Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kripa S. Keyan"'
Autor:
Omar M. Khan, Jorge Almagro, Jessica K. Nelson, Stuart Horswell, Vesela Encheva, Kripa S. Keyan, Bruce E. Clurman, Ambrosius P. Snijders, Axel Behrens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The tumor suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF) and itself a target for ubiquitylation. Here, the authors show that TRIP12 mediates branched K11-linked ubiquitylation of FBW7, to regulate its
Externí odkaz:
https://doaj.org/article/6e27448b8929476da30da600acc41eb2
Autor:
Kripa S Keyan, Safa Salim, Swetha Gowda, Doua Abdelrahman, Syeda Sakina Amir, Zeyaul Islam, Claire Vargas, Maria Teresa Bengoechea-Alonso, Amira Alwa, Subrat Dahal, Prasanna R. Kolatkar, Sahar Da’as, Jerome Torrisani, Johan Ericsson, Farhan Mohammad, Omar M Khan
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-17 (2023)
Abstract Transforming growth factor β (TGFβ) pathway is a master regulator of cell proliferation, differentiation, and death. Deregulation of TGFβ signalling is well established in several human diseases including autoimmune disorders and cancer.
Externí odkaz:
https://doaj.org/article/a71608c382a4486081a5585fd2c895d0
Autor:
Kripa S. Keyan, Jorge Almagro, Bruce E. Clurman, Ambrosius P. Snijders, Stuart Horswell, Vesela Encheva, Jessica K. Nelson, Axel Behrens, Omar M. Khan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are commonly downregulated in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52317b9d43255e960ff3720013d3922f
https://doaj.org/article/6e27448b8929476da30da600acc41eb2
https://doaj.org/article/6e27448b8929476da30da600acc41eb2
Publikováno v:
Cancers; Volume 15; Issue 2; Pages: 505
Chemotherapy resistance is a major hurdle in cancer treatment. Taxol-based chemotherapy is widely used in the treatment of cancers including breast, ovarian, and pancreatic cancer. Loss of function of the tumor suppressor F-box WD-40 domain containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41848d176b058e6e65ce6872e66a78b
https://doi.org/10.3390/cancers15020505
https://doi.org/10.3390/cancers15020505
Publikováno v:
Journal of Biomedical Materials Research Part B: Applied Biomaterials. 104:771-781
In this study, platelet-rich plasma (PRP) was incorporated into gelatin-nanohydroxyapatite fibrous scaffold in two forms (PRP gel as coating on the scaffold [PCSC] and PRP powder within the scaffold [PCSL] and investigated for (a) growth factor relea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eaafc4b8f668ded2ab11ac2b1471d28
https://doi.org/10.1002/jbm.b.33605
https://doi.org/10.1002/jbm.b.33605
Publikováno v:
International Journal of Bioscience, Biochemistry and Bioinformatics. :58-62
Our aim wa s to investigate the adverse effects of occupational exposure to trivalent chromium in tannery workers and unexposed persons. Trivalent chromium used in tanning industry is an environmental contaminant that acts as a carcinogen towards hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5598b21ebd398eb37843fd5a4fefd59
https://doi.org/10.7763/ijbbb.2011.v1.11
https://doi.org/10.7763/ijbbb.2011.v1.11
Publikováno v:
Journal of biomedical materials research. Part B, Applied biomaterials. 104(4)
In this study, platelet-rich plasma (PRP) was incorporated into gelatin-nanohydroxyapatite fibrous scaffold in two forms (PRP gel as coating on the scaffold [PCSC] and PRP powder within the scaffold [PCSL] and investigated for (a) growth factor relea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2abb0a1e0cf69dfce86e29a03dc5c4a5
https://pubmed.ncbi.nlm.nih.gov/26821772
https://pubmed.ncbi.nlm.nih.gov/26821772
Publikováno v:
Colloids and surfaces. B, Biointerfaces. 136
Intervertebral disc degeneration, occurring mainly in nucleus pulposus (NP), is a leading cause of low back pain. In seeking to mitigate this condition, investigators in the field of NP tissue engineering have increasingly studied the use of hydrogel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2cd1421b8520660d768a725f1ace106
https://pubmed.ncbi.nlm.nih.gov/26363270
https://pubmed.ncbi.nlm.nih.gov/26363270
Publikováno v:
Asian Pacific journal of cancer prevention : APJCP. 12(3)
Road pavement workers are exposed to many known carcinogens in their complex occupational environment. The study makes an attempt to investigate exposure to polycyclic aromatic hydrocarbons (PAH) from the bitumen fumes among the road pavement workers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b826d6aed2093f28226078fa3e244529
https://pubmed.ncbi.nlm.nih.gov/21627370
https://pubmed.ncbi.nlm.nih.gov/21627370
Publikováno v:
Asian Pacific journal of cancer prevention : APJCP. 12(1)
In India the incidence of breast cancer is on the rise and it is rapidly becoming the number one cancer in females, pushing cervical cancer to the second spot. The contribution of BRCA2 to the development of the sporadic form of breast cancer remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::954d7d4ccb978e9ea2a3babed961076b
https://pubmed.ncbi.nlm.nih.gov/21517277
https://pubmed.ncbi.nlm.nih.gov/21517277