A Benzenesulfonamide-Based Mitochondrial Uncoupler Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Epithelial Ovarian Cancer.

Autor: Bi F; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.; Sheng Jing Hospital of China Medical University, Shenyang, Liaoning, China., Jiang Z; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.; The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Park W; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.; Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, Texas., Hartwich TMP; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut., Ge Z; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.; The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Chong KY; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut., Yang K; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut., Morrison MJ; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut., Kim D; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma., Kim J; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana University Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana., Zhang W; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky.; Lucille Parker Markey Cancer Center, University of Kentucky Health Care, Lexington, Kentucky., Kril LM; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky.; Lucille Parker Markey Cancer Center, University of Kentucky Health Care, Lexington, Kentucky.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky., Watt DS; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky.; Lucille Parker Markey Cancer Center, University of Kentucky Health Care, Lexington, Kentucky.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky., Liu C; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky. yang.yang@yale.edu chunming.liu@uky.edu.; Lucille Parker Markey Cancer Center, University of Kentucky Health Care, Lexington, Kentucky., Yang-Hartwich Y; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut. yang.yang@yale.edu chunming.liu@uky.edu.; Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2021 Dec; Vol. 20 (12), pp. 2398-2409. Date of Electronic Publication: 2021 Oct 08.

Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents.

Autor: Hammill JT; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Sviripa VM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0596, United States.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536-0093, United States., Kril LM; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0596, United States.; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0509, United States., Ortiz D; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, United States., Fargo CM; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, United States., Kim HS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Chen Y; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Rector J; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Rice AL; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Domagalska MA; Department of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat, 155, Antwerpen 2000, Belgium., Begley KL; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0596, United States.; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0509, United States., Liu C; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536-0093, United States.; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0509, United States., Rangnekar VM; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536-0093, United States.; Department of Radiation Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky 40506-9983, United States.; Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0305, United States., Dujardin JC; Department of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat, 155, Antwerpen 2000, Belgium., Watt DS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0596, United States.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536-0093, United States.; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0509, United States., Landfear SM; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, United States., Guy RK; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Aug 26; Vol. 64 (16), pp. 12152-12162. Date of Electronic Publication: 2021 Aug 06.

Mitochondrial uncoupling and the disruption of the metabolic network in hepatocellular carcinoma.

Autor: Turcios L; Department of Surgery, Transplant Division, College of Medicine, University of Kentucky, Lexington, KY, USA., Marti F; Department of Surgery, Transplant Division, College of Medicine, University of Kentucky, Lexington, KY, USA., Watt DS; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA.; Lucillle Parker Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY, USA., Kril LM; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA.; Lucillle Parker Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY, USA., Khurana A; Lucillle Parker Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY, USA.; Department of Radiology, College of Medicine, University of Kentucky, Lexington, KY, USA., Chapelin F; Lucillle Parker Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY, USA.; Department of Biomedical Engineering, College of Medicine, University of Kentucky, Lexington, KY, USA., Liu C; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA.; Lucillle Parker Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY, USA., Zwischenberger JB; Department of Surgery, Transplant Division, College of Medicine, University of Kentucky, Lexington, KY, USA.; Lucillle Parker Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY, USA., Evers BM; Lucillle Parker Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY, USA., Gedaly R; Department of Surgery, Transplant Division, College of Medicine, University of Kentucky, Lexington, KY, USA.; Lucillle Parker Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY, USA.

Publikováno v: Oncotarget [Oncotarget] 2020 Aug 04; Vol. 11 (31), pp. 3013-3024. Date of Electronic Publication: 2020 Aug 04 (Print Publication: 2020).

Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish.

Autor: Xie Y; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Kril LM; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Yu T; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA., Zhang W; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA., Frasinyuk MS; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA.; Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, Kyiv, 02094, Ukraine., Bondarenko SP; National University of Food Technologies, Kyiv, 01601, Ukraine., Kondratyuk KM; Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, Kyiv, 02094, Ukraine., Hausman E; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA., Martin ZM; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Wyrebek PP; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Liu X; Center for Drug Innovation and Discovery, Hebei Normal University, Shijiazhuang, Hebei, 050024, People's Republic of China., Deaciuc A; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Dwoskin LP; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Chen J; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA., Zhu H; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA., Zhan CG; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA.; Molecular Modeling and Pharmaceutical Center, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Sviripa VM; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA., Blackburn J; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA., Watt DS; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA. dwatt@uky.edu.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA. dwatt@uky.edu.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA. dwatt@uky.edu.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40536-0596, USA. dwatt@uky.edu., Liu C; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, 40536-0509, USA. chunming.liu@uky.edu.; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0093, USA. chunming.liu@uky.edu.

Publikováno v: Scientific reports [Sci Rep] 2019 Apr 23; Vol. 9 (1), pp. 6439. Date of Electronic Publication: 2019 Apr 23.

Bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones: New classes of antibacterial/antifungal agents.

Autor: Shrestha SK; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536-0596, USA., Kril LM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536-0596, USA; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536-0509, USA., Green KD; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536-0596, USA., Kwiatkowski S; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536-0509, USA; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY 40536-0093, USA., Sviripa VM; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536-0509, USA; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, USA., Nickell JR; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536-0596, USA., Dwoskin LP; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536-0596, USA., Watt DS; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536-0509, USA; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, USA; Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY 40536-0093, USA. Electronic address: dwatt@uky.edu., Garneau-Tsodikova S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536-0596, USA. Electronic address: sylviegtsodikova@uky.edu.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2017 Jan 01; Vol. 25 (1), pp. 58-66. Date of Electronic Publication: 2016 Oct 10.