FTY720 enhances the anti-tumor activity of carboplatin and tamoxifen in a patient-derived xenograft model of ovarian cancer.

Autor: Kreitzburg KM; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA., Fehling SC; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA., Landen CN; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Virginia School of Medicine, Charlottesville, VA, USA., Gamblin TL; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA., Vance RB; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA., Arend RC; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA., Katre AA; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA., Oliver PG; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA., van Waardenburg RCAM; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA., Alvarez RD; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA., Yoon KJ; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: kyoon@uab.edu.

Publikováno v: Cancer letters [Cancer Lett] 2018 Nov 01; Vol. 436, pp. 75-86. Date of Electronic Publication: 2018 Aug 16.

The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models.

Autor: Garcia PL; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA., Miller AL; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA., Kreitzburg KM; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA., Council LN; Division of Anatomic Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Gamblin TL; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA., Christein JD; Division of General Surgery, Gastrointestinal Surgery or Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Heslin MJ; Division of General Surgery, Gastrointestinal Surgery or Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Arnoletti JP; Division of General Surgery, Gastrointestinal Surgery or Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Richardson JH; Division of General Surgery, Gastrointestinal Surgery or Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Chen D; Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Hanna CA; Division of Anatomic Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Cramer SL; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA., Yang ES; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA., Qi J; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA., Bradner JE; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA., Yoon KJ; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA.

Publikováno v: Oncogene [Oncogene] 2016 Feb 18; Vol. 35 (7), pp. 833-45. Date of Electronic Publication: 2015 May 11.

Gα(12) binds to the N-terminal regulatory domain of p120(ctn), and downregulates p120(ctn) tyrosine phosphorylation induced by Src family kinases via a RhoA independent mechanism.

Autor: Ardawatia VV; Department of Biomedicine, University of Bergen, Bergen, Norway., Masià-Balagué M, Krakstad BF, Johansson BB, Kreitzburg KM, Spriet E, Lewis AE, Meigs TE, Aragay AM

Publikováno v: Experimental cell research [Exp Cell Res] 2011 Feb 01; Vol. 317 (3), pp. 293-306. Date of Electronic Publication: 2010 Oct 23.