Computational modelling of clot development in patient-specific cerebral aneurysm cases: comment.

Autor: Kremers RM; Synapse Research Institute, CARIM, Maastricht University, Maastricht, the Netherlands.; Department of Biochemistry, CARIM, Maastricht University, Maastricht, the Netherlands., de Laat B; Synapse Research Institute, CARIM, Maastricht University, Maastricht, the Netherlands.; Department of Biochemistry, CARIM, Maastricht University, Maastricht, the Netherlands., Wagenvoord RJ; Synapse Research Institute, CARIM, Maastricht University, Maastricht, the Netherlands.; Department of Biochemistry, CARIM, Maastricht University, Maastricht, the Netherlands., Hemker HC; Synapse Research Institute, CARIM, Maastricht University, Maastricht, the Netherlands.; Department of Biochemistry, CARIM, Maastricht University, Maastricht, the Netherlands.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2017 Feb; Vol. 15 (2), pp. 395-396. Date of Electronic Publication: 2017 Feb 03.

A reduction of prothrombin conversion by cardiac surgery with cardiopulmonary bypass shifts the haemostatic balance towards bleeding.

Autor: Kremers RM; Romy Kremers, Oxfordlaan 70, 6229 EV, Maastricht, the Netherlands, Tel.: +31 43 388 5891, Fax: +31 43 388 4570, E-mail: r.kremers@thrombin.com., Bosch YP, Bloemen S, de Laat B, Weerwind PW, Mochtar B, Maessen JG, Wagenvoord RJ, Al Dieri R, Hemker HC

Publikováno v: Thrombosis and haemostasis [Thromb Haemost] 2016 Aug 30; Vol. 116 (3), pp. 442-51. Date of Electronic Publication: 2016 Apr 28.

Strenuous exercise induces a hyperreactive rebalanced haemostatic state that is more pronounced in men.

Autor: Huskens D; Dana Huskens, Oxfordlaan 70, Maastricht 6229EV, The Netherlands, Tel.: +31 43 388 58 96, Fax: +31 43 388 45 70, E-mail: D.Huskens@thrombin.com., Roest M, Remijn JA, Konings J, Kremers RM, Bloemen S, Schurgers E, Selmeczi A, Kelchtermans H, van Meel R, Meex SJ, Kleinegris MC, de Groot PG, Urbanus RT, Ninivaggi M, de Laat B

Publikováno v: Thrombosis and haemostasis [Thromb Haemost] 2016 Jun 02; Vol. 115 (6), pp. 1109-19. Date of Electronic Publication: 2016 Feb 11.

Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity.

Autor: Mastenbroek TG; From the Department of Biochemistry (T.G.M., M.A.H.F., R.M.W.K., M.T.J.v.d.B., F.S., P.E.J.v.d.M., J.M.E.M.C.) and Synapse BV (R.M.W.K.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; School of Physiology and Pharmacology (M.T.J.v.d.B.) and School of Clinical Sciences (J.L.J.), University of Bristol, Bristol, United Kingdom; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (L.D.G., L.M.); Department of Haematology, University of Cambridge, Cambridge, United Kingdom (C.B., C.G.); and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom (C.B., C.G.)., Feijge MA; From the Department of Biochemistry (T.G.M., M.A.H.F., R.M.W.K., M.T.J.v.d.B., F.S., P.E.J.v.d.M., J.M.E.M.C.) and Synapse BV (R.M.W.K.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; School of Physiology and Pharmacology (M.T.J.v.d.B.) and School of Clinical Sciences (J.L.J.), University of Bristol, Bristol, United Kingdom; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (L.D.G., L.M.); Department of Haematology, University of Cambridge, Cambridge, United Kingdom (C.B., C.G.); and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom (C.B., C.G.)., Kremers RM; From the Department of Biochemistry (T.G.M., M.A.H.F., R.M.W.K., M.T.J.v.d.B., F.S., P.E.J.v.d.M., J.M.E.M.C.) and Synapse BV (R.M.W.K.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; School of Physiology and Pharmacology (M.T.J.v.d.B.) and School of Clinical Sciences (J.L.J.), University of Bristol, Bristol, United Kingdom; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (L.D.G., L.M.); Department of Haematology, University of Cambridge, Cambridge, United Kingdom (C.B., C.G.); and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom (C.B., C.G.)., van den Bosch MT; From the Department of Biochemistry (T.G.M., M.A.H.F., R.M.W.K., M.T.J.v.d.B., F.S., P.E.J.v.d.M., J.M.E.M.C.) and Synapse BV (R.M.W.K.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; School of Physiology and Pharmacology (M.T.J.v.d.B.) and School of Clinical Sciences (J.L.J.), University of Bristol, Bristol, United Kingdom; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (L.D.G., L.M.); Department of Haematology, University of Cambridge, Cambridge, United Kingdom (C.B., C.G.); and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom (C.B., C.G.)., Swieringa F; From the Department of Biochemistry (T.G.M., M.A.H.F., R.M.W.K., M.T.J.v.d.B., F.S., P.E.J.v.d.M., J.M.E.M.C.) and Synapse BV (R.M.W.K.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; School of Physiology and Pharmacology (M.T.J.v.d.B.) and School of Clinical Sciences (J.L.J.), University of Bristol, Bristol, United Kingdom; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (L.D.G., L.M.); Department of Haematology, University of Cambridge, Cambridge, United Kingdom (C.B., C.G.); and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom (C.B., C.G.)., De Groef L; From the Department of Biochemistry (T.G.M., M.A.H.F., R.M.W.K., M.T.J.v.d.B., F.S., P.E.J.v.d.M., J.M.E.M.C.) and Synapse BV (R.M.W.K.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; School of Physiology and Pharmacology (M.T.J.v.d.B.) and School of Clinical Sciences (J.L.J.), University of Bristol, Bristol, United Kingdom; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (L.D.G., L.M.); Department of Haematology, University of Cambridge, Cambridge, United Kingdom (C.B., C.G.); and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom (C.B., C.G.)., Moons L; From the Department of Biochemistry (T.G.M., M.A.H.F., R.M.W.K., M.T.J.v.d.B., F.S., P.E.J.v.d.M., J.M.E.M.C.) and Synapse BV (R.M.W.K.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; School of Physiology and Pharmacology (M.T.J.v.d.B.) and School of Clinical Sciences (J.L.J.), University of Bristol, Bristol, United Kingdom; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (L.D.G., L.M.); Department of Haematology, University of Cambridge, Cambridge, United Kingdom (C.B., C.G.); and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom (C.B., C.G.)., Bennett C; From the Department of Biochemistry (T.G.M., M.A.H.F., R.M.W.K., M.T.J.v.d.B., F.S., P.E.J.v.d.M., J.M.E.M.C.) and Synapse BV (R.M.W.K.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; School of Physiology and Pharmacology (M.T.J.v.d.B.) and School of Clinical Sciences (J.L.J.), University of Bristol, Bristol, United Kingdom; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (L.D.G., L.M.); Department of Haematology, University of Cambridge, Cambridge, United Kingdom (C.B., C.G.); and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom (C.B., C.G.)., Ghevaert C; From the Department of Biochemistry (T.G.M., M.A.H.F., R.M.W.K., M.T.J.v.d.B., F.S., P.E.J.v.d.M., J.M.E.M.C.) and Synapse BV (R.M.W.K.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; School of Physiology and Pharmacology (M.T.J.v.d.B.) and School of Clinical Sciences (J.L.J.), University of Bristol, Bristol, United Kingdom; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (L.D.G., L.M.); Department of Haematology, University of Cambridge, Cambridge, United Kingdom (C.B., C.G.); and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom (C.B., C.G.)., Johnson JL; From the Department of Biochemistry (T.G.M., M.A.H.F., R.M.W.K., M.T.J.v.d.B., F.S., P.E.J.v.d.M., J.M.E.M.C.) and Synapse BV (R.M.W.K.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; School of Physiology and Pharmacology (M.T.J.v.d.B.) and School of Clinical Sciences (J.L.J.), University of Bristol, Bristol, United Kingdom; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (L.D.G., L.M.); Department of Haematology, University of Cambridge, Cambridge, United Kingdom (C.B., C.G.); and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom (C.B., C.G.)., van der Meijden PE; From the Department of Biochemistry (T.G.M., M.A.H.F., R.M.W.K., M.T.J.v.d.B., F.S., P.E.J.v.d.M., J.M.E.M.C.) and Synapse BV (R.M.W.K.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; School of Physiology and Pharmacology (M.T.J.v.d.B.) and School of Clinical Sciences (J.L.J.), University of Bristol, Bristol, United Kingdom; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (L.D.G., L.M.); Department of Haematology, University of Cambridge, Cambridge, United Kingdom (C.B., C.G.); and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom (C.B., C.G.)., Cosemans JM; From the Department of Biochemistry (T.G.M., M.A.H.F., R.M.W.K., M.T.J.v.d.B., F.S., P.E.J.v.d.M., J.M.E.M.C.) and Synapse BV (R.M.W.K.), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; School of Physiology and Pharmacology (M.T.J.v.d.B.) and School of Clinical Sciences (J.L.J.), University of Bristol, Bristol, United Kingdom; Neural Circuit Development and Regeneration Research Group, Department of Biology, KU Leuven, Leuven, Belgium (L.D.G., L.M.); Department of Haematology, University of Cambridge, Cambridge, United Kingdom (C.B., C.G.); and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom (C.B., C.G.). judith.cosemans@maastrichtuniversity.nl.

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2015 Dec; Vol. 35 (12), pp. 2554-61. Date of Electronic Publication: 2015 Oct 15.

Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome).

Autor: van der Meijden PE; Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), Department of Biochemistry, Maastricht, The Netherlands. Electronic address: http://www.labcth.org., Ozaki Y; University of Yamanashi, Department of Clinical and Laboratory Medicine, Yamanashi, Japan., Ruf W; The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, CA, USA; University Medical Center Mainz, Center for Thrombosis and Hemostasis, Mainz, Germany., de Laat B; Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), Department of Biochemistry, Maastricht, The Netherlands; Synapse BV and Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands., Mutch N; University of Aberdeen, Institute of Medical Sciences, Aberdeen, UK., Diamond S; University of Pennsylvania, Institute for Medicine and Engineering, Philadelphia, PA, USA., Nieuwland R; Academic Medical Centre of the University of Amsterdam, Department of Clinical Chemistry, Amsterdam, The Netherlands., Peters TC; Synapse BV and Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands., Heestermans M; Leiden University Medical Centre, Department of Thrombosis and Hemostasis, Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., Kremers RM; Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), Department of Biochemistry, Maastricht, The Netherlands; Synapse BV and Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands., Moorlag M; Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), Department of Biochemistry, Maastricht, The Netherlands; Synapse BV and Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands., Boender J; Erasmus University Medical Center, Department of Hematology, Rotterdam, The Netherlands., Ünlü B; Leiden University Medical Centre, Department of Thrombosis and Hemostasis, Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., Reitsma PH; Leiden University Medical Centre, Department of Thrombosis and Hemostasis, Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands.

Publikováno v: Thrombosis research [Thromb Res] 2015 Sep; Vol. 136 Suppl 1, pp. S3-7.