The epithelial-specific ER stress sensor ERN2/IRE1β enables host-microbiota crosstalk to affect colon goblet cell development.

Autor: Grey MJ; Division of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.; Harvard Digestive Disease Center, Boston Children's Hospital, Boston, Massachusetts, USA., De Luca H; Division of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA., Ward DV; Department of Microbiology and Physiological Systems, and.; Program in Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Kreulen IA; Division of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA., Bugda Gwilt K; Division of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA., Foley SE; Department of Microbiology and Physiological Systems, and.; Program in Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Thiagarajah JR; Division of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.; Harvard Digestive Disease Center, Boston Children's Hospital, Boston, Massachusetts, USA., McCormick BA; Department of Microbiology and Physiological Systems, and.; Program in Microbiome Dynamics, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Turner JR; Harvard Digestive Disease Center, Boston Children's Hospital, Boston, Massachusetts, USA.; Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Departments of Pathology and Medicine, Harvard Medical School, Boston, Massachusetts, USA., Lencer WI; Division of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.; Harvard Digestive Disease Center, Boston Children's Hospital, Boston, Massachusetts, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2022 Sep 01; Vol. 132 (17). Date of Electronic Publication: 2022 Sep 01.