Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Kris C, Wood"'
Autor:
Daniel P. Nussbaum, Colin A. Martz, Andrew M. Waters, Alejandro Barrera, Annie Liu, Justine C. Rutter, Christian G. Cerda-Smith, Amy E. Stewart, Chao Wu, Merve Cakir, Cecilia B. Levandowski, David E. Kantrowitz, Shannon J. McCall, Mariaelena Pierobon, Emanuel F. Petricoin, J. Joshua Smith, Timothy E. Reddy, Channing J. Der, Dylan J. Taatjes, Kris C. Wood
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produc
Externí odkaz:
https://doaj.org/article/f640317b562445dfa0b4f3772b68e0d1
Autor:
Shane T. Killarney, Rachel Washart, Ryan S. Soderquist, Jacob P. Hoj, Jamie Lebhar, Kevin H. Lin, Kris C. Wood
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
During apoptosis, mitochondrial outer membrane permeabilization results in cytosolic mitochondrial RNA (mtRNA). Here, the authors demonstrate that caspase-3/7 inhibition promotes a cytosolic mtRNA-driven Type I interferon response via MDA5/MAVS/IRF3,
Externí odkaz:
https://doaj.org/article/94021e96acd04ecf873c4eec58ea4e06
Autor:
Michael E. Lidsky, Zechen Wang, Min Lu, Annie Liu, S. David Hsu, Shannon J. McCall, Zhecheng Sheng, Joshua A. Granek, Kouros Owzar, Karen S. Anderson, Kris C. Wood
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-17 (2022)
Abstract Intrahepatic cholangiocarcinoma (ICC) remains a deadly malignancy lacking systemic therapies for advanced disease. Recent advancements include selective FGFR1–3 inhibitors for the 15% of ICC patients harboring fusions, although survival is
Externí odkaz:
https://doaj.org/article/29a0da3b66f341b28c0bd50b407a1e68
Autor:
Daniel Y. Joh, Jacob T. Heggestad, Shengwei Zhang, Grace R. Anderson, Jayanta Bhattacharyya, Suzanne E. Wardell, Simone A. Wall, Amy B. Cheng, Faris Albarghouthi, Jason Liu, Sachi Oshima, Angus M. Hucknall, Terry Hyslop, Allison H. S. Hall, Kris C. Wood, E. Shelley Hwang, Kyle C. Strickland, Qingshan Wei, Ashutosh Chilkoti
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract Management of breast cancer in limited-resource settings is hindered by a lack of low-cost, logistically sustainable approaches toward molecular and cellular diagnostic pathology services that are needed to guide therapy. To address these li
Externí odkaz:
https://doaj.org/article/dbe9959994e64aa882ef7c71873c21a5
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 12 (2022)
Wnt signaling regulates the balance between stemness and differentiation in multiple tissues and in cancer. RNF43-mutant pancreatic cancers are dependent on Wnt production, and pharmacologic blockade of the pathway, e.g., by PORCN inhibitors, leads t
Externí odkaz:
https://doaj.org/article/d3ac6d2f47d54c30923a44bed4508295
Publikováno v:
MethodsX, Vol 9, Iss , Pp 101927- (2022)
PTEN is a well-known tumor suppressor that is inactivated or suppressed at a high frequency in cancer. We sought an assay to screen compounds for ones that differentially inhibited proliferation or induced cytotoxicity in PTEN mutated cancer cells. W
Externí odkaz:
https://doaj.org/article/d4ebe48383f1404f8517558a0620731e
Autor:
Kris C. Wood
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-3 (2020)
Two complementary studies in Nature Communications define a critical role for the anti-apoptotic protein MCL-1 as a driver of adaptive survival in tumor cells treated with oncogene targeted therapies, providing a rationale for combining these agents
Externí odkaz:
https://doaj.org/article/b3104b61e16b45ff87d587459438569d
Autor:
Kristopher A. Sarosiek, Kris C. Wood
Publikováno v:
Trends in Cancer. 9:96-110
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c0f1e40b36221d4a49393c5672d33b7
https://doi.org/10.1016/j.trecan.2022.10.004
https://doi.org/10.1016/j.trecan.2022.10.004
Autor:
Irem Ozkan-Dagliyan, J. Nathaniel Diehl, Samuel D. George, Antje Schaefer, Bjoern Papke, Kathleen Klotz-Noack, Andrew M. Waters, Craig M. Goodwin, Prson Gautam, Mariaelena Pierobon, Sen Peng, Thomas S.K. Gilbert, Kevin H. Lin, Onur Dagliyan, Krister Wennerberg, Emanuel F. Petricoin, III, Nhan L. Tran, Shripad V. Bhagwat, Ramon V. Tiu, Sheng-Bin Peng, Laura E. Herring, Lee M. Graves, Christine Sers, Kris C. Wood, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107764- (2020)
Summary: We address whether combinations with a pan-RAF inhibitor (RAFi) would be effective in KRAS mutant pancreatic ductal adenocarcinoma (PDAC). Chemical library and CRISPR genetic screens identify combinations causing apoptotic anti-tumor activit
Externí odkaz:
https://doaj.org/article/5756388e183142489ccb4823f8985e8f
Autor:
Yi Ding, Chang Gong, De Huang, Rui Chen, Pinpin Sui, Kevin H. Lin, Gehao Liang, Lifeng Yuan, Handan Xiang, Junying Chen, Tao Yin, Peter B. Alexander, Qian-Fei Wang, Er-Wei Song, Qi-Jing Li, Kris C. Wood, Xiao-Fan Wang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Resistance to anti-HER2 therapy in breast cancer remains a major obstacle in the clinic. Here the authors performed a CRISPR-selective vulnerability screen to identify transaldoloase as a target that is synthetically lethal with HER2 inhibition in br
Externí odkaz:
https://doaj.org/article/3b4653d4e9534695875c3adfe802cb21