Supplementary Figure 2 from Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab

Autor: Niels W.C.J. van de Donk, Tuna Mutis, A. Kate Sasser, Henk M. Lokhorst, Torben Plesner, Christopher Chiu, Richard W.J. Groen, Pino J. Poddighe, René J.P. Musters, Johan van Meerloo, Sonja Zweegman, Marloes E.C. Broekmans, Andries C. Bloem, Jeroen F. van Velzen, Berris van Kessel, Inger S. Nijhof, Kris A. Frerichs, Jakub Krejcik

Daratumumab-mediated CD38 reduction of MM cells in the presence of PBMCs as shown by Western blot analysis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058adc8564febc80f981da9e7692cc1e
https://doi.org/10.1158/1078-0432.22462586.v1

Supplementary Figure 5 from Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab

Autor: Niels W.C.J. van de Donk, Tuna Mutis, A. Kate Sasser, Henk M. Lokhorst, Torben Plesner, Christopher Chiu, Richard W.J. Groen, Pino J. Poddighe, René J.P. Musters, Johan van Meerloo, Sonja Zweegman, Marloes E.C. Broekmans, Andries C. Bloem, Jeroen F. van Velzen, Berris van Kessel, Inger S. Nijhof, Kris A. Frerichs, Jakub Krejcik

Monocytes take up AF488-labeled daratumumab-CD38 complexes from PKH-26-stained UM9 cells.

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https://doi.org/10.1158/1078-0432.22462577.v1

Data from Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab

Autor: Niels W.C.J. van de Donk, Tuna Mutis, A. Kate Sasser, Henk M. Lokhorst, Torben Plesner, Christopher Chiu, Richard W.J. Groen, Pino J. Poddighe, René J.P. Musters, Johan van Meerloo, Sonja Zweegman, Marloes E.C. Broekmans, Andries C. Bloem, Jeroen F. van Velzen, Berris van Kessel, Inger S. Nijhof, Kris A. Frerichs, Jakub Krejcik

Purpose: Daratumumab treatment results in a marked reduction of CD38 expression on multiple myeloma cells. The aim of this study was to investigate the clinical implications and the underlying mechanisms of daratumumab-mediated CD38 reduction.Experim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc1ec2ca3e37165483ff0af7857d0b2
https://doi.org/10.1158/1078-0432.c.6525140

Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab

Autor: Torben Plesner, René J. P. Musters, Berris van Kessel, Jeroen F. van Velzen, A. Kate Sasser, Pino J. Poddighe, Marloes E.C. Broekmans, Tuna Mutis, Inger S. Nijhof, Henk M. Lokhorst, Jakub Krejcik, Richard W.J. Groen, Kris A. Frerichs, Sonja Zweegman, Niels W.C.J. van de Donk, Andries C. Bloem, Johan van Meerloo, Christopher Chiu

Publikováno v: Krejcik, J, Frerichs, K A, Nijhof, I S, van Kessel, B, van Velzen, J, Bloem, A C, Broekmans, M, Zweegman, S, van Meerloo, J, Musters, R J, Poddighe, P, Groen, R, Chiu, C, Plesner, T, Lokhorst, H M, Sasser, A K, Mutis, T & van de Donk, N W C J 2017, ' Monocytes and granulocytes reduce CD38 expression levels on myeloma cells in patients treated with daratumumab ', Clinical Cancer Research, vol. 23, no. 24, pp. 7498-7511 . https://doi.org/10.1158/1078-0432.CCR-17-2027
Krejcik, J, Frerichs, K A, Nijhof, I S, van Kessel, B, van Velzen, J F, Bloem, A C, Broekmans, M E C, Zweegman, S, van Meerloo, J, Musters, R J P, Poddighe, P J, Groen, R W J, Chiu, C, Plesner, T, Lokhorst, H M, Sasser, A K, Mutis, T & van de Donk, N W C J 2017, ' Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab ', Clinical Cancer Research, vol. 23, no. 24, pp. 7498-7511 . https://doi.org/10.1158/1078-0432.CCR-17-2027
Clinical Cancer Research, 23(24), 7498-7511. American Association for Cancer Research Inc.

Purpose: Daratumumab treatment results in a marked reduction of CD38 expression on multiple myeloma cells. The aim of this study was to investigate the clinical implications and the underlying mechanisms of daratumumab-mediated CD38 reduction. Experi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a411b4972ab21d4db661d3cca064dd68
https://doi.org/10.1158/1078-0432.ccr-17-2027