Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Krestian Larsen"'
Autor:
Connie Sanchez, Krestian Larsen, Peter Bregnedal, Benny Bang-Andersen, Sid Topiol, Klaus Peter Bogeso, Claus J. Loland, Per Plenge, Karsten Juhl
Publikováno v:
Topiol, S, Bang-Andersen, B, Sanchez, C, Plenge, P, Loland, C J, Juhl, K, Larsen, K, Bregnedal, P & Bogeso, K P 2017, ' X-ray structure based evaluation of analogs of citalopram : Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT ', Bioorganic & Medicinal Chemistry Letters, vol. 27, no. 3, pp. 470-478 . https://doi.org/10.1016/j.bmcl.2016.12.037
The recent publication of X-ray structures of SERT includes structures with the potent antidepressant S-Citalopram (S-Cit). Earlier predictions of ligand binding at both a primary (S1) and an allosteric modulator site (S2), were confirmed. We provide
Autor:
Gitte Mikkelsen, Klaus Gjervig Jensen, Morten Hentzer, Benny Bang-Andersen, Krestian Larsen, Claus Tornby Christoffersen, Kristen Frederiksen, Anette Graven Sams
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(15)
We describe the discovery of a series of compounds based on 1-{3-[4-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin-1-yl]-propyl}-3,4-dihydro-1H-quinolin-2-one (3), showing combined D2 receptor affinity and M1 receptor agonism. Based on a strategy o
Autor:
Christoffer Bundgaard, Niels Plath, Krestian Larsen, Anette Graven Sams, Benny Bang-Andersen, Gitte Mikkelsen, Morten Hentzer, Claus Tornby Christoffersen
Publikováno v:
Journal of medicinal chemistry. 53(17)
The discovery and structure-activity relationship (SAR) of a series of allosteric muscarinic M(1) receptor agonists are described. Compound 17 (Lu AE51090) was identified as a representative compound from the series, based on its high selectivity as