PKD2 regulates autophagy and forms a protein complex with BECN1 at the primary cilium of hypothalamic neuronal cells.

Autor: García-Navarrete C; Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile., Kretschmar C; Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile., Toledo J; Advanced Scientific Equipment Network (REDECA), Facultad de Medicina, Universidad de Chile, Chile., Gutiérrez K; Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile., Hernández-Cáceres MP; Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile; Department of Basic Sciences, Faculty of Medicine and Sciences, Universidad San Sebastián, Santiago, Chile., Budini M; Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile; Autophagy Research Center, Santiago, Chile., Parra V; Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas & Farmacéuticas, Universidad de Chile, Santiago, Chile; Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas & Facultad Medicina, Universidad de Chile, Santiago, Chile., Burgos PV; Autophagy Research Center, Santiago, Chile; Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida Del Valle Norte #725, Huechuraba 8580702, Santiago, Chile., Lavandero S; Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas & Farmacéuticas, Universidad de Chile, Santiago, Chile; Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas & Facultad Medicina, Universidad de Chile, Santiago, Chile; Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States., Morselli E; Department of Basic Sciences, Faculty of Medicine and Sciences, Universidad San Sebastián, Santiago, Chile; Autophagy Research Center, Santiago, Chile., Peña-Oyarzún D; Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile; Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas & Facultad Medicina, Universidad de Chile, Santiago, Chile; Faculty of Odontology and Rehabilitation Sciences, Universidad San Sebastián, Chile. Electronic address: daniel.pena@uss.cl., Criollo A; Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile; Autophagy Research Center, Santiago, Chile; Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas & Facultad Medicina, Universidad de Chile, Santiago, Chile. Electronic address: alcriollo@u.uchile.cl.

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Aug; Vol. 1870 (6), pp. 167256. Date of Electronic Publication: 2024 May 21.

Inhibition of PORCN Blocks Wnt Signaling to Attenuate Progression of Oral Carcinogenesis.

Autor: Peña-Oyarzún D; Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.; Physiology Department, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.; Interdisciplinary Center for Research in Territorial Health of the Aconcagua Valley (CIISTe Aconcagua), School of Medicine, Faculty of Medicine, San Felipe Campus, Universidad de Valparaiso, Chile., Flores T; Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.; Research Centre in Dental Science (CICO), Faculty of Dentistry, Universidad de La Frontera, Temuco, Chile.; Department of Pathology and Oral Medicine, Faculty of Dentistry, Universidad de Chile, Santiago, Chile., Torres VA; Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences and Faculty of Medicine, Universidad de Chile, Santiago, Chile.; Millennium Institute on Immunology and Immunotherapy, Universidad de Chile, Santiago, Chile., Quest AFG; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences and Faculty of Medicine, Universidad de Chile, Santiago, Chile.; Laboratory of Cellular Communication, Center for studies on Exercise, Metabolism and Cancer (CEMC), Faculty of Medicine, Universidad de Chile, Santiago, Chile., Lobos-González L; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences and Faculty of Medicine, Universidad de Chile, Santiago, Chile.; Center for Regenerative Medicine, Faculty of Medicine, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile., Kretschmar C; Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile., Contreras P; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences and Faculty of Medicine, Universidad de Chile, Santiago, Chile.; Laboratory of Cellular Communication, Center for studies on Exercise, Metabolism and Cancer (CEMC), Faculty of Medicine, Universidad de Chile, Santiago, Chile., Maturana-Ramírez A; Department of Pathology and Oral Medicine, Faculty of Dentistry, Universidad de Chile, Santiago, Chile., Criollo A; Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences and Faculty of Medicine, Universidad de Chile, Santiago, Chile., Reyes M; Department of Pathology and Oral Medicine, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Jan 05; Vol. 30 (1), pp. 209-223.

Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism.

Autor: Ávalos Y; Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile., Hernández-Cáceres MP; Laboratory of Autophagy and Metabolism, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.; Cellular and Molecular Biology Laboratory, Institute in Dentistry Sciences, Dentistry Faculty, Universidad de Chile, Santiago, Chile., Lagos P; Laboratory of Autophagy and Metabolism, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Pinto-Nuñez D; Laboratory of Autophagy and Metabolism, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Rivera P; Laboratory of Autophagy and Metabolism, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Burgos P; Laboratory of Autophagy and Metabolism, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Díaz-Castro F; Laboratory of Autophagy and Metabolism, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Joy-Immediato M; Laboratory for Molecular Mechanics of Cell Adhesion, Pontificia Universidad Católica de Chile, Santiago, Chile., Venegas-Zamora L; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences and Faculty of Medicine, Universidad de Chile, Santiago, Chile., Lopez-Gallardo E; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences and Faculty of Medicine, Universidad de Chile, Santiago, Chile., Kretschmar C; Cellular and Molecular Biology Laboratory, Institute in Dentistry Sciences, Dentistry Faculty, Universidad de Chile, Santiago, Chile., Batista-Gonzalez A; Cellular and Molecular Biology Laboratory, Institute in Dentistry Sciences, Dentistry Faculty, Universidad de Chile, Santiago, Chile., Cifuentes-Araneda F; Laboratory of Autophagy and Metabolism, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Toledo-Valenzuela L; Laboratory of Autophagy and Metabolism, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Rodriguez-Peña M; Cellular and Molecular Biology Laboratory, Institute in Dentistry Sciences, Dentistry Faculty, Universidad de Chile, Santiago, Chile., Espinoza-Caicedo J; Laboratory of Autophagy and Metabolism, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Perez-Leighton C; Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Bertocchi C; Laboratory for Molecular Mechanics of Cell Adhesion, Pontificia Universidad Católica de Chile, Santiago, Chile., Cerda M; Integrative Biology Program, Institute of Biomedical Sciences, Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Center for Medical Informatics and Telemedicine, Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Biomedical Neuroscience Institute, Santiago, Chile., Troncoso R; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences and Faculty of Medicine, Universidad de Chile, Santiago, Chile.; Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, Chile.; Autophagy Research Center, Santiago, Chile., Parra V; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences and Faculty of Medicine, Universidad de Chile, Santiago, Chile.; Autophagy Research Center, Santiago, Chile.; Network for the Study of High-Lethality Cardiopulmonary Diseases (REECPAL), Universidad de Chile, Santiago, Chile., Budini M; Autophagy Research Center, Santiago, Chile.; Laboratory of Molecular and Cellular Pathology, Institute in Dentistry Sciences, Dentistry Faculty, Universidad de Chile, Santiago, Chile., Burgos PV; Autophagy Research Center, Santiago, Chile.; Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile.; Centro de Envejecimiento y Regeneración (CARE-UC), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile., Criollo A; Cellular and Molecular Biology Laboratory, Institute in Dentistry Sciences, Dentistry Faculty, Universidad de Chile, Santiago, Chile. alcriollo@u.uchile.cl.; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences and Faculty of Medicine, Universidad de Chile, Santiago, Chile. alcriollo@u.uchile.cl.; Autophagy Research Center, Santiago, Chile. alcriollo@u.uchile.cl., Morselli E; Laboratory of Autophagy and Metabolism, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile. eugenia.morselli@uss.cl.; Autophagy Research Center, Santiago, Chile. eugenia.morselli@uss.cl.; Department of Basic Sciences, Faculty of Medicine and Sciences, Universidad San Sebastián, Santiago, Chile. eugenia.morselli@uss.cl.

Publikováno v: Cell death & disease [Cell Death Dis] 2022 Jul 28; Vol. 13 (7), pp. 659. Date of Electronic Publication: 2022 Jul 28.

Distinct Immunophenotypes in the DNA Index-Based Stratification of Pediatric B-Cell Acute Lymphoblastic Leukemia.

Autor: Campos-Aguilar, Myriam¹ (AUTHOR), Tapia-Sánchez, Wilfrido David² (AUTHOR), Saucedo-Campos, Alberto Daniel¹ (AUTHOR), Duarte-Martínez, Carlos Leonardo² (AUTHOR), Olivas-Quintero, Sandra³ (AUTHOR) sandra.olivas@uadeo.mx, Ruiz-Ochoa, Almarosa² (AUTHOR), Méndez-Cruz, Adolfo Rene² (AUTHOR), Reyes-Reali, Julia² (AUTHOR), Mendoza-Ramos, María Isabel² (AUTHOR), Jimenez-Flores, Rafael² (AUTHOR), Pozo-Molina, Glustein⁴ (AUTHOR), Piedra-Ibarra, Elias⁵ (AUTHOR), Vega Hernandez, Maria Eugenia⁶ (AUTHOR), Santos-Argumedo, Leopoldo^7,8 (AUTHOR), Rosales-García, Victor Hugo^2,9 (AUTHOR), Ponciano-Gómez, Alberto¹ (AUTHOR) alberto_ponciano@comunidad.unam.mx

Publikováno v: Cancers. Nov2024, Vol. 16 Issue 21, p3585. 15p.

Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma.

Autor: Peña-Oyarzún D; Advanced Center for Chronic Disease (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas and Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Facultad de Odontología, Instituto de Investigación en Ciencias Odontológicas, Universidad de Chile, Santiago, Chile.; Autophagy Research Center, Universidad de Chile, Santiago, Chile.; Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile., Reyes M; Departamento de Patología y Medicina Oral, Facultad de Odontología, Universidad de Chile, Santiago, Chile., Hernández-Cáceres MP; Autophagy Research Center, Universidad de Chile, Santiago, Chile.; Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile., Kretschmar C; Advanced Center for Chronic Disease (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas and Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Facultad de Odontología, Instituto de Investigación en Ciencias Odontológicas, Universidad de Chile, Santiago, Chile.; Autophagy Research Center, Universidad de Chile, Santiago, Chile., Morselli E; Autophagy Research Center, Universidad de Chile, Santiago, Chile.; Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile., Ramirez-Sarmiento CA; Facultades de Ingenieria, Medicina y Ciencias Biológicas, Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile., Lavandero S; Advanced Center for Chronic Disease (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas and Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States., Torres VA; Advanced Center for Chronic Disease (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas and Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Facultad de Odontología, Instituto de Investigación en Ciencias Odontológicas, Universidad de Chile, Santiago, Chile., Criollo A; Advanced Center for Chronic Disease (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas and Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Facultad de Odontología, Instituto de Investigación en Ciencias Odontológicas, Universidad de Chile, Santiago, Chile.; Autophagy Research Center, Universidad de Chile, Santiago, Chile.

Publikováno v: Frontiers in oncology [Front Oncol] 2020 Dec 09; Vol. 10, pp. 602661. Date of Electronic Publication: 2020 Dec 09 (Print Publication: 2020).