, Hoischen, A, Ylstra, B, Monkhorst, K, van der Hoeven, J J M & Cuppen, E 2021, ' Clinical Validation of Whole Genome Sequencing for Cancer Diagnostics ', Journal of Molecular Diagnostics, vol. 23, no. 7, pp. 816-833 . https://doi.org/10.1016/j.jmoldx.2021.04.011
Journal of Molecular Diagnostics, 23, 7, pp. 816-833
Journal of Molecular Diagnostics, 23, 816-833
Journal of Molecular Diagnostics, 23(7), 816-833. Association of Molecular Pathology

Whole genome sequencing (WGS) using fresh frozen tissue and matched blood samples from cancer patients is becoming in reach as the most complete genetic tumor test. With a trend towards the availability of small biopsies and the need to screen an inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e77afd0b0074d49a789ea249d925a6
https://doi.org/10.1101/2020.10.29.20222091

Driver mutations occur frequently in metastases of well-differentiated small intestine neuroendocrine tumours

Autor: Gerlof D. Valk, Margot E T Tesselaar, Koert F. D. Kuhlmann, Gerrit A. Meijer, Paul Roepman, M Wouter Dercksen, José G van den Berg, Kris G. Samsom, Liudmila L. Kodach, Sonja Levy, Wieke H M Verbeek, Neeltje Steeghs, Linde M. van Veenendaal

Publikováno v: HistopathologyReferences. 78(4)

Aims To investigate the clinicopathological significance of driver mutations in metastatic well-differentiated small intestine neuroendocrine tumours (SI-NETs). Methods and results Whole genome sequencing (WGS) of 35 metastatic SI-NETs and next-gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9280554e242d09c4eb4e1881ec459b95
https://pubmed.ncbi.nlm.nih.gov/32931025