Determination of the physiological and pathological roles of E2F3 in adult tissues

Autor: Gamper, I, Burkhart, DL, Bywater, MB, Garcia, D, Wilson, CH, Kreuzaler, PA, Arends, MJ, Zheng, YW, Perfetto, A, Littlewood, TD, Evan, GI

Publikováno v: Gamper, I, Burkhart, D L, Bywater, M J, Garcia, D, Wilson, C H, A. Kreuzaler, P, Arends, M, Zheng, Y-W, Perfetto, A, Littlewood, T D & Evan, G I 2017, ' Determination of the physiological and pathological roles of E2F3 in adult tissues ', Scientific Reports . https://doi.org/10.1038/s41598-017-09494-6
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

While genetically engineered mice have made an enormous contribution towards the elucidation of human disease, it has hitherto not been possible to tune up or down the level of expression of any endogenous gene. Here we describe compound genetically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cec54f61708aea56f8d3504189bd885
https://www.repository.cam.ac.uk/handle/1810/267477

Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi.

Autor: Parker A; Gut Health and Food Safety Research Programme, Institute of Food Research, Norwich, United Kingdom., Maclaren OJ; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom., Fletcher AG; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom.; School of Mathematics and Statistics, University of Sheffield, Sheffield, United Kingdom.; Bateson Centre, University of Sheffield, Sheffield, United Kingdom., Muraro D; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom., Kreuzaler PA; Department of Biochemistry, University of Cambridge, United Kingdom; and., Byrne HM; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom., Maini PK; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom., Watson AJ; Norwich Medical School, University of East Anglia, Norwich, United Kingdom., Pin C; Gut Health and Food Safety Research Programme, Institute of Food Research, Norwich, United Kingdom; carmen.pin@ifr.ac.uk.

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The PI3K regulatory subunits p55α and p50α regulate cell death in vivo.

Autor: Pensa S; Department of Pathology, University of Cambridge, Cambridge, UK., Neoh K; Department of Pathology, University of Cambridge, Cambridge, UK., Resemann HK; Department of Pathology, University of Cambridge, Cambridge, UK., Kreuzaler PA; 1] Department of Pathology, University of Cambridge, Cambridge, UK [2] Department of Biochemistry, University of Cambridge, Cambridge, UK., Abell K; 1] Department of Pathology, University of Cambridge, Cambridge, UK [2] LEO Pharma A/S Industriparken 55, Ballerup, Denmark., Clarke NJ; GlaxoSmithKline, Stevenage, UK., Reinheckel T; Institute of Molecular Medicine and Cell Research and BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Freiburg, Germany., Kahn CR; Joslin Diabetes Center, Boston, MA, USA., Watson CJ; Department of Pathology, University of Cambridge, Cambridge, UK.

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Stat3 controls lysosomal-mediated cell death in vivo.

Autor: Kreuzaler PA; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK., Staniszewska AD, Li W, Omidvar N, Kedjouar B, Turkson J, Poli V, Flavell RA, Clarkson RW, Watson CJ

Publikováno v: Nature cell biology [Nat Cell Biol] 2011 Mar; Vol. 13 (3), pp. 303-9. Date of Electronic Publication: 2011 Feb 20.

The role of cathepsins in involution and breast cancer.

Autor: Watson CJ; Department of Pathology, University of Cambridge, Cambridge, MA, USA. cjw53@cam.ac.uk, Kreuzaler PA

Publikováno v: Journal of mammary gland biology and neoplasia [J Mammary Gland Biol Neoplasia] 2009 Jun; Vol. 14 (2), pp. 171-9. Date of Electronic Publication: 2009 May 13.