Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Krešimir, Josić"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Two facts about cortex are widely accepted: neuronal responses show large spiking variability with near Poisson statistics and cortical circuits feature abundant recurrent connections between neurons. How these spiking and circuit properties
Externí odkaz:
https://doaj.org/article/13e21d60ccc6476dbc8dbab75984a75b
Publikováno v:
Physical Review Research, Vol 5, Iss 3, p 033020 (2023)
Normative models are often used to describe how humans and animals make decisions. These models treat deliberation as the accumulation of uncertain evidence that terminates with a commitment to a choice. When extended to social groups, such models of
Externí odkaz:
https://doaj.org/article/aa12e4b12e284b16941d986a3e8a4c77
Publikováno v:
eLife, Vol 11 (2022)
Models based on normative principles have played a major role in our understanding of how the brain forms decisions. However, these models have typically been derived for simple, stable conditions, and their relevance to decisions formed under more n
Externí odkaz:
https://doaj.org/article/61b09d595f134089bbadc8b426dd1d18
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 7, p e1010323 (2022)
Solutions to challenging inference problems are often subject to a fundamental trade-off between: 1) bias (being systematically wrong) that is minimized with complex inference strategies, and 2) variance (being oversensitive to uncertain observations
Externí odkaz:
https://doaj.org/article/ce1c1a6ddce44603a87fd2c6a144943f
Publikováno v:
eLife, Vol 11 (2022)
Deliberative decisions based on an accumulation of evidence over time depend on working memory, and working memory has limitations, but how these limitations affect deliberative decision-making is not understood. We used human psychophysics to assess
Externí odkaz:
https://doaj.org/article/cdec7f3cf48f4475a4a549bf9efa00d7
Autor:
Razan N. Alnahhas, Mehdi Sadeghpour, Ye Chen, Alexis A. Frey, William Ott, Krešimir Josić, Matthew R. Bennett
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Designing distributed circuits that respond predictably to variation in bacterial populations remains difficult. Here the authors develop a two-strain circuit that senses and responds to the majority strain.
Externí odkaz:
https://doaj.org/article/386c8c353d4244eaa9742268057f58c4
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009381 (2021)
The increased complexity of synthetic microbial biocircuits highlights the need for distributed cell functionality due to concomitant increases in metabolic and regulatory burdens imposed on single-strain topologies. Distributed systems, however, int
Externí odkaz:
https://doaj.org/article/b5d3e5a515724a449fca718d2c8ac1d0
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008958 (2021)
The dynamics of local cortical networks are irregular, but correlated. Dynamic excitatory-inhibitory balance is a plausible mechanism that generates such irregular activity, but it remains unclear how balance is achieved and maintained in plastic neu
Externí odkaz:
https://doaj.org/article/1dc96c7a5459470abd950b54fd4bc570
Autor:
Sorena Sarmadi, James J. Winkle, Razan N. Alnahhas, Matthew R. Bennett, Krešimir Josić, Andreas Mang, Robert Azencott
Publikováno v:
Mathematical and Computational Applications, Vol 27, Iss 2, p 22 (2022)
Our work targets automated analysis to quantify the growth dynamics of a population of bacilliform bacteria. We propose an innovative approach to frame-sequence tracking of deformable-cell motion by the automated minimization of a new, specific cost
Externí odkaz:
https://doaj.org/article/f88405103cee470a9911e94d3622a6bc
Autor:
Ye Chen, Joanne M. L. Ho, David L. Shis, Chinmaya Gupta, James Long, Daniel S. Wagner, William Ott, Krešimir Josić, Matthew R. Bennett
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
For synthetic gene circuits to behave as designed, ligand-inducible promoters should display predictable ON/OFF characteristics. Here the authors design multi-input hybrid promoters to build transcriptional logic gates.
Externí odkaz:
https://doaj.org/article/9f191ec1c7d248d3bde26396083e9a7b