Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients.

Autor: Chen C; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, China., Bartenhagen C; Institute of Medical Informatics, University of Münster, Münster, Germany., Gombert M; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Okpanyi V; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Binder V; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Röttgers S; Oncogenetic Laboratory, Department of Pediatric Hematology and Oncology, Justus Liebig University, Giessen, Germany., Bradtke J; Oncogenetic Laboratory, Department of Pediatric Hematology and Oncology, Justus Liebig University, Giessen, Germany., Teigler-Schlegel A; Oncogenetic Laboratory, Department of Pediatric Hematology and Oncology, Justus Liebig University, Giessen, Germany., Harbott J; Oncogenetic Laboratory, Department of Pediatric Hematology and Oncology, Justus Liebig University, Giessen, Germany., Ginzel S; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Department of Computer Science, Bonn-Rhine-Sieg University of Applied Sciences, Sankt Augustin, Germany., Thiele R; Department of Computer Science, Bonn-Rhine-Sieg University of Applied Sciences, Sankt Augustin, Germany., Husemann P; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Krell PF; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Borkhardt A; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Dugas M; Institute of Medical Informatics, University of Münster, Münster, Germany., Hu J; Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, China. Electronic address: jdhu@medmail.com.cn., Fischer U; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. Electronic address: ute.fischer@med.uni-duesseldorf.de.

Publikováno v: Leukemia research [Leuk Res] 2015 Sep; Vol. 39 (9), pp. 990-1001. Date of Electronic Publication: 2015 Jun 14.

Genomic inverse PCR for exploration of ligated breakpoints (GIPFEL), a new method to detect translocations in leukemia.

Autor: Fueller E; Department of Genetics, Friedrich Alexander University, Erlangen, Germany., Schaefer D; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Fischer U; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Krell PF; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Stanulla M; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany., Borkhardt A; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Slany RK; Department of Genetics, Friedrich Alexander University, Erlangen, Germany.

Publikováno v: PloS one [PLoS One] 2014 Aug 19; Vol. 9 (8), pp. e104419. Date of Electronic Publication: 2014 Aug 19 (Print Publication: 2014).