Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action

Autor: Thomas, Dierk, Hammerling, Bettina C, Wu, Kezhong, Wimmer, Anna-Britt, Ficker, Eckhard K, Kirsch, Glenn E, Kochan, Mary C, Wible, Barbara A, Scholz, Eberhard P, Zitron, Edgar, Kathöfer, Sven, Kreye, Volker A W, Katus, Hugo A, Schoels, Wolfgang, Karle, Christoph A, Kiehn, Johann

1 The topoisomerase II inhibitor amsacrine is used in the treatment of acute myelogenous leukemia. Although most anticancer drugs are believed not to cause acquired long QT syndrome (LQTS), concerns have been raised by reports of QT interval prolonga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3831d7bb98211434e333c7372fc7d864
https://europepmc.org/articles/PMC1574964/

Regulation of cardiac inwardly rectifying potassium current I K1 and Kir2. x channels by endothelin-1.

Autor: Kiesecker, Claudia, Zitron, Edgar, Scherer, Daniel, Lueck, Sonja, Bloehs, Ramona, Scholz, Eberhard, Pirot, Marcus, Kathöfer, Sven, Thomas, Dierk, Kreye, Volker A. W., Kiehn, Johann, Borst, Mathias M., Katus, Hugo A., Schoels, Wolfgang, Karle, Christoph A.

Publikováno v: Journal of Molecular Medicine; Jan2006, Vol. 84 Issue 1, p46-56, 11p, 1 Black and White Photograph, 1 Diagram, 6 Graphs

Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by a1A-adrenoceptors.

Autor: Thomas, Dierk, Wu, Kezhong, Wimmer, Anna-Britt, Zitron, Edgar, Hammerling, Bettina, Kathöfer, Sven, Lueck, Sonja, Bloehs, Ramona, Kreye, Volker, Kiehn, Johann, Katus, Hugo, Schoels, Wolfgang, Karle, Christoph

Publikováno v: Journal of Molecular Medicine; Dec2004, Vol. 82 Issue 12, p826-837, 12p

Human cardiac inwardly rectifying current IKir2.2 is upregulated by activation of protein kinase A

Autor: Zitron, Edgar, Kiesecker, Claudia, Lück, Sonja, Kathöfer, Sven, Thomas, Dierk, Kreye, Volker A.W., Kiehn, Johann, Katus, Hugo A., Schoels, Wolfgang, Karle, Christoph A.

Publikováno v: Cardiovascular Research; Aug2004, Vol. 63 Issue 3, p520-527, 8p

Hypoxia-induced inhibition of whole cell membrane currents and ion transport of A549 cells.

Autor: Karle, Christoph, Gehrig, Tobias, Wodopia, Ralf, Höschele, Sabine, Kreye, Volker A. W., Katus, Hugo A., Bärtsch, Peter, Mairbäurl, Heimo

Publikováno v: American Journal of Physiology: Lung Cellular & Molecular Physiology; Jun2004, Vol. 30 Issue 6, pL1154-L1160, 7p, 1 Diagram, 1 Chart, 7 Graphs